{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00431 is a long noncoding RNA that appears to play a regulatory role in the modulation of inflammatory responses. Evidence indicates that LINC00431 may influence the expression and function of members of the TREM receptor family—particularly TREML4—which are critical mediators of innate immune responses. By affecting TREML4 expression in myeloid cells, LINC00431 is suggested to contribute to the fine‐tuning of inflammatory signaling pathways, potentially impacting both the initiation and resolution of immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the mechanistic details remain to be fully elucidated, current findings support the view that LINC00431 acts as an upstream modulator, possibly interacting with epigenetic regulators and transcriptional machinery to govern TREML4 levels and, consequently, the balance between pro‐ and anti‐inflammatory cytokine production.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Marieli Gonzalez-Cotto, Liang Guo, Megan Karwan, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TREML4"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Promotes Inflammatory Programs in Human and Murine Macrophages and Alters Atherosclerosis Lesion Composition in the Apolipoprotein E Deficient Mouse."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2020.00397"}], "href": "https://doi.org/10.3389/fimmu.2020.00397"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32292401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32292401"}]}]}]}