{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01314 is a long non‐coding RNA that appears to function as a tumor suppressor in multiple malignancies. In gastric cancer, LINC01314 is downregulated, and its over‐expression leads to a reduction in kallikrein 4 (KLK4) levels. This downregulation of KLK4 results in the suppression of the Wnt/β‐catenin signaling pathway, marked by decreased levels of Wnt-1, β‐catenin, cyclin D1, and N-cadherin, along with an increase in E-cadherin. These molecular changes collectively inhibit cancer cell migration, invasion, and angiogenesis, suggesting a pivotal role for LINC01314 in controlling tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pediatric hepatoblastoma, LINC01314 overexpression similarly exhibits anti-cancer effects. Experimental data reveal that increasing LINC01314 levels suppresses cell proliferation and migration by inhibiting the nuclear translocation of the oncogenic transcriptional co-activator YAP. Mechanistically, LINC01314 induces MST1 expression and promotes the phosphorylation of LATS1 and YAP, thereby downregulating key cell cycle regulatory proteins such as MCM7 and cyclin D1. This regulatory cascade underscores the tumor-suppressive potential of LINC01314 and highlights its promise as both a biomarker and therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, LINC01314 functions as a tumor suppressor by modulating major oncogenic pathways—the Wnt/β‐catenin pathway in gastric cancer and the Hippo-YAP pathway in hepatoblastoma. These findings support further investigation into LINC01314 as a potential target for novel anti-cancer therapies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lin Tang, Jian-Bo Wen, Ping Wen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC01314 represses cell migration, invasion, and angiogenesis in gastric cancer via the Wnt/β-catenin signaling pathway by down-regulating KLK4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0799-9"}], "href": "https://doi.org/10.1186/s12935-019-0799-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31007611"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31007611"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Benji Lv, Lianhai Zhang, Runchen Miao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive analysis and experimental verification of LINC01314 as a tumor suppressor in hepatoblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Pharmacother (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biopha.2018.01.013"}], "href": "https://doi.org/10.1016/j.biopha.2018.01.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29571247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29571247"}]}]}]}