{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Leucine‐rich repeat–containing protein 70 (LRRC70) belongs to a versatile family of proteins characterized by LRR motifs that mediate protein–protein interactions critical for cellular homeostasis. Insights drawn from structurally and functionally related proteins suggest a multifaceted role for LRRC70. For example, the endoplasmic reticulum (ER) protein SEL1L—with its LRR domains facilitating homodimerization and substrate selection in ER‐associated degradation ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "]—illustrates how LRR regions can govern complex assembly and quality control. Similarly, the transmembrane LRR protein synleurin has been shown to amplify responses to cytokines and growth factors ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "], while broad cataloging of extracellular LRR proteins has underscored their roles in innate immunity and neural development ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "]. Although LRRC70 itself has yet to be directly implicated in specific pathological conditions, studies on retinal degeneration models ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "], novel immunotherapeutic targets in leukemias ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "], and investigations into regulatory noncoding RNAs ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "], along with research into ER organizational proteins ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "] and studies of tissue‐specific gene expression in reproductive ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "] and musculoskeletal systems ["}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "], highlight the central importance of LRR‐mediated interactions. By extrapolation from these diverse findings, LRRC70 is likely to function as an adaptor or scaffolding molecule that coordinates extracellular ligand binding and intracellular signaling, thereby contributing to processes such as protein quality control, immune regulation, and organ-specific cellular responses. Further experimental investigation is warranted to precisely define its mechanistic roles in physiology and disease.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hanbin Jeong, Hyo Jung Sim, Eun Kyung Song, et al. 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