{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Leucine‐rich repeat–containing protein 46 (LRRC46) is emerging as a gene of interest across multiple biological contexts. Evolutionary conservation studies have identified LRRC46 as one of a few novel testicular genes that had not been previously characterized in the testes, suggesting that it may be involved in reproductive functions or germ cell development (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, LRRC46 has been correlated with imaging phenotypes in glioblastoma, where its expression was associated with specific radiographic tumor features, hinting at a role in tumor biology (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Its downregulation in nasopharyngeal carcinoma further supports its potential as a diagnostic marker in cancer (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, increased expression of LRRC46 in endometrial tissue has been integrated into a five‐gene classifier that effectively distinguishes ectopic pregnancies from abnormal intrauterine pregnancies, an observation that underscores a possible involvement of LRRC46 in ciliary function (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Complementing these findings, transcriptome‐wide association studies in high‐grade serous ovarian cancer have identified LRRC46 as a susceptibility gene, further implying its relevance in oncogenic processes (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these diverse studies suggest that LRRC46 may function in reproductive tissue development and ciliary biology, while also contributing to tumor characterization and cancer susceptibility. Further functional investigations will be essential to elucidate the underlying mechanisms and to determine the full spectrum of LRRC46’s roles in health and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sophie Fouchécourt, Floriane Picolo, Sébastien Elis, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Multi-stage Association Analysis of Glioblastoma Gene Expressions with Texture and Spatial Patterns."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Brainlesion (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/978-3-030-11723-8_24"}], "href": "https://doi.org/10.1007/978-3-030-11723-8_24"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31482151"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31482151"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kai Xue, Jinfeng Cao, Yinan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cts.12690"}], "href": "https://doi.org/10.1111/cts.12690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31863646"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31863646"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jessica A Lentscher, Zachary T Colburn, Nicole Ortogero, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An intrauterine genomic classifier reliably delineates the location of nonviable pregnancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Fertil Steril (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.fertnstert.2021.02.005"}], "href": "https://doi.org/10.1016/j.fertnstert.2021.02.005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33771330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33771330"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alexander Gusev, Kate Lawrenson, Xianzhi Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A transcriptome-wide association study of high-grade serous epithelial ovarian cancer identifies new susceptibility genes and splice variants."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41588-019-0395-x"}], "href": "https://doi.org/10.1038/s41588-019-0395-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31043753"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31043753"}]}]}]}