LPAR6 Gene

HGNC Family	G protein-coupled receptors
Name	lysophosphatidic acid receptor 6
Description	The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LPAR6, also known as P2Y5, is an atypical lysophosphatidic acid (LPA) receptor that plays a pivotal role in hair follicle homeostasis as well as in cancer progression. Genetic studies have demonstrated that homozygous mutations in the P2RY5 gene underlie autosomal recessive forms of hair disorders—including hypotrichosis simplex and woolly hair—thereby establishing an essential function for LPAR6 in maintaining proper hair growth and follicle integrity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " In normal hair follicles, LPAR6 is expressed prominently in the inner root sheath, where activation by LPA—generated via the enzyme PA‐PLA₁α (LIPH)—initiates downstream signaling cascades, including a TACE–TGFα–EGFR pathway that regulates differentiation and maturation of the follicle."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In addition to its role in hair biology, aberrant overexpression of LPAR6 has been linked to hepatocellular carcinoma, where it supports tumorigenesis and cellular proliferation through the transcriptional upregulation of oncogenic targets such as Pim‐3 in a STAT3‐dependent manner."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Collectively, these findings underscore LPAR6 as a critical mediator of LPA signaling—with fundamental roles in both the maintenance of hair follicle integrity and the progression of certain cancers—and highlight its potential as a therapeutic target in hair disorders and malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sandra M Pasternack, Ivar von Kügelgen, Khalid Al Aboud, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.84"}], "href": "https://doi.org/10.1038/ng.84"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18297070"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18297070"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yutaka Shimomura, Muhammad Wajid, Yoshiyuki Ishii, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.100"}], "href": "https://doi.org/10.1038/ng.100"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18297072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18297072"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yutaka Shimomura, Maria C Garzon, Leonard Kristal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Autosomal recessive woolly hair with hypotrichosis caused by a novel homozygous mutation in the P2RY5 gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0625.2008.00788.x"}], "href": "https://doi.org/10.1111/j.1600-0625.2008.00788.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18803659"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18803659"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M Tariq, M Ayub, M Jelani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations in the P2RY5 gene underlie autosomal recessive hypotrichosis in 13 Pakistani families."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Dermatol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1365-2133.2009.09046.x"}], "href": "https://doi.org/10.1111/j.1365-2133.2009.09046.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19292720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19292720"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Asuka Inoue, Naoaki Arima, Jun Ishiguro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/emboj.2011.296"}], "href": "https://doi.org/10.1038/emboj.2011.296"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21857648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21857648"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Antonio Mazzocca, Francesco Dituri, Flavia De Santis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lysophosphatidic acid receptor LPAR6 supports the tumorigenicity of hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-14-1607"}], "href": "https://doi.org/10.1158/0008-5472.CAN-14-1607"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25589345"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25589345"}]}]}]}
Synonyms	LAH3, ARWH1, HYPT8, P2Y5, P2RY5
Proteins	LPAR6_HUMAN
NCBI Gene ID	10161
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LPAR6 has 8,423 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 113 datasets.

Click the + buttons to view associations for LPAR6 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LPAR6 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPAR6 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPAR6 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LPAR6 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LPAR6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LPAR6 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPAR6 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LPAR6 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LPAR6 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LPAR6 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of LPAR6 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LPAR6 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LPAR6 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LPAR6 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LPAR6 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LPAR6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LPAR6 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with LPAR6 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of LPAR6 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LPAR6 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LPAR6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LPAR6 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LPAR6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LPAR6 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LPAR6 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LPAR6 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LPAR6 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LPAR6 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LPAR6 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DGIdb Drug Targets 2026	interacting drugs for LPAR6 protein from the DGIdb Drug Targets 2026 dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving LPAR6 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving LPAR6 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LPAR6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LPAR6 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LPAR6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LPAR6 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LPAR6 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LPAR6 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LPAR6 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LPAR6 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of LPAR6 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.