{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLYN, a Src‐family tyrosine kinase, plays a pivotal role in hematologic malignancies by supporting cell survival and proliferation and mediating resistance to targeted therapies. In chronic myelogenous leukemia and related disorders, LYN is frequently overexpressed and activated even when BCR‐ABL kinase activity is dampened by inhibitors such as imatinib or nilotinib. In these contexts, LYN forms part of alternative signaling complexes—with partners including Gab2, c‐Cbl, and STAT5—and is sustained by upstream effectors like Jak2, thereby enabling leukemic cells to bypass BCR‐ABL dependence. Moreover, in acute myeloid leukemia and virus‐induced lymphomas, aberrant LYN activation and its interaction with mutated receptors such as FLT3/ITD contribute directly to autonomous cell growth and resistance to therapy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn solid tumors and other receptor‐mediated settings, LYN is a crucial modulator of invasive and metastatic behavior. Elevated LYN expression has been identified as a top-ranked gene in epithelial–mesenchymal transition signatures in breast cancer, where its activity promotes cell migration and invasion. In addition, studies have demonstrated that proper LYN trafficking from the Golgi to the plasma membrane—regulated by its palmitoylation state and conformational changes—and its association with lipid raft proteins are essential for its function. For instance, LYN’s interaction with the proline-rich region of platelet receptors such as GPVI and its role in LPA-induced IL-8 secretion highlight its contribution to receptor signaling and subcellular compartmentalization. In breast cancer cells, reduced LYN levels impair the expression of metastasis-associated markers like Claudin-2, while direct interactions between LYN and glycolipids such as lactosylceramide further modulate neutrophil responses."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "16"}, {"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in oncogenesis, LYN is integral to immune cell signaling and the regulation of cell trafficking and apoptosis. In B lymphocytes, aberrant LYN expression or subcellular mislocalization is associated with autoimmune disorders such as systemic lupus erythematosus, where genetic studies link variations in LYN with altered disease susceptibility. In monocytes, macrophages, and neutrophils, LYN modulates cytokine responses by engaging with inositol phosphatases like SHIP-1 and receptor phosphatases such as SHP-1, thereby influencing adhesion, migration, and the initiation of apoptotic cascades (e.g., via caspase-8 phosphorylation). Furthermore, LYN contributes to integrin-mediated adhesion and is essential for the proper balance between chemokine-dependent migration and cellular retention in hematopoietic niches."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "29"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nicholas J Donato, Ji Yuan Wu, Jonathan Stapley, et al. "}, {"type": "b", "children": [{"type": "t", "text": "BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.V101.2.690"}], "href": "https://doi.org/10.1182/blood.V101.2.690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12509383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12509383"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ji Wu, Feng Meng, Ling-Yuan Kong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Natl Cancer Inst (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/jnci/djn188"}], "href": "https://doi.org/10.1093/jnci/djn188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18577747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18577747"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "A K Samanta, S N Chakraborty, Y Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.7"}], "href": "https://doi.org/10.1038/onc.2009.7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19234487"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19234487"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ji Wu, Feng Meng, Henry Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-08-109330"}], "href": "https://doi.org/10.1182/blood-2007-08-109330"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18235045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18235045"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Cedric Dos Santos, Tinisha McDonald, Yin Wei Ho, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2012-11-466425"}], "href": "https://doi.org/10.1182/blood-2012-11-466425"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23896410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23896410"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Romain Gioia, Cédric Leroy, Claire Drullion, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2010-10-313692"}], "href": "https://doi.org/10.1182/blood-2010-10-313692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21730355"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21730355"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Om Prakash, O Rama Swamy, Xiochang Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-07-2781"}], "href": "https://doi.org/10.1182/blood-2004-07-2781"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15665117"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15665117"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "M Okamoto, F Hayakawa, Y Miyata, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lyn is an important component of the signal transduction pathway specific to FLT3/ITD and can be a therapeutic target in the treatment of AML with FLT3/ITD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.leu.2404547"}], "href": "https://doi.org/10.1038/sj.leu.2404547"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17230226"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17230226"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yong Guo, Qingqing Shan, Yuping Gong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biol Ther (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/cbt.21460"}], "href": "https://doi.org/10.4161/cbt.21460"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22895079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22895079"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Izumi Sato, Yuuki Obata, Kousuke Kasahara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential trafficking of Src, Lyn, Yes and Fyn is specified by the state of palmitoylation in the SH4 domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.034843"}], "href": "https://doi.org/10.1242/jcs.034843"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19258394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19258394"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Katsue Suzuki-Inoue, David Tulasne, Yang Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201012200"}], "href": "https://doi.org/10.1074/jbc.M201012200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11943772"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11943772"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yoon-La Choi, Melanie Bocanegra, Mi Jeong Kwon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3141"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3141"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20215510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20215510"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Yutong Zhao, Donghong He, Bahman Saatian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of lysophosphatidic acid-induced epidermal growth factor receptor transactivation and interleukin-8 secretion in human