{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic noncoding RNA LINC00890 has emerged as a transcript of interest in studies of musculoskeletal and uterine pathologies. In a genome‐wide association and transcriptomic meta‐analysis addressing rotator cuff disease, a locus encompassing LINC00890 alongside ALG13 was identified as being associated with an increased genetic risk for tendon injury. Although the mechanistic details remain to be fully elucidated, this genetic association suggests that LINC00890 may participate in regulatory pathways that influence tendon structural integrity or repair mechanisms following injury."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In parallel, comprehensive RNA sequencing analyses in leiomyomas have confirmed differential expression of LINC00890 when comparing fibroid tissue with matched myometrium. This observation implicates LINC00890 as a potential regulator within the complex network of noncoding RNAs, microRNAs, and mRNAs that underlie the pathogenesis of uterine fibroids, although its precise functional role requires further investigation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n It should be noted that, while another study on pelvic organ prolapse provided insights into altered gene expression profiles associated with extracellular matrix remodeling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", LINC00890 was not specifically discussed in that context. Nonetheless, the differential expression and genetic association of LINC00890 in both rotator cuff disease and leiomyomas collectively support the concept that this lncRNA may have regulatory functions in tissue-specific disease processes.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stuart K Kim, Condor Nguyen, Kevin B Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study for shoulder impingement and rotator cuff disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Shoulder Elbow Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jse.2020.11.025"}], "href": "https://doi.org/10.1016/j.jse.2020.11.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33482370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33482370"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tsai-Der Chuang, Omid Khorram "}, {"type": "b", "children": [{"type": "t", "text": "Expression Profiling of lncRNAs, miRNAs, and mRNAs and Their Differential Expression in Leiomyoma Using Next-Generation RNA Sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/1933719117711265"}], "href": "https://doi.org/10.1177/1933719117711265"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28587571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28587571"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ruoyun Xie, Ying Xu, Shuixiu Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Differentially Expressed Genes in Pelvic Organ Prolapse by RNA-Seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/msm.900224"}], "href": "https://doi.org/10.12659/msm.900224"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27818488"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27818488"}]}]}]}