{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a comprehensive analysis of long noncoding RNAs in ovarian cancer, researchers identified hundreds of dysregulated lncRNAs—many of which appear to be altered by genomic copy number changes—and found that several of these RNAs are associated with poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Notably, although the initial query mentioned LINC01330, the study in Abstract"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "specifically investigated LINC00511. The mechanistic experiments revealed that LINC00511 exerts oncogenic functions in ovarian cancer cells by interacting with the histone methyltransferase EZH2 and subsequently repressing the expression of the cell cycle inhibitor P21. This repression likely contributes to enhanced cell proliferation and tumor progression. No functional information on LINC01330 is provided in this abstract.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jing Wang, Yongju Tian, Hui Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An integrated analysis reveals the oncogenic function of lncRNA LINC00511 in human ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.2171"}], "href": "https://doi.org/10.1002/cam4.2171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31016892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31016892"}]}]}]}