LPGAT1 Gene

Name	lysophosphatidylglycerol acyltransferase 1
Description	This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is a microsomal enzyme that catalyzes the acylation of lysophosphatidylglycerol (LPG), thereby mediating the remodeling of phosphatidylglycerol (PG) to generate species with a specific acyl chain composition. Initial characterization of LPGAT1 demonstrated that it preferentially uses long‐chain saturated fatty acyl‐CoAs, such as oleoyl‐CoA, exhibiting substrate specificity in converting LPG into PG and shielding the cell from the potentially harmful accumulation of lysophosphatidylglycerol."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Subsequent studies revealed that LPGAT1 is not only central to maintaining phospholipid homeostasis but also plays a pivotal role in lipid biosynthesis within the liver. LPGAT1 expression correlates with hepatic microsomal triglyceride transfer activity and its manipulation through gene knockdown experiments has been shown to significantly reduce serum triacylglycerol and cholesterol secretion, underscoring its role in hepatic triacylglycerol synthesis and secretion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, LPGAT1 has emerged as an important candidate gene influencing overall energy homeostasis and body mass index. Genetic association studies have identified variants—including a novel 27‐base pair deletion in the 5′-untranslated region—that correlate with increased BMI and altered transcriptional or posttranscriptional regulation, suggesting that LPGAT1 contributes to obesity susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LPGAT1 functions as an sn-1–specific acyltransferase that controls the stearate/palmitate ratio in major phospholipids such as phosphatidylethanolamine and phosphatidylcholine. Genetic ablation of LPGAT1 in mice leads to a significant shift in lipid composition, decreased total lipid synthesis, reduced body fat, and even impacts longevity, which highlights its central regulatory role in membrane lipid remodeling and energy metabolism."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, whole-body knockout studies indicate that while LPGAT1 deficiency can protect against diet-induced obesity, it simultaneously predisposes to liver pathology, insulin resistance, and nonalcoholic fatty liver disease as a consequence of oxidative stress and mitochondrial dysfunction. These findings firmly establish LPGAT1 as a key modulator linking mitochondrial PG remodeling to systemic metabolic function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yanzhu Yang, Jingsong Cao, Yuguang Shi "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M406710200"}], "href": "https://doi.org/10.1074/jbc.M406710200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15485873"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15485873"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yasushi Hiramine, Hisayo Emoto, Shunsuke Takasuga, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel acyl-coenzyme A:monoacylglycerol acyltransferase plays an important role in hepatic triacylglycerol secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M002584"}], "href": "https://doi.org/10.1194/jlr.M002584"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20018982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20018982"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael T Traurig, Julieanna I Orczewska, Daniel J Ortiz, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Obesity (Silver Spring) (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/oby.20243"}], "href": "https://doi.org/10.1002/oby.20243"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23505186"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23505186"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yang Xu, Paighton C Miller, Colin K L Phoon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jbc.2022.101685"}], "href": "https://doi.org/10.1016/j.jbc.2022.101685"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35131264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35131264"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xiaoyang Zhang, Jun Zhang, Haoran Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Defective Phosphatidylglycerol Remodeling Causes Hepatopathy, Linking Mitochondrial Dysfunction to Hepatosteatosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Gastroenterol Hepatol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jcmgh.2019.02.002"}], "href": "https://doi.org/10.1016/j.jcmgh.2019.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30831319"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30831319"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lingyang Xu, Liu Yang, Bo Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide scan reveals genetic divergence and diverse adaptive selection in Chinese local cattle."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-019-5822-y"}], "href": "https://doi.org/10.1186/s12864-019-5822-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31200634"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31200634"}]}]}]}
Synonyms	NET8, FAM34A, FAM34A1
Proteins	LGAT1_HUMAN
NCBI Gene ID	9926
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LPGAT1 has 6,162 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for LPGAT1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LPGAT1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by LPGAT1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPGAT1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LPGAT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LPGAT1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPGAT1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LPGAT1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LPGAT1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LPGAT1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LPGAT1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LPGAT1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LPGAT1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LPGAT1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LPGAT1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LPGAT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LPGAT1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LPGAT1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LPGAT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LPGAT1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing LPGAT1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LPGAT1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LPGAT1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LPGAT1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with LPGAT1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of LPGAT1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LPGAT1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LPGAT1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LPGAT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LPGAT1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LPGAT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LPGAT1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LPGAT1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LPGAT1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LPGAT1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LPGAT1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of LPGAT1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with LPGAT1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing LPGAT1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of LPGAT1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of LPGAT1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of LPGAT1 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.