{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00675 is a long non‐coding RNA whose dysregulation has been implicated in the pathogenesis of multiple cancer types, although its role appears to be highly context‐dependent. In certain cancers such as gastric cancer, colorectal cancer, bladder cancer, esophageal squamous cell carcinoma, and hepatocellular carcinoma, LINC00675 is frequently downregulated and acts as a tumor suppressor. In these settings, reduced expression of LINC00675 is associated with increased cell proliferation, migration, invasion, epithelial–mesenchymal transition, and metastasis through modulation of key signaling pathways including the Wnt/β‐catenin pathway and alterations in cytoskeletal components (e.g., via interaction with vimentin)."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": " In contrast, in malignancies such as pancreatic ductal adenocarcinoma, glioma, and castration‐resistant prostate cancer, LINC00675 is overexpressed and appears to promote oncogenic processes by enhancing tumor cell proliferation, invasion, metastasis, and therapeutic resistance, potentially through modulation of androgen receptor signaling and stabilization of oncogenic mRNAs."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": " Moreover, in oral squamous cell carcinoma and breast cancer, LINC00675 functions as a competing endogenous RNA—sponging oncogenic microRNAs—to bolster the expression of tumor suppressor genes such as RCAN1 and PTEN, thereby inhibiting malignant progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Finally, meta‐analyses and integrative genomic studies further support the prognostic value of LINC00675, with its aberrant expression levels correlating with advanced tumor stage, metastasis, and overall survival in several tumor types."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings indicate that LINC00675 may function either as a tumor suppressor or an oncogene depending on the cellular context, and its expression status could serve as a valuable diagnostic and prognostic biomarker as well as a potential therapeutic target in cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Shuo Zeng, Xia Xie, Yu-Feng Xiao, et al. 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