{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Although none of the four abstracts directly address LINC00371, the collective findings from these studies underscore the diverse roles that long non‐coding RNAs (lncRNAs) can play in regulating key biological processes such as fertility, embryonic development, and post‐surgical outcomes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In one study of Nordic Red cattle (1), structural variants—including large deletions that eliminate protein‐coding genes like RNASEH2B—were shown to have profound effects on embryonic viability and fertility despite conferring favorable traits (increased milk yield). This work highlights how genetic alterations can simultaneously exert detrimental effects on reproduction while being maintained in the population due to balancing selection. In parallel, research on the human cumulus–oocyte complex (2) identified several lncRNAs that are highly abundant in MII oocytes and cumulus cells. The inferred functions of these lncRNAs include roles in chromatin remodeling, cell pluripotency, and early embryonic development, which are critical for oocyte quality and developmental competence. Furthermore, a genome‐wide association study in cardiac surgery patients (3) demonstrated that genetic variants in various loci can correlate with postoperative complications, emphasizing the multifactorial nature of genetic influences on health outcomes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although LINC00371 was not specifically mentioned in any of these abstracts, the broader context provided by these studies suggests that, like other lncRNAs, LINC00371 may be involved in modulating gene regulatory networks that impact reproductive success and developmental processes. Continued research and functional analyses will be vital to determine whether LINC00371 contributes similarly to the regulation of embryonic development or related physiological pathways.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, while direct evidence for the function of LINC00371 remains to be elucidated, these studies collectively demonstrate that both coding genes and lncRNAs are important in maintaining a balance between beneficial and detrimental phenotypic traits in diverse biological contexts (1,2,3,4).\n "}]}, {"type": "t", "text": "\n <ul>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "</li>\n <li>"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "</li>\n </ul>"}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naveen Kumar Kadri, Goutam Sahana, Carole Charlier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common occurrence of balancing selection in livestock."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1004049"}], "href": "https://doi.org/10.1371/journal.pgen.1004049"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24391517"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24391517"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Julien Bouckenheimer, Patricia Fauque, Charles-Henri Lecellier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential long non-coding RNA expression profiles in human oocytes and cumulus cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-20727-0"}], "href": "https://doi.org/10.1038/s41598-018-20727-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29396444"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29396444"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sabine Westphal, Christian Stoppe, Matthias Gruenewald, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - a sub-analysis of the RIPHeart-Study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cardiovasc Disord (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12872-019-1002-x"}], "href": "https://doi.org/10.1186/s12872-019-1002-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30678657"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30678657"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rashmi Kanagal-Shamanna, Haiyan Bao, Hutton Kearney, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of Novel "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ATM"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " fusions in chronic lymphocytic leukemia and T-cell prolymphocytic leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leuk Lymphoma (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/10428194.2021.2010061"}], "href": "https://doi.org/10.1080/10428194.2021.2010061"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34898335"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34898335"}]}]}]}