{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies indicate that CD302—a C‐type lectin receptor often discussed alongside LY75 (DEC205)—exhibits multifunctional roles in regulating both immune responses and developmental processes. In the context of innate immunity, CD302 is predominantly expressed on myeloid cells, including dendritic cells, macrophages, granulocytes, and myeloid dendritic cell subsets. Its localization to dynamic cell structures (such as podosomes and lamellopodia) suggests a key function in mediating cell adhesion and migration, as demonstrated by reduced migratory capacity of dendritic cells in CD302‐deficient mice."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, loss‐of‐function studies in embryonic carcinoma and embryonic stem cells have revealed that CD302 contributes to proper cardiomyogenesis by influencing early cardiac transcription factor expression, thereby linking this receptor to cardiac cell differentiation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Beyond its roles in normal development, CD302 is emerging as an attractive marker and therapeutic target in oncologic settings. For example, high surface expression on acute myeloid leukemia blasts and leukemic stem cells has been successfully exploited by antibody‐dependent cell cytotoxicity and internalization approaches, suggesting potential for targeted therapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, altered trafficking of CD302 via modulation of endocytic pathways has uncovered its enrichment as a tumor marker in certain contexts"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and differential expression profiles of CD302 have proven useful in the diagnostic stratification of neuroendocrine tumor metastases, aiding in distinguishing the primary site between pancreatic and ileal origins."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight the versatile functions of CD302—and by extension, potentially its coordinated activity with LY75—in modulating immune cell migration, antigen uptake, and presentation as well as influencing cellular differentiation and cancer biology. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tsun-Ho Lo, Pablo A Silveira, Phillip D Fromm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.1600259"}], "href": "https://doi.org/10.4049/jimmunol.1600259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27316686"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27316686"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Satoshi Yasuda, Tetsuya Hasegawa, Tetsuji Hosono, et al. "}, {"type": "b", "children": [{"type": "t", "text": "AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20110520"}], "href": "https://doi.org/10.1042/BJ20110520"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21554246"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21554246"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tsun-Ho Lo, Edward Abadir, Robin E Gasiorowski, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Examination of CD302 as a potential therapeutic target for acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0216368"}], "href": "https://doi.org/10.1371/journal.pone.0216368"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31075107"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31075107"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "David Tobys, Lisa Maria Kowalski, Eva Cziudaj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of clathrin-mediated endocytosis by knockdown of AP-2 leads to alterations in the plasma membrane proteome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Traffic (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/tra.12770"}], "href": "https://doi.org/10.1111/tra.12770"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33225555"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33225555"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "D Kaemmerer, N Posorski, F von Eggeling, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The search for the primary tumor in metastasized gastroenteropancreatic neuroendocrine neoplasm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Metastasis (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10585-014-9672-3"}], "href": "https://doi.org/10.1007/s10585-014-9672-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25098566"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25098566"}]}]}]}