{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have implicated the long non‐coding RNA LINC00094 in a variety of pathophysiological processes, suggesting that its function is highly context dependent. In smoking‐related lung squamous cell carcinoma, LINC00094 is downregulated in tumor tissues, and its dysregulation is associated with poor prognosis; this finding indicates that LINC00094 may serve as both a biomarker and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In maternal blood analyses related to spontaneous preterm birth, lower levels of LINC00094 were observed in cases compared to term births. The correlation with EBF1 mRNA and the increased odds of preterm delivery in individuals with the lowest tertile of LINC00094 expression suggest that this lncRNA might play a role in reproductive regulation and could provide a predictive biomarker for risk assessment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In esophageal squamous cell carcinoma, LINC00094 was identified as a super-enhancer–associated competing endogenous RNA (ceRNA). It is activated by transcription factors TCF3 and KLF5 and promotes cancer cell growth, with its expression being downregulated by the CDK7 inhibitor THZ1. This highlights its oncogenic potential in this tumor type."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in the context of Alzheimer’s disease, LINC00094 was found to be dramatically increased under beta-amyloid conditions, suggesting a possible role in regulating blood-brain barrier permeability within the AD microenvironment. This finding may contribute to our understanding of the molecular mechanisms underlying AD-related vascular dysfunction."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these data indicate that LINC00094 may function as a context-specific regulatory molecule. Its altered expression in lung and esophageal cancers, in association with adverse clinical outcomes, as well as its involvement in spontaneous preterm birth and Alzheimer’s disease, underscores its potential as a biomarker and as a candidate for targeted intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shicheng Li, Xiao Sun, Shuncheng Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential protein-coding gene and long noncoding RNA expression in smoking-related lung squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12510"}], "href": "https://doi.org/10.1111/1759-7714.12510"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28949095"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28949095"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Guoli Zhou, Claudia Holzman, Bin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EBF1-Correlated Long Non-coding RNA Transcript Levels in 3rd Trimester Maternal Blood and Risk of Spontaneous Preterm Birth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-020-00320-5"}], "href": "https://doi.org/10.1007/s43032-020-00320-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32959224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32959224"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qiu-Yu Wang, Liu Peng, Yang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of super-enhancer-associated functional lncRNAs acting as ceRNAs in ESCC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12726"}], "href": "https://doi.org/10.1002/1878-0261.12726"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32460441"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32460441"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lu Zhu, Meiqing Lin, Jun Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of LINC00094/miR-224-5p (miR-497-5p)/Endophilin-1 axis in Memantine mediated protective effects on blood-brain barrier in AD microenvironment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.14214"}], "href": "https://doi.org/10.1111/jcmm.14214"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30801976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30801976"}]}]}]}