{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC01347 is a long non‐coding RNA that demonstrates context‐dependent functions across various pathological conditions. In neuronal cells, lidocaine treatment downregulates LINC01347, while its overexpression clearly mitigates lidocaine‐induced cytotoxicity through attenuating cell death, LDH release, caspase activation, and autophagy; this protective effect is mediated, at least in part, by its interaction with hsa‑miR‑145‑5p (against which LINC01347 acts as a molecular sponge)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, however, elevated LINC01347 expression is associated with advanced disease stage and poor prognosis, where it functions to promote cell proliferation and chemotherapy resistance to 5‑fluorouracil by sponging miR‑328‑5p and thereby regulating LOXL2 expression, identifying it as both a prognostic biomarker and a potential therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In the context of intervertebral disc degeneration, LINC01347 was recognized among a set of characteristic genes associated with the disease, suggesting its involvement in the molecular signature of the condition, although its precise functional role remains to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in ruptured intracranial aneurysm‐induced subarachnoid hemorrhage, LINC01347 appears within a lncRNA–mRNA regulatory network linked to immune response and inflammation, hinting at a potential contribution to the inflammatory milieu associated with the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yana Zhang, Lixin Liu, Peng Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC01347 Modulated Lidocaine-Induced Cytotoxicity in SH-SY5Y Cells by Interacting with hsa-miR-145-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurotox Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12640-021-00363-9"}], "href": "https://doi.org/10.1007/s12640-021-00363-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34115321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34115321"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gui-Li Zheng, Yu-Lin Liu, Ze-Xuan Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Elevated LOXL2 expression by LINC01347/miR-328-5p axis contributes to 5-FU chemotherapy resistance of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Cancer Res (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33948374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33948374"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiaobo Ma, Junqiang Su, Bo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Characteristic Genes in Whole Blood of Intervertebral Disc Degeneration Patients by Weighted Gene Coexpression Network Analysis (WGCNA)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/6609901"}], "href": "https://doi.org/10.1155/2022/6609901"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35069789"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35069789"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lifa Huang, Xu Li, Zupeng Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of inflammation‑associated circulating long non‑coding RNAs and genes in intracranial aneurysm rupture‑induced subarachnoid hemorrhage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11540"}], "href": "https://doi.org/10.3892/mmr.2020.11540"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33174039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33174039"}]}]}]}