LMTK2 Gene

HGNC Family	Receptor kinases, Protein phosphatase 1 regulatory subunits (PPP1R)
Name	lemur tyrosine kinase 2
Description	The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Lemur tyrosine kinase 2 (LMTK2) is emerging as a multifunctional, membrane‐anchored serine/threonine kinase with diverse roles in both cancer and neuronal cells. In prostate cancer, genome‐wide studies have implicated LMTK2 as a candidate susceptibility gene, and its expression is notably reduced in tumors compared with benign tissue. Moreover, loss of LMTK2 has been linked to enhanced androgen receptor signaling and increased transcription of androgen‐responsive genes, suggesting that LMTK2 normally functions as a negative regulator of androgen receptor activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n LMTK2 also plays an essential role in intracellular membrane trafficking. It is recruited to endosomal compartments through interactions with the actin‐based motor myosin VI, and this partnership is required for the proper transport of cargo such as transferrin receptor and for efficient recycling of membrane proteins. Disruption of LMTK2’s interaction with myosin VI—as seen in mutants affecting its WWY–binding motif or di‐acidic ER export signal—leads to protein mislocalization, interference with endocytic recycling and perturbation of secretion in cancer cells."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LMTK2 directly phosphorylates key substrates to regulate their cell surface expression. For example, LMTK2 phosphorylates the cystic fibrosis transmembrane conductance regulator (CFTR) at Ser737, thereby attenuating its endocytosis and reducing CFTR plasma membrane density, and these findings are supported by studies using both direct kinase assays and peptide library analyses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the nervous system, LMTK2 is a component of signaling complexes that modulate neuronal function. It phosphorylates protein phosphatase-1 at Thr320 to inhibit its activity, and its own activity is regulated by phosphorylation through cdk5/p35. Furthermore, LMTK2 interacts with kinesin light chain to facilitate the axonal transport of cdk5/p35, while reduced LMTK2 expression in Alzheimer’s disease brains, as well as its neuroprotective effects in oxygen–glucose deprivation models, point to a role in maintaining neuronal survival and function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "15"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond these roles, LMTK2 has been implicated in other malignancies. In hepatocellular carcinoma, elevated expression of LMTK2 is associated with activation of the Wnt/β-catenin pathway via modulation of GSK-3β phosphorylation, which enhances cell proliferation and invasion. Similarly, a circular RNA derived from the LMTK2 transcript (circLMTK2) acts as an oncogenic promoter in gastric cancer by sponging miR-150-5p to upregulate c-Myc expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, mutations in LMTK2 have also been detected in pulmonary sarcomatoid carcinoma, broadening its relevance as a cancer-associated gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Rosalind A Eeles, Zsofia Kote-Jarai, Graham G Giles, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Multiple newly identified loci associated with prostate cancer susceptibility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.90"}], "href": "https://doi.org/10.1038/ng.90"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18264097"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18264097"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Kevin M Waters, Loic Le Marchand, Laurence N Kolonel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Generalizability of associations from prostate cancer genome-wide association studies in multiple populations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Epidemiol Biomarkers Prev (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1055-9965.EPI-08-1142"}], "href": "https://doi.org/10.1158/1055-9965.EPI-08-1142"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19318432"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19318432"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lorna W Harries, John R B Perry, Paul McCullagh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Alterations in LMTK2, MSMB and HNF1B gene expression are associated with the development of prostate cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-10-315"}], "href": "https://doi.org/10.1186/1471-2407-10-315"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20569440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20569440"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Kalpit Shah, Neil A Bradbury "}, {"type": "b", "children": [{"type": "t", "text": "Lemur Tyrosine Kinase 2, a novel target in prostate cancer therapy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.3899"}], "href": "https://doi.org/10.18632/oncotarget.3899"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26008968"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26008968"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Margarita V Chibalina, Matthew N J Seaman, Christopher C Miller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.014217"}], "href": "https://doi.org/10.1242/jcs.014217"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18029400"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18029400"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Takeshi Inoue, Takahide Kon, Reiko Ohkura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BREK/LMTK2 is a myosin VI-binding protein involved in endosomal membrane trafficking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Cells (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2443.2008.01184.x"}], "href": "https://doi.org/10.1111/j.1365-2443.2008.01184.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18429820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18429820"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "C Puri, M V Chibalina, S D Arden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of myosin VI in prostate cancer cells enhances PSA and VEGF secretion, but has no effect on endocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.328"}], "href": "https://doi.org/10.1038/onc.2009.328"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19855435"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19855435"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Susan D Arden, David A Tumbarello, Tariq Butt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Loss of cargo binding in the human myosin VI deafness mutant (R1166X) leads to increased actin filament binding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BCJ20160571"}], "href": "https://doi.org/10.1042/BCJ20160571"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27474411"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27474411"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "E C Butler, Neil A Bradbury "}, {"type": "b", "children": [{"type": "t", "text": "Signal dependent ER export of lemur tyrosine kinase 2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cell