{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00959 appears to play multifaceted roles in cancer that vary by tumor type. In lung adenocarcinoma, a single‐nucleotide polymorphism (rs4751162A>G) in LINC00959 was associated with worse disease‐free survival and was linked to increased promoter activity of the downstream gene GLRX3, suggesting that genetic variation in its regulatory region may affect tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, lower expression of LINC00959 was observed compared with normal tissue, and higher levels were correlated with earlier tumor stage, less metastasis, and better prognosis. These findings indicate a potential tumor‐suppressive role for LINC00959 in this setting."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In contrast, studies in breast cancer have shown that elevated levels of LINC00959 are associated with negative clinicopathological features—including correlations with estrogen receptor, progesterone receptor, HER2 statuses, and Ki67—and predict poorer overall as well as relapse‐free survival, suggesting an oncogenic role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, transcriptome profiling in lung squamous cell carcinoma identified LINC00959 as part of a small panel that effectively distinguished tumor tissue from normal and was associated with a higher risk profile, underscoring its potential utility as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, in the context of parathyroid neoplasms, LINC00959 was one of several dysregulated lncRNAs used to calculate a global score that differentiated parathyroid carcinoma from adenoma, supporting its further exploration as a diagnostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although one study focused on a related lipogenesis‐associated lncRNA (LINC00958) in hepatocellular carcinoma—highlighting the importance of lncRNAs in tumor metabolism and progression"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "—the collective findings on LINC00959 suggest that its function is likely context‐dependent, serving as either a tumor suppressor or oncogene, and that its genetic variants and expression levels can serve as valuable biomarkers for prognosis and diagnosis in multiple cancer types.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hyo-Gyoung Kang, Yong Hoon Lee, Shin Yup Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants in histone modification regions are associated with the prognosis of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-00909-z"}], "href": "https://doi.org/10.1038/s41598-021-00909-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34728688"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34728688"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhen-Qiang Sun, Chen Chen, Quan-Bo Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00959 predicts colorectal cancer patient prognosis and inhibits tumor progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.21171"}], "href": "https://doi.org/10.18632/oncotarget.21171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29228592"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29228592"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Weiru Chi, Sheng Huang, Bingqiu Xiu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High expression of Linc00959 predicts poor prognosis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0748-7"}], "href": "https://doi.org/10.1186/s12935-019-0748-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30828265"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30828265"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jieqiong Liu, Yali Yao, Zheyu Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional profiling of long-intergenic noncoding RNAs in lung squamous cell carcinoma and its value in diagnosis and prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Genomic Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mgg3.994"}], "href": "https://doi.org/10.1002/mgg3.994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31617686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31617686"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "T Jiang, B J Wei, D X Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide analysis of differentially expressed lncRNA in sporadic parathyroid tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Osteoporos Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00198-019-04959-y"}], "href": "https://doi.org/10.1007/s00198-019-04959-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30972448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30972448"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xueliang Zuo, Zhiqiang Chen, Wen Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-019-0839-x"}], "href": "https://doi.org/10.1186/s13045-019-0839-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31915027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31915027"}]}]}]}