LMO4 Gene

Name	LIM domain only 4
Description	This gene encodes a cysteine-rich protein that contains two LIM domains but lacks a DNA-binding homeodomain. The encoded protein may play a role as a transcriptional regulator or as an oncogene. [provided by RefSeq, Aug 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LIM domain only 4 (LMO4) is emerging as a multifunctional transcriptional coregulator that plays diverse roles in both neural development and disease. In the nervous system, LMO4 integrates calcium‐dependent signals to regulate gene transcription critical for neurite outgrowth, thalamocortical connection patterning, and synaptic plasticity, thereby influencing sensorimotor performance and learning."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Moreover, LMO4 enhances neuroprotective signaling—such as potentiating Stat3 activation following granulocyte colony‐stimulating factor (GCSF) treatment—further supporting its role in neuronal survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition to its functions in cortical and subcortical neurons, LMO4 is pivotal in hypothalamic signaling where it modulates leptin action and thereby contributes to the regulation of energy balance and fat metabolism. Altered LMO4 activity in key hypothalamic nuclei disrupts leptin signaling and neuronal excitability, leading to metabolic imbalances and hyperphagia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n At the molecular level, LMO4 serves as a hub that orchestrates the assembly of multiprotein transcription complexes. It interacts with partners such as CREB, LIM domain–interacting proteins, and histone deacetylases to modulate gene expression, including the negative regulation of estrogen receptor α transactivation functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of oncogenesis, LMO4 is frequently upregulated and appears to promote tumor progression by enhancing cell proliferation, invasion, and epithelial-to-mesenchymal transitions. Elevated LMO4 expression has been implicated in breast, pancreatic, gastric, and neuroblastoma cancers through its modulation of signaling pathways—including PI3K/Akt/mTOR and estrogen receptor–dependent mechanisms—that drive oncogenic processes."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "11", "end_ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, post‐translational modifications of LMO4 have been linked to cellular stress responses. In conditions of nitroxidative stress—such as those induced by cisplatin—LMO4 undergoes nitration, which correlates with its downregulation and is associated with cochlear cell apoptosis and hearing loss. Interventions that prevent LMO4 nitration have been shown to mitigate cisplatin-induced ototoxicity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "18"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies establish LMO4 as a critical, context-dependent regulator that influences neuronal development, synaptic function, metabolic homeostasis, and tumorigenesis. Its ability to act as a molecular hub in transcriptional networks underlines the complexity of its regulation and highlights its potential as a therapeutic target in diverse pathophysiological conditions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amir H Kashani, Zilong Qiu, Linda Jurata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0618-06.2006"}], "href": "https://doi.org/10.1523/JNEUROSCI.0618-06.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16899735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16899735"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhaohong Qin, Xun Zhou, Mariana Gomez-Smith, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.6271-11.2012"}], "href": "https://doi.org/10.1523/JNEUROSCI.6271-11.2012"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22442089"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22442089"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Zhenyong Huang, Yoko Kawase-Koga, Shuqun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Biol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ydbio.2008.12.003"}], "href": "https://doi.org/10.1016/j.ydbio.2008.12.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19111533"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19111533"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gregor Schaffar, Junko Taniguchi, Tanja Brodbeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2008.05621.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2008.05621.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18702663"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18702663"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Mariana Gomez-Smith, Zhaohong Qin, Xun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM domain only 4 protein promotes granulocyte colony-stimulating factor-induced signaling in neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-009-0223-z"}], "href": "https://doi.org/10.1007/s00018-009-0223-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19997957"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19997957"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nihar R Pandey, Xun Zhou, Zhaohong Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LIM domain only 4 protein is a metabolic responsive inhibitor of protein tyrosine phosphatase 1B that controls hypothalamic leptin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0746-13.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.0746-13.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23904601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23904601"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xun Zhou, Mariana Gomez-Smith, Zhaohong Qin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ablation of LMO4 in glutamatergic neurons impairs leptin control of fat metabolism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-011-0794-3"}], "href": "https://doi.org/10.1007/s00018-011-0794-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21874351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21874351"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Tariq Zaman, Xun Zhou, Nihar R Pandey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.3419-13.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.3419-13.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24381275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24381275"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Soumya Joseph, Ann H Kwan, Philippa H Stokes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0109108"}], "href": "https://doi.org/10.1371/journal.pone.0109108"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25310299"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25310299"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Rajesh R Singh, Christopher J Barnes, Amjad H Talukder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-05-2268"}], "href": "https://doi.org/10.1158/0008-5472.CAN-05-2268"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16288053"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16288053"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Xiang Xiong, Yeqian Feng, Lun Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non‑coding RNA SNHG1 promotes breast cancer progression by regulation of LMO4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2020.7530"}], "href": "https://doi.org/10.3892/or.2020.7530"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32323846"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32323846"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jun Yu, Kenoki Ohuchida, Kohei Nakata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LIM only 4 is overexpressed in late stage pancreas cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1476-4598-7-93"}], "href": "https://doi.org/10.1186/1476-4598-7-93"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19099607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19099607"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ning Wang, Qing Dong, Xiao-Na Zhou "}, {"type": "b", "children": [{"type": "t", "text": "LMO4 promotes the invasion and proliferation of gastric cancer by activating PI3K-Akt-mTOR signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2019)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31737204"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31737204"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Tiago Ferronha, M Angeles Rabadán, Estel Gil-Guiñon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.4511-12.2013"}], "href": "https://doi.org/10.1523/JNEUROSCI.4511-12.2013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23407937"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23407937"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "J E Visvader, D Venter, K Hahm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.251547698"}], "href": "https://doi.org/10.1073/pnas.251547698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11734645"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11734645"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Samson Jamesdaniel, Rajamani Rathinam, William L Neumann "}, {"type": "b", "children": [{"type": "t", "text": "Targeting nitrative stress for attenuating cisplatin-induced downregulation of cochlear LIM domain only 4 and ototoxicity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Redox Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.redox.2016.10.016"}], "href": "https://doi.org/10.1016/j.redox.2016.10.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27821327"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27821327"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Samson Jamesdaniel, Donald Coling, Sneha Hinduja, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cisplatin-induced ototoxicity is mediated by nitroxidative modification of cochlear proteins characterized by nitration of Lmo4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.297960"}], "href": "https://doi.org/10.1074/jbc.M111.297960"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22493493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22493493"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Rita Rosati, Monazza Shahab, Vickram Ramkumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lmo4 Deficiency Enhances Susceptibility to Cisplatin-Induced Cochlear Apoptosis and Hearing Loss."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-020-02226-4"}], "href": "https://doi.org/10.1007/s12035-020-02226-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33411315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33411315"}]}]}]}
Proteins	LMO4_HUMAN
NCBI Gene ID	8543
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LMO4 has 7,598 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 109 datasets.

Click the + buttons to view associations for LMO4 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LMO4 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by LMO4 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMO4 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMO4 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LMO4 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LMO4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LMO4 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMO4 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LMO4 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LMO4 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LMO4 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LMO4 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LMO4 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LMO4 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LMO4 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LMO4 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LMO4 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing LMO4 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LMO4 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LMO4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LMO4 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LMO4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LMO4 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing LMO4 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LMO4 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LMO4 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with LMO4 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LMO4 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LMO4 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LMO4 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LMO4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LMO4 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LMO4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LMO4 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LMO4 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LMO4 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LMO4 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LMO4 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with LMO4 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with LMO4 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of LMO4 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.