{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00634 appears to act as an oncogenic long noncoding RNA in multiple cancer contexts. In esophageal cancer, LINC00634 is significantly upregulated in tumor tissues compared with non‐tumor tissues, and its high expression is associated with advanced tumor–node–metastasis stage. Functional studies in esophageal cancer cell lines demonstrated that silencing LINC00634 reduces cell viability and promotes apoptosis via a mechanism involving the miR‑342‑3p/Bcl2L1 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In glioblastoma, LINC00634 was identified as one of seven epithelial‐to‐mesenchymal transition (EMT)–related lncRNAs that together form a prognostic signature. Although the precise mechanistic role of LINC00634 in glioblastoma remains to be fully elucidated, its inclusion in this signature suggests that it is associated with EMT and metastasis‐related pathways as well as with altered immune cell infiltration."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, while studies in the psychiatric domain"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "provided broader insights into transcriptomic and epigenetic dysregulation in neuropsychiatric disorders, they did not specifically address the function of LINC00634. Overall, current evidence suggests that LINC00634 may promote tumor progression by enhancing cell survival and facilitating processes related to EMT, making it a potential target for therapeutic intervention in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaohong Zhang, Yinman Feng, Yanli Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC00634 Functions as an Oncogene in Esophageal Squamous Cell Carcinoma Through the miR-342-3p/Bcl2L1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Technol Cancer Res Treat (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1533033820928508"}], "href": "https://doi.org/10.1177/1533033820928508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32583748"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32583748"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "XinJie Yang, Sha Niu, JiaQiang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of an epithelial-mesenchymal transition-related lncRNA prognostic signature for patients with glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-03213-y"}], "href": "https://doi.org/10.1038/s41598-021-03213-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34880375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34880375"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael J Gandal, Pan Zhang, Evi Hadjimichael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aat8127"}], "href": "https://doi.org/10.1126/science.aat8127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30545856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30545856"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Prashanth Rajarajan, Schahram Akbarian "}, {"type": "b", "children": [{"type": "t", "text": "Use of the epigenetic toolboxto contextualize common variants associated with schizophrenia risk."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dialogues Clin Neurosci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31887/DCNS.2019.21.4/sakbarian"}], "href": "https://doi.org/10.31887/DCNS.2019.21.4/sakbarian"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31949408"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31949408"}]}]}]}