{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‑coding RNA LINC01125 has emerged as a multifaceted regulator in cancer, demonstrating tumor‐suppressive functions across several malignancies. In non‐small cell lung cancer (NSCLC), a novel isoform of LINC01125 was identified in serum exosomes and shown to serve as a promising diagnostic and prognostic biomarker. Functionally, LINC01125 acts as a competing endogenous RNA, sponging miR‑19b‑3p to upregulate TNFAIP3 expression, which in turn helps to inhibit cancer growth and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In breast cancer, treatment with the liver X receptor agonist LXR‑623 significantly increases LINC01125 expression, thereby enhancing its anti‑proliferative and pro‑apoptotic effects through modulation of the PTEN/AKT/MDM2/p53 signaling pathway. In addition, gene expression analyses have identified LINC01125 as part of a protective 6‑gene signature associated with a lower risk of metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In ovarian cancer, LINC01125 expression is significantly downregulated in cisplatin‑resistant tissues and cell lines. Overexpression of LINC01125 in this context not only suppresses cellular proliferation but also enhances cisplatin cytotoxicity by directly binding to miR‑1972 and thereby modulating downstream apoptotic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these findings indicate that LINC01125 functions as a tumor suppressor by regulating key microRNAs and signaling pathways involved in cell proliferation, apoptosis, metastasis, and chemoresistance. Its roles across various cancers underscore its potential as both a diagnostic biomarker and a therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jianfeng Xian, Yuyuan Zeng, Shizhen Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Discovery of a novel linc01125 isoform in serum exosomes as a promising biomarker for NSCLC diagnosis and survival assessment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgab034"}], "href": "https://doi.org/10.1093/carcin/bgab034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33928340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33928340"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Weijun Wan, Yongying Hou, Ke Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-019-1440-5"}], "href": "https://doi.org/10.1038/s41419-019-1440-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30867411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30867411"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Qingqing Li, Hui Yang, Peipei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "XGBoost-based and tumor-immune characterized gene signature for the prediction of metastatic status in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Transl Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12967-022-03369-9"}], "href": "https://doi.org/10.1186/s12967-022-03369-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35436939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35436939"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jia Guo, Hua Pan "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC01125 Enhances Cisplatin Sensitivity of Ovarian Cancer via miR-1972."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Sci Monit (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.12659/MSM.916820"}], "href": "https://doi.org/10.12659/MSM.916820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31865363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31865363"}]}]}]}