{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent transcriptomic and epigenetic studies have highlighted the diverse roles of non‐coding RNAs and gene regulatory mechanisms in health and disease. For instance, investigations into the late first trimester placenta have revealed a complex transcriptome with sex‐specific expression patterns that underpin normal developmental processes (1), and analyses in Alzheimer’s disease and psychiatric disorders have demonstrated that alterations in gene expression and splicing contribute to disease progression (2,3). In the context of gastric cancer risk after Helicobacter pylori eradication, a genome‐wide methylation study identified several candidate markers that reflect overall epigenomic damage. Among these, "}, {"type": "b", "children": [{"type": "t", "text": "LINC00643"}]}, {"type": "t", "text": " was found to be unmethylated in normal gastric mucosa and becomes aberrantly methylated in patients with gastric cancer compared to individuals with gastric atrophy. Its methylation status, which is highly correlated with that of several other markers, indicates that LINC00643 may serve as a novel epigenetic biomarker to stratify cancer risk following H. pylori eradication (4). This finding suggests that LINC00643, through its epigenetic modification, has potential utility in the early detection and risk assessment of gastric cancer independent of factors such as atrophy, gender, or age.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n <small>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", \n (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", \n (3)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", \n (4)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "</small>\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tania L Gonzalez, Tianyanxin Sun, Alexander F Koeppel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sex differences in the late first trimester human placenta transcriptome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Sex Differ (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13293-018-0165-y"}], "href": "https://doi.org/10.1186/s13293-018-0165-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29335024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29335024"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Hongde Liu, Kun Luo, Donghui Luo "}, {"type": "b", "children": [{"type": "t", "text": "Guanosine monophosphate reductase 1 is a potential therapeutic target for Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-21256-6"}], "href": "https://doi.org/10.1038/s41598-018-21256-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29426890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29426890"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael J Gandal, Pan Zhang, Evi Hadjimichael, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.aat8127"}], "href": "https://doi.org/10.1126/science.aat8127"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30545856"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30545856"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Masahiro Maeda, Satoshi Yamashita, Taichi Shimazu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel epigenetic markers for gastric cancer risk stratification in individuals after Helicobacter pylori eradication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastric Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10120-018-0803-4"}], "href": "https://doi.org/10.1007/s10120-018-0803-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29427040"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29427040"}]}]}]}