{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01057 is an oncogenic long non‐coding RNA that is overexpressed in glioblastomas, particularly in the mesenchymal subtype, where its high expression correlates with enhanced proliferation, invasion, radioresistance, and tumor growth in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Mechanistically, LINC01057 interacts with IKKα to maintain its nuclear localization, thereby promoting chromatin accessibility at NF‐κB responsive promoters through histone modifications and ultimately driving NF‐κB activation. This signaling cascade promotes mesenchymal differentiation and facilitates the proneural-to-mesenchymal transition (PMT). In addition, LINC01057 has been identified as one of several PMT‐related lncRNAs within a prognostically significant signature that is associated with aggressive glioma behavior and an immunosuppressive tumor microenvironment characterized by the recruitment of macrophages, neutrophils, and regulatory T cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings underscore the role of LINC01057 in promoting mesenchymal features in gliomas and highlight its potential as a diagnostic marker, prognostic factor, and therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guodong Tang, Liyun Luo, Jianlei Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncRNA LINC01057 promotes mesenchymal differentiation by activating NF-κB signaling in glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2020.10.047"}], "href": "https://doi.org/10.1016/j.canlet.2020.10.047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33130316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33130316"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qingyu Liang, Gefei Guan, Xue Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Profiling pro-neural to mesenchymal transition identifies a lncRNA signature in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-020-02552-0"}], "href": "https://doi.org/10.1186/s12967-020-02552-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33028341"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33028341"}]}]}]}