{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00680 is a long non‐coding RNA that has emerged as an important oncogenic regulator in multiple cancer types. In esophageal squamous cell carcinoma, for instance, LINC00680 is highly expressed and promotes tumor growth, migration, and invasion by functioning as a competing endogenous RNA (ceRNA) that sequesters miR‑423‑5p, thereby enhancing PAK6 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LINC00680 upregulation is associated with poorer prognosis through increased cell stemness and reduced chemosensitivity to 5‑fluorouracil; it exerts these effects by sponging miR‑568, which leads to activation of AKT3 and its downstream signaling molecules."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In lung adenocarcinoma, LINC00680 contributes to cell cycle progression and proliferation by interacting with the transcription factor GATA6—this interaction attenuates GATA6’s suppressive impact on SOX12 transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Large‐scale CRISPR interference screens and prognostic studies in other malignancies, such as soft-tissue sarcoma, have underscored the clinical relevance of lncRNAs including LINC00680 in tumor biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In glioblastoma, LINC00680 is stabilized by RNA-binding proteins (e.g., EIF4A3) and exerts tumor-promoting functions by sponging miR‑320b, which results in upregulation of the transcription factor EGR3, subsequent enhancement of plakophilin 2 expression, and activation of the EGFR pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Similarly, in non-small cell lung cancer, overexpression of LINC00680 leads to increased proliferation and colony formation, and reduced apoptosis, via a mechanism that involves sponging miR‑410‑3p to upregulate HMGB1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Collectively, these findings indicate that LINC00680 modulates tumorigenesis by regulating key signaling pathways and transcriptional networks—primarily through microRNA sponging and protein interaction mechanisms—thus representing a promising prognostic marker and therapeutic target across diverse cancer types (1,2,3,6,7).\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Song-Tao Xue, Bin Zheng, Shi-Qiang Cao, et al. 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