MAGEA2B Gene

Name	melanoma antigen family A2B
Description	This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMembers of the MAGE‐A subfamily—exemplified by MAGEA2—play a critical role in modulating the cellular response to stress through interference with p53‐dependent tumor suppressor pathways. For instance, MAGEA2 forms complexes with wild‐type p53 and recruits histone deacetylase 3 (HDAC3), which in turn strongly down‐regulates p53 transactivation activity. In addition, MAGEA2 disrupts p53 acetylation at PML nuclear bodies and, by associating with MDM2, it inhibits the E3 ubiquitin ligase activity that normally degrades key regulators such as MDM4, thereby stabilizing this potent p53 inhibitor."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nNotably, high levels of MAGEA2 expression have been linked to chemoresistance and poor clinical outcomes in various cancers. In breast cancer models, MAGEA2 not only confers resistance to agents such as etoposide and tamoxifen by attenuating p53‐dependent apoptosis, but also enhances estrogen receptor (ER)–dependent signaling. Similarly, in lung tumors, elevated MAGEA2 expression is associated with impaired p53 responses and correlates with adverse patient prognosis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in p53 modulation, MAGEA2 is implicated in the tumorigenesis of several other cancers. In head and neck squamous cell carcinoma, its expression has been examined in relation to tumor progression, while in prostate cancer as well as in testicular germ cell tumors, MAGEA2 has been shown to promote proliferation and survival, contributing to malignant progression and chemoresistance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nComplementing these functional attributes, the expression of MAGEA2 is tightly regulated at the epigenetic level. Studies have demonstrated that promoter hypermethylation—mediated by methyl-CpG binding proteins such as MBD1—can repress MAGE-A gene transcription in non-malignant contexts, whereas loss of such methylation contributes to its aberrant activation in tumor cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Martin Monte, Marta Simonatto, Leticia Y Peche, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0510834103"}], "href": "https://doi.org/10.1073/pnas.0510834103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16847267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16847267"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "L Y Peche, M Scolz, M F Ladelfa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MageA2 restrains cellular senescence by targeting the function of PMLIV/p53 axis at the PML-NBs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2011.173"}], "href": "https://doi.org/10.1038/cdd.2011.173"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22117195"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22117195"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lynnette Marcar, Bianca Ihrig, John Hourihan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0127713"}], "href": "https://doi.org/10.1371/journal.pone.0127713"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26001071"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26001071"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "P-P Wong, C C Yeoh, A S Ahmad, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of MAGEA antigens as causal players in the development of tamoxifen-resistant breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2014.45"}], "href": "https://doi.org/10.1038/onc.2014.45"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24662835"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24662835"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Hideki Ujiie, Tatsuya Kato, Daiyoon Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of MAGEA2 has a prognostic significance and is a potential therapeutic target for patients with lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2017.3984"}], "href": "https://doi.org/10.3892/ijo.2017.3984"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28498455"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28498455"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Jutta Ries, Eleftherios Vairaktaris, Nur Mollaoglu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of melanoma-associated antigens in oral squamous cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Oral Pathol Med (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1600-0714.2007.00600.x"}], "href": "https://doi.org/10.1111/j.1600-0714.2007.00600.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18197853"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18197853"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Chad A Glazer, Ian M Smith, Sheetal Bhan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of MAGEA2 in head and neck cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Otolaryngol Head Neck Surg (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1001/archoto.2011.2"}], "href": "https://doi.org/10.1001/archoto.2011.2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21422315"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21422315"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Azadeh Khalvandi, Maryam Abolhasani, Zahra Madjd, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reduced cytoplasmic expression of MAGE-A2 predicts tumor aggressiveness and survival: an immunohistochemical analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Urol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00345-020-03395-6"}], "href": "https://doi.org/10.1007/s00345-020-03395-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32772147"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32772147"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Leili Saeednejad Zanjani, Mahdieh Razmi, Fahimeh Fattahi, et al. 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"}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "hMAGEA2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Accelerates the Progression of Prostate Cancer "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the EFNA3-Erk1/2 Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21873/anticanres.17097"}], "href": "https://doi.org/10.21873/anticanres.17097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38925815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38925815"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Frank Wischnewski, Olaf Friese, Klaus Pantel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-06-0364"}], "href": "https://doi.org/10.1158/1541-7786.MCR-06-0364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17634428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17634428"}]}]}]}
Synonyms	MAGE2
NCBI Gene ID	266740
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAGEA2B has 1,046 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 34 datasets.

Click the + buttons to view associations for MAGEA2B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAGEA2B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAGEA2B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MAGEA2B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MAGEA2B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAGEA2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAGEA2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAGEA2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CTD Gene-Disease Associations	diseases associated with MAGEA2B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAGEA2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAGEA2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAGEA2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAGEA2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAGEA2B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MAGEA2B from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MAGEA2B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAGEA2B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
	GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations	transcription factor perturbations changing expression of MAGEA2B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Viral Infections	virus perturbations changing expression of MAGEA2B gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset.
	GTEx Tissue Gene Expression Profiles 2023	tissues with high or low expression of MAGEA2B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset.
	HPA Cell Line Gene Expression Profiles	cell lines with high or low expression of MAGEA2B gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset.
	InterPro Predicted Protein Domain Annotations	protein domains predicted for MAGEA2B protein from the InterPro Predicted Protein Domain Annotations dataset.
	JASPAR Predicted Human Transcription Factor Targets 2025	transcription factors regulating expression of MAGEA2B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset.
	JASPAR Predicted Transcription Factor Targets	transcription factors regulating expression of MAGEA2B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.
	Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAGEA2B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
	KnockTF Gene Expression Profiles with Transcription Factor Perturbations	transcription factor perturbations changing expression of MAGEA2B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset.
	MiRTarBase microRNA Targets	microRNAs targeting MAGEA2B gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset.
	NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles	drug perturbations changing expression of MAGEA2B gene from the NIBR DRUG-seq U2OS MoA Box dataset.
	PFOCR Pathway Figure Associations 2024	pathways involving MAGEA2B protein from the Wikipathways PFOCR 2024 dataset.
	Rummagene Transcription Factor Associations 2026	transcription factors regulating expression of MAGEA2B gene from the Rummagene Transcription Factor Associations 2026 dataset.
	RummaGEO Drug Perturbation Signatures	drug perturbations changing expression of MAGEA2B gene from the RummaGEO Drug Perturbation Signatures dataset.
	RummaGEO Gene Perturbation Signatures	gene perturbations changing expression of MAGEA2B gene from the RummaGEO Gene Perturbation Signatures dataset.
	TargetScan Predicted Nonconserved microRNA Targets	microRNAs regulating expression of MAGEA2B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores	tissues with high expression of MAGEA2B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.
	TISSUES Curated Tissue Protein Expression Evidence Scores 2025	tissues with high expression of MAGEA2B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset.
	TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025	tissues co-occuring with MAGEA2B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset.