| Name | melanoma antigen family B10 |
| Description | This gene encodes a member of the B subfamily of the melanoma associated antigen protein family. The encoded protein is specifically expressed in testis and tumor cells. [provided by RefSeq, Apr 2010] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Members of the melanoma antigen (MAGE) family, normally expressed in the male germline but aberrantly activated in various cancers, have been shown to contribute to tumorigenesis by reprogramming key regulatory pathways. Although most functional studies have focused on MAGE‐A3/6 and MAGE‐A4 – which promote cancer cell viability by triggering ubiquitin‐mediated degradation of tumor‐suppressive proteins such as AMPKα1 and by stabilizing factors that facilitate trans‐lesion DNA synthesis (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "– expression profiling in sarcoma has identified a subset of MAGE family members, including MAGEB10, as being significantly overexpressed (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Comparative analyses of positive selection and tissue‐specific expression patterns further indicate that cancer/testis antigens may impact key processes such as apoptosis, spermatogenesis, and genomic stability (see"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", while genomic studies in both human and canine models of cancer highlight disrupted regulatory networks in which these genes may participate (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In this context, MAGEB10 appears to be part of a broader oncogenic program wherein the reactivation of cancer/testis antigens may facilitate the suppression of normal cellular checkpoints and promote tumor progression. Its overexpression in sarcoma, together with other functionally related MAGE members, supports a model in which these genes contribute to oncogenesis—possibly by modulating ubiquitin signaling, altering energy homeostasis, and impacting DNA damage responses. Collectively, these findings suggest that MAGEB10 and its related family members are promising candidates for further investigation as biomarkers and therapeutic targets in cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carlos T Pineda, Saumya Ramanathan, Klementina Fon Tacer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Degradation of AMPK by a cancer-specific ubiquitin ligase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2015.01.034"}], "href": "https://doi.org/10.1016/j.cell.2015.01.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25679763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25679763"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M Greenwalt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms12105"}], "href": "https://doi.org/10.1038/ncomms12105"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27377895"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27377895"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Pan Cai, Yan Lu, Zhifeng Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Trophinin Is an Important Biomarker and Prognostic Factor in Osteosarcoma: Data Mining from Oncomine and the Cancer Genome Atlas Databases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/6885897"}], "href": "https://doi.org/10.1155/2021/6885897"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34307667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34307667"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Rasmus Nielsen, Carlos Bustamante, Andrew G Clark, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A scan for positively selected genes in the genomes of humans and chimpanzees."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pbio.0030170"}], "href": "https://doi.org/10.1371/journal.pbio.0030170"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15869325"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15869325"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "David Brocks, Christopher R Schmidt, Michael Daskalakis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ng.3889"}], "href": "https://doi.org/10.1038/ng.3889"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28604729"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28604729"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Magali Naville, Minaka Ishibashi, Marco Ferg, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms7904"}], "href": "https://doi.org/10.1038/ncomms7904"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25908307"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25908307"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Malin Melin, Patricio Rivera, Maja Arendt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Analysis Identifies Germ-Line Risk Factors Associated with Canine Mammary Tumours."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1006029"}], "href": "https://doi.org/10.1371/journal.pgen.1006029"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27158822"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27158822"}]}]}]}
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| Proteins | MAGBA_HUMAN |
| NCBI Gene ID | 139422 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MAGEB10 has 1,208 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 46 datasets.
Click the + buttons to view associations for MAGEB10 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MAGEB10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MAGEB10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAGEB10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with MAGEB10 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAGEB10 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MAGEB10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MAGEB10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of MAGEB10 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MAGEB10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAGEB10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with MAGEB10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by MAGEB10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MAGEB10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MAGEB10 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAGEB10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MAGEB10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MAGEB10 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MAGEB10 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MAGEB10 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving MAGEB10 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving MAGEB10 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing MAGEB10 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing MAGEB10 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MAGEB10 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MAGEB10 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MAGEB10 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MAGEB10 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of MAGEB10 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of MAGEB10 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for MAGEB10 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of MAGEB10 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MAGEB10 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAGEB10 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MAGEB10 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MAGEB10 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| NURSA Protein Complexes | protein complexs containing MAGEB10 protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for MAGEB10 from the Pathway Commons Protein-Protein Interactions dataset. | |
| Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles | cell types and tissues with high or low DNA methylation of MAGEB10 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of MAGEB10 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MAGEB10 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MAGEB10 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MAGEB10 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MAGEB10 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MAGEB10 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MAGEB10 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MAGEB10 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
