{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LIMA1, also known as EPLIN, is a cytoskeleton‐associated actin‐binding protein that plays multiple roles in the regulation of cell adhesion and motility. It couples the cadherin–catenin complex to F‑actin to stabilize adherens junctions—thereby reinforcing epithelial and endothelial cell–cell contacts and maintaining tissue integrity (<!-- -->."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In epithelial cells, this linkage helps to form and maintain the adhesion belt, and in endothelial cells it is critical for proper barrier function. Furthermore, LIMA1 acts as a negative regulator of epithelial‐to‐mesenchymal transition and tumor cell invasiveness; loss or downregulation of LIMA1 is associated with junction disassembly, actin cytoskeleton reorganization, and enhanced migration that contribute to cancer progression and metastasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "5"}]}, {"type": "t", "text": " In addition, signaling events modulate LIMA1 function: for example, ERK‐mediated phosphorylation decreases its affinity for actin filaments, thereby facilitating cytoskeletal reorganization and cell motility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Proteolytic cleavage of LIMA1 by oncogenic fusion proteins, such as API2‑MALT1, can generate LIM domain–only fragments that unexpectedly acquire oncogenic properties and contribute to lymphomagenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, LIMA1 participates in cytokinesis by ensuring proper localization of active myosin and septin proteins at the cleavage furrow"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and it modulates endothelial cell behavior by impacting cell–matrix adhesion and capillary tube formation, thereby influencing angiogenic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight LIMA1 as a multifaceted regulator of actin dynamics and cell adhesion whose proper function is essential for maintaining tissue architecture and suppressing cell invasiveness. Alterations in LIMA1 expression or function contribute to cytoskeletal deregulation, enhanced motility, and metastatic progression in several human cancers.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kentaro Abe, Masatoshi Takeichi "}, {"type": "b", "children": [{"type": "t", "text": "EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0710504105"}], "href": "https://doi.org/10.1073/pnas.0710504105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18093941"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18093941"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Adeline Chervin-Pétinot, Marie Courçon, Sébastien Almagro, et al. 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