Biol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12860-015-0072-6"}], "href": "https://doi.org/10.1186/s12860-015-0072-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26559041"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26559041"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Simão Luz, Kristine M Cihil, David L Brautigan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LMTK2-mediated phosphorylation regulates CFTR endocytosis in human airway epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.563742"}], "href": "https://doi.org/10.1074/jbc.M114.563742"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24727471"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24727471"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Hong Wang, David L Brautigan "}, {"type": "b", "children": [{"type": "t", "text": "Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Proteomics (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/mcp.M600188-MCP200"}], "href": "https://doi.org/10.1074/mcp.M600188-MCP200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16887929"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16887929"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Catherine Manser, Alessio Vagnoni, Florence Guillot, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cdk5/p35 phosphorylates lemur tyrosine kinase-2 to regulate protein phosphatase-1C phosphorylation and activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurochem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1471-4159.2012.07650.x"}], "href": "https://doi.org/10.1111/j.1471-4159.2012.07650.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22220831"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22220831"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Gábor M Mórotz, Elizabeth B Glennon, Patricia Gomez-Suaga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LMTK2 binds to kinesin light chains to mediate anterograde axonal transport of cdk5/p35 and LMTK2 levels are reduced in Alzheimer's disease brains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Neuropathol Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40478-019-0715-5"}], "href": "https://doi.org/10.1186/s40478-019-0715-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31068217"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31068217"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "János Bencze, Máté Szarka, Viktor Bencs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Neuropathological characterization of Lemur tyrosine kinase 2 (LMTK2) in Alzheimer's disease and neocortical Lewy body disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-53638-9"}], "href": "https://doi.org/10.1038/s41598-019-53638-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31748522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31748522"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hong Bao, Min Gao "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of lemur tyrosine kinase-2 protects neurons from oxygen-glucose deprivation/reoxygenation-induced injury through reinforcement of Nrf2 signaling by modulating GSK-3β phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.11.002"}], "href": "https://doi.org/10.1016/j.bbrc.2019.11.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31722791"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31722791"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gang Zhao, Yahua Song, Lei Dong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of lemur tyrosine kinase 2 restricts the proliferation and invasion of hepatocellular carcinoma through modulation of GSK-3β/Wnt/β-catenin signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.07.122"}], "href": "https://doi.org/10.1016/j.bbrc.2019.07.122"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31395338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31395338"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sen Wang, Dong Tang, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12943-019-1081-4"}], "href": "https://doi.org/10.1186/s12943-019-1081-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31722712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31722712"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Xuewen Liu, Yuxia Jia, Mark B Stoopler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Next-Generation Sequencing of Pulmonary Sarcomatoid Carcinoma Reveals High Frequency of Actionable MET Gene Mutations."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2015.62.0674"}], "href": "https://doi.org/10.1200/JCO.2015.62.0674"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26215952"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26215952"}]}]}]}
Synonyms	BREK, AATYK2, KPI2, LMR2, KPI-2, PPP1R100, CPRK, hBREK
Proteins	LMTK2_HUMAN
NCBI Gene ID	22853
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LMTK2 has 6,893 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for LMTK2 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LMTK2 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMTK2 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMTK2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LMTK2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LMTK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LMTK2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LMTK2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LMTK2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LMTK2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LMTK2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LMTK2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LMTK2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LMTK2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with LMTK2 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LMTK2 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LMTK2 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LMTK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LMTK2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing LMTK2 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LMTK2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LMTK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LMTK2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing LMTK2 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LMTK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LMTK2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LMTK2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LMTK2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LMTK2 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LMTK2 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with LMTK2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LMTK2 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LMTK2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with LMTK2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LMTK2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LMTK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LMTK2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LMTK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LMTK2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LMTK2 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LMTK2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LMTK2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.