{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>LINC00854 Function Summary</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent studies suggest that the long non‐coding RNA LINC00854 (noting that one report refers to it as LINC008854) may play a role in modulating breast cancer risk by participating in complex gene regulatory networks. In one investigation of North‐African breast cancer genetics, an expression‐associated variant (rs9911630) was found to strongly affect the expression levels of BRCA1 along with two lncRNAs (NBR2 and LINC00854), implying that altered levels of this lncRNA could influence pathways of tumor suppression and cellular homeostasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Moreover, recent advances in epigenome editing—using chemical‐inducible systems to temporally control 5‑methylcytosine oxidation—and chromatin state remodeling have demonstrated that dynamic epigenetic modifications can modulate chromatin accessibility without altering the genetic code."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Complementing these approaches, network‐based analyses of 3D chromatin interactions have begun to uncover how lncRNAs, including evolutionarily conserved ones, often serve as hub elements in regulatory modules that guide transcriptional regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Together, these findings indicate that LINC00854 may function as a component of an epigenetically regulated network, thereby influencing gene expression programs relevant to breast cancer pathogenesis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yosr Hamdi, Mariem Ben Rekaya, Shan Jingxuan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-018-5133-8"}], "href": "https://doi.org/10.1186/s12885-018-5133-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30594178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30594178"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Minjung Lee, Jia Li, Yi Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Engineered Split-TET2 Enzyme for Inducible Epigenetic Remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Am Chem Soc (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/jacs.7b01459"}], "href": "https://doi.org/10.1021/jacs.7b01459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28294608"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28294608"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Denise Thiel, Nataša Djurdjevac Conrad, Evgenia Ntini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-019-2900-8"}], "href": "https://doi.org/10.1186/s12859-019-2900-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31142264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31142264"}]}]}]}