LMO7 Gene

Name	LIM domain 7
Description	This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LMO7 is a multifunctional protein that plays context‐dependent roles in regulating nuclear structure, gene expression, and cytoskeletal organization. In muscle cells, LMO7 interacts with the inner nuclear membrane protein emerin and contributes to the transcriptional activation of key myogenic genes such as MyoD, Myf5, Pax3, and Pax7, implicating it in the pathogenesis of Emery–Dreifuss muscular dystrophy (EDMD)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In chick skeletal myogenesis, for example, LMO7 localizes to both nuclei and perinuclear regions to promote myoblast survival and differentiation—a function that can be modulated via Wnt/β‐catenin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In contrast, mouse knockout studies suggest that, at least in certain mammalian models, LMO7 may be dispensable for normal skeletal and cardiac muscle physiology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In epithelial and cancer contexts, LMO7 appears to act as a tumor suppressor. In lung cancer, for instance, LMO7 is targeted by miR‑96, and reduced LMO7 expression is associated with enhanced cell viability, migration, and chemoresistance, while its down‐regulation in malignant lung tissue correlates with unfavorable prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, novel oncogenic fusions involving LMO7—such as LMO7–BRAF in thyroid cancer and LMO7–ALK in non‑small cell lung cancer—underscore its potential involvement in tumorigenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " In the setting of liver injury and fibrosis, increased LMO7 expression following bone mesenchymal stem cell transplantation is associated with reduced TGF‑β signaling via inhibition of the AP‑1 transcription factor, suggesting an antifibrotic role."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Collectively, these findings reveal that LMO7 functions as a regulatory node integrating signals from the nuclear envelope and the actin cytoskeleton to influence cell differentiation, tissue homeostasis, and tumor progression.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "James M Holaska, Soroush Rais-Bahrami, Katherine L Wilson "}, {"type": "b", "children": [{"type": "t", "text": "Lmo7 is an emerin-binding protein that regulates the transcription of emerin and many other muscle-relevant genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddl423"}], "href": "https://doi.org/10.1093/hmg/ddl423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17067998"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17067998"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zinaida Dedeic, Maureen Cetera, Tatiana V Cohen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.080259"}], "href": "https://doi.org/10.1242/jcs.080259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21525034"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21525034"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ana C B Possidonio, Carolina P Soares, Marcio Fontenele, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Knockdown of Lmo7 inhibits chick myogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1873-3468.12067"}], "href": "https://doi.org/10.1002/1873-3468.12067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26786059"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26786059"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Dieu Hung Lao, Mary C Esparza, Shannon N Bremner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lmo7 is dispensable for skeletal muscle and cardiac function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00177.2015"}], "href": "https://doi.org/10.1152/ajpcell.00177.2015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26157009"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26157009"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hao Wu, Jingcheng Zhou, Shanshan Mei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Circulating exosomal microRNA-96 promotes cell proliferation, migration and drug resistance by targeting LMO7."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.13056"}], "href": "https://doi.org/10.1111/jcmm.13056"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28026121"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28026121"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Terese Karlsson, Samuel Kvarnbrink, Camilla Holmlund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Lung Cancer (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.lungcan.2018.09.017"}], "href": "https://doi.org/10.1016/j.lungcan.2018.09.017"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30429017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30429017"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Huiling He, Wei Li, Pearlly Yan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of a Recurrent LMO7-BRAF Fusion in Papillary Thyroid Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thyroid (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1089/thy.2017.0258"}], "href": "https://doi.org/10.1089/thy.2017.0258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29768105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29768105"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Mengnan Li, Zhou An, Qiusu Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mixed responses to first-line alectinib in non-small cell lung cancer patients with rare ALK gene fusions: A case series and literature review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16897"}], "href": "https://doi.org/10.1111/jcmm.16897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34541785"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34541785"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Z-K Chen, D-Z Chen, C Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BMSCs attenuate hepatic fibrosis in autoimmune hepatitis through regulation of LMO7-AP1-TGFβ signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202102_24870"}], "href": "https://doi.org/10.26355/eurrev_202102_24870"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33629329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33629329"}]}]}]}
Synonyms	FBX20, LOMP, FBXO20
Proteins	LMO7_HUMAN
NCBI Gene ID	4008
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LMO7 has 7,001 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for LMO7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LMO7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by LMO7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMO7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMO7 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LMO7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LMO7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMO7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LMO7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LMO7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LMO7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LMO7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LMO7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LMO7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LMO7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LMO7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LMO7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LMO7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LMO7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LMO7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LMO7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing LMO7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing LMO7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LMO7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LMO7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing LMO7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LMO7 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LMO7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LMO7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LMO7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with LMO7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LMO7 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LMO7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with LMO7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LMO7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LMO7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LMO7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LMO7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LMO7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LMO7 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LMO7 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LMO7 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.