{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a study of neuroblastoma, comprehensive analyses—combining RNA immunoprecipitation-sequencing, RNA-seq, and ChIP-seq—revealed that a subset of long non-coding RNAs are connected with the histone methyltransferase EZH2. Notably, EZH2 was found to be enriched at the promoter region of 138 lncRNAs, among which LINC00694 was identified. This finding suggests that LINC00694 is potentially regulated by EZH2 through epigenetic mechanisms, implicating it in the complex gene expression networks associated with neuroblastoma tumorigenesis. Although the precise functional role of LINC00694 in the context of neuroblastoma remains to be fully elucidated, its association with EZH2 supports the idea that it might contribute to the regulation of oncogenic pathways and, thereby, to disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mujie Ye, Lulu Xie, Jingjing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Determination of long non-coding RNAs associated with EZH2 in neuroblastoma by RIP-seq, RNA-seq and ChIP-seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2020.11862"}], "href": "https://doi.org/10.3892/ol.2020.11862"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32774475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32774475"}]}]}]}