LPXN Gene

Name	leupaxin
Description	The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Leupaxin (LPXN) is a focal adhesion adaptor protein belonging to the paxillin family that integrates extracellular cues with intracellular cytoskeletal dynamics and gene regulation. In osteoclasts, LPXN associates with kinases such as PYK2 and Src and phosphatases like PTP‐PEST to organize podosomal signaling complexes, thereby modulating adhesion, cell spreading, and bone resorptive activity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In prostate cancer cells, LPXN forms signaling complexes with Pyk2, c‐Src, and PTP‐PEST that influence Rho GTPase activity and promote cell migration and invasion, while its aberrant expression and nuclear shuttling also enable interaction with steroid hormone receptors to potentiate transcriptional programs driving tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in bladder and breast cancers, elevated LPXN levels correlate with enhanced proliferative and invasive behavior through its involvement in the PI3K/AKT pathway and through functioning as a coactivator for estrogen receptors."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " LPXN also translocates to focal adhesions in response to receptor activation—such as by bombesin—where its tyrosine phosphorylation modulates adhesion and spreading."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hematopoietic and myeloid cells, LPXN is highly expressed and interacts with signaling molecules such as the PEST domain tyrosine phosphatase to modulate antigen receptor signaling in lymphocytes, while in macrophages and other myeloid cells its regulatory role contributes to adhesion, polarization, and phagocytosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "10"}]}, {"type": "t", "text": " Moreover, in hepatocellular carcinoma, LPXN can act as a transcriptional coactivator for β‐catenin, enhancing the expression of oncogenes, and fusion proteins involving LPXN have been implicated in leukemogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " Finally, in B cells LPXN is the predominantly expressed paxillin family member, suggesting a key role in integrin signaling and possibly in modulating immune functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies underscore LPXN’s multifaceted role as a scaffold that orchestrates integrin‐mediated adhesion, cytoskeletal reorganization, and transcriptional regulation in diverse cellular contexts—ranging from bone resorption and immune cell function to cancer cell migration and invasion.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Anandarup Gupta, Beth S Lee, Mohammed A Khadeer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Bone Miner Res (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1359/jbmr.2003.18.4.669"}], "href": "https://doi.org/10.1359/jbmr.2003.18.4.669"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12674328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12674328"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Surasri Nandan Sahu, Mohammed Abdul Khadeer, Brian W Robertson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of leupaxin with Src in osteoclasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00636.2005"}], "href": "https://doi.org/10.1152/ajpcell.00636.2005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16914530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16914530"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Surasri Nandan Sahu, Stephanie Nunez, Guang Bai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Cell Physiol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajpcell.00503.2006"}], "href": "https://doi.org/10.1152/ajpcell.00503.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17329398"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17329398"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Silke Kaulfuss, Michal Grzmil, Bernhard Hemmerlein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin, a novel coactivator of the androgen receptor, is expressed in prostate cancer and plays a role in adhesion and invasion of prostate carcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2006-0546"}], "href": "https://doi.org/10.1210/me.2006-0546"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18451096"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18451096"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Teng Hou, Lijie Zhou, Longwang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin Promotes Bladder Cancer Proliferation, Metastasis, and Angiogenesis Through the PI3K/AKT Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Physiol Biochem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000491536"}], "href": "https://doi.org/10.1159/000491536"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29975926"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29975926"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Silke Kaulfuss, Anna-Maria Herr, Anja Büchner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin is expressed in mammary carcinoma and acts as a transcriptional activator of the estrogen receptor α."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2015.2988"}], "href": "https://doi.org/10.3892/ijo.2015.2988"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25955236"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25955236"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Pei-Wen Chen, Glenn S Kroog "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Adh Migr (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cam.4.4.12399"}], "href": "https://doi.org/10.4161/cam.4.4.12399"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20543562"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20543562"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Noriyuki Watanabe, Natsuko Amano, Hajime Ishizuka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin binds to PEST domain tyrosine phosphatase PEP."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-005-2149-6"}], "href": "https://doi.org/10.1007/s11010-005-2149-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15786712"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15786712"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Huan Liu, Liang Zhu, Tejasvi Dudiki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Macrophage Migration and Phagocytosis Are Controlled by Kindlin-3's Link to the Cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1901134"}], "href": "https://doi.org/10.4049/jimmunol.1901134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32094207"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32094207"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Michael W Murrey, James H Steer, Eloise L Greenland, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Adhesion, motility and matrix-degrading gene expression changes in CSF-1-induced mouse macrophage differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.232405"}], "href": "https://doi.org/10.1242/jcs.232405"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32005697"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32005697"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Jia Shi, Wen-Jie Wu, Gang Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of β-catenin transcription activity by leupaxin in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4060-4"}], "href": "https://doi.org/10.1007/s13277-015-4060-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26361959"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26361959"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hai-Ping Dai, Yong-Quan Xue, Jian-Wei Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LPXN, a member of the paxillin superfamily, is fused to RUNX1 in an acute myeloid leukemia patient with a t(11;21)(q12;q22) translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20704"}], "href": "https://doi.org/10.1002/gcc.20704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19760607"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19760607"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Amélie Bonaud, Simon Clare, Valeria Bisio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leupaxin Expression Is Dispensable for B Cell Immune Responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Immunol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fimmu.2020.00466"}], "href": "https://doi.org/10.3389/fimmu.2020.00466"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32269569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32269569"}]}]}]}
Synonyms	LDPL
Proteins	LPXN_HUMAN
NCBI Gene ID	9404
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

LPXN has 7,375 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 114 datasets.

Click the + buttons to view associations for LPXN from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

LPXN Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPXN gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPXN gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of LPXN gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of LPXN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of LPXN gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of LPXN gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of LPXN gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LPXN gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of LPXN gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of LPXN gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of LPXN gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with LPXN protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with LPXN gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LPXN gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of LPXN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of LPXN gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing LPXN protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of LPXN gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing LPXN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing LPXN protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing LPXN protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with LPXN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with LPXN protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of LPXN gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with LPXN gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with LPXN gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with LPXN gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by LPXN gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with LPXN gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with LPXN gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with LPXN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with LPXN gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with LPXN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with LPXN gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at LPXN gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of LPXN gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of LPXN gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing LPXN from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD High Level Gene-Disease Associations	diseases associated with LPXN gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of LPXN gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.