bronchial epithelial cells by protein kinase Cdelta, Lyn kinase, and matrix metalloproteinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M511224200"}], "href": "https://doi.org/10.1074/jbc.M511224200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16687414"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16687414"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Sanae Ben Mkaddem, Amaya Murua, Héloise Flament, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lyn and Fyn function as molecular switches that control immunoreceptors to direct homeostasis or inflammation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-017-00294-0"}], "href": "https://doi.org/10.1038/s41467-017-00294-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28811476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28811476"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "M Iida, T M Brand, D A Campbell, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Yes and Lyn play a role in nuclear translocation of the epidermal growth factor receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.90"}], "href": "https://doi.org/10.1038/onc.2012.90"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22430206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22430206"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Elena Chiricozzi, Maria Grazia Ciampa, Giuseppina Brasile, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct interaction, instrumental for signaling processes, between LacCer and Lyn in the lipid rafts of neutrophil-like cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Lipid Res (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1194/jlr.M055319"}], "href": "https://doi.org/10.1194/jlr.M055319"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25418321"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25418321"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Fabian Flores-Borja, Panagiotis S Kabouridis, Elizabeth C Jury, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased Lyn expression and translocation to lipid raft signaling domains in B lymphocytes from patients with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.21416"}], "href": "https://doi.org/10.1002/art.21416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16320343"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16320343"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Christopher P Baran, Susheela Tridandapani, Cheryl D Helgason, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The inositol 5'-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M305021200"}], "href": "https://doi.org/10.1074/jbc.M305021200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12882960"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12882960"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "R Lu, G S Vidal, J A Kelly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic associations of LYN with systemic lupus erythematosus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/gene.2009.19"}], "href": "https://doi.org/10.1038/gene.2009.19"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19369946"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19369946"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Yu Liu, Jie Dong, Rong Mu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-30a promotes B cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arthritis Rheum (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/art.37912"}], "href": "https://doi.org/10.1002/art.37912"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23450709"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23450709"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Song Hui Jia, Jean Parodo, Andras Kapus, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706462200"}], "href": "https://doi.org/10.1074/jbc.M706462200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18086677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18086677"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Hideaki Ishikawa, Naohiro Tsuyama, Saeid Abroun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirements of src family kinase activity associated with CD45 for myeloma cell proliferation by interleukin-6."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood.v99.6.2172"}], "href": "https://doi.org/10.1182/blood.v99.6.2172"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11877294"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11877294"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Karim Kaabeche, Jérome Lemonnier, Sandrine Le Mée, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M402469200"}], "href": "https://doi.org/10.1074/jbc.M402469200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15190072"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15190072"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Kousuke Kasahara, Yuji Nakayama, Kikuko Ikeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trafficking of Lyn through the Golgi caveolin involves the charged residues on alphaE and alphaI helices in the kinase domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.200403011"}], "href": "https://doi.org/10.1083/jcb.200403011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15173188"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15173188"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Lucia De Franceschi, Carlo Tomelleri, Alessandro Matte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2011-05-355339"}], "href": "https://doi.org/10.1182/blood-2011-05-355339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21951684"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21951684"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Eric I Zimmerman, Claudia M Dollins, Melissa Crawford, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lyn kinase-dependent regulation of miR181 and myeloid cell leukemia-1 expression: implications for drug resistance in myelogenous leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Pharmacol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/mol.110.066258"}], "href": "https://doi.org/10.1124/mol.110.066258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20693279"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20693279"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Shibichakravarthy Kannan, Aaron Audet, Jessica Knittel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Src kinase Lyn is crucial for Pseudomonas aeruginosa internalization into lung cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Immunol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/eji.200635973"}], "href": "https://doi.org/10.1002/eji.200635973"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16791881"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16791881"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Phuong-Hien Nguyen, Oleg Fedorchenko, Natascha Rosen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccell.2016.09.007"}], "href": "https://doi.org/10.1016/j.ccell.2016.09.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27728807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27728807"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "Jingyan Han, Guoying Zhang, Emily J Welch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A critical role for Lyn kinase in strengthening endothelial integrity and barrier function."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2013-03-491423"}], "href": "https://doi.org/10.1182/blood-2013-03-491423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24108461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24108461"}]}]}]}