LINC00674 Gene

Name long intergenic non-protein coding RNA 674
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the emerging role of long noncoding RNAs in cancer biology, including those with gender‐specific expression profiles. In particular, LINC00674 appears to be involved in the regulation of oncogenic processes by modulating gene expression pathways that affect cell proliferation, migration, and survival. Evidence suggests that alteration in its expression is linked to differences in cancer susceptibility between genders. For instance, one study focusing on Y chromosome–linked lncRNAs, including testis‐specific transcripts, points toward a potential contribution of such noncoding RNAs to male‐predominant cancer features."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Even though the precise molecular mechanisms of LINC00674 remain to be fully elucidated, its association with critical cellular pathways supports its candidacy as both a prognostic biomarker and a possible therapeutic target in oncology.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "I-Lu Lai, Ya-Sian Chang, Wen-Ling Chan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Male-Specific Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "TTTY15"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Inhibits Non-Small Cell Lung Cancer Proliferation and Metastasis via TBX4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms20143473"}], "href": "https://doi.org/10.3390/ijms20143473"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31311130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31311130"}]}]}]}
NCBI Gene ID 100499466
API
Download Associations
Predicted Functions View LINC00674's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00674's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00674's ARCHS4 Predicted Functions.

Functional Associations

LINC00674 has 771 functional associations with biological entities spanning 5 categories (organism, disease, phenotype or trait, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 14 datasets.

Click the + buttons to view associations for LINC00674 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00674 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00674 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Diseases disease perturbations changing expression of LINC00674 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00674 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of LINC00674 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00674 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations transcription factor perturbations changing expression of LINC00674 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Viral Infections virus perturbations changing expression of LINC00674 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00674 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GTEx Tissue Sample Gene Expression Profiles tissue samples with high or low expression of LINC00674 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00674 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles cell lines with high or low expression of LINC00674 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00674 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of LINC00674 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.