MAGI3 Gene

HGNC Family	Membrane-associated guanylate kinases
Name	membrane associated guanylate kinase, WW and PDZ domain containing 3
Description	Predicted to enable frizzled binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within positive regulation of JUN kinase activity. Located in cell junction. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n MAGI3 is a multidomain, PDZ‐domain–containing scaffold protein that plays diverse roles in cell signaling and adhesion. In the setting of non‐canonical Wnt/planar cell polarity signaling, MAGI3 helps assemble receptor complexes—including Frizzled and Van Gogh homologs together with PTEN and adhesion molecules—to maintain tissue polarity and regulate cell movement."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In several virus‐associated malignancies, high‐risk human papillomavirus (HPV) E6 proteins have been shown to target MAGI3 (along with related MAGI family members) for proteasome‐mediated degradation via specific PDZ interactions, an event that may contribute to the loss of tumor‐suppressive functions in infected cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Genetic studies have also implicated MAGI3 in the regulation of immune and endocrine functions. Variants in MAGI3 have been associated with altered thyroid peroxidase antibody levels and an increased risk of autoimmune thyroid disease, as well as being linked to rheumatoid arthritis susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of influenza A virus infection, the NS1 protein’s conserved PDZ‐binding motif enables interactions with a range of PDZ proteins including MAGI3. Such interactions are associated with mislocalization of tight junction components and disruption of epithelial barrier function."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In neural tissues, MAGI3 has been shown to interact with synaptic receptors such as brain‐specific angiogenesis inhibitor‐1 (BAI1), thereby modulating downstream signaling cascades (e.g., ERK phosphorylation) that are important for synaptic organization and receptor signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n As a scaffold at the plasma membrane, MAGI3 also participates in the regulation of dephosphorylation events by bridging receptor protein tyrosine phosphatases (e.g., RPTPβ) with their substrates, thereby contributing to the control of cell–cell and cell–matrix interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In colon cancer cells, MAGI3 interacts directly with the lysophosphatidic acid receptor LPA(2) via its PDZ domains. This interaction modulates G‐protein coupling, influencing signaling through pathways such as ERK and RhoA to ultimately inhibit cell migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Alterations in MAGI3 levels have also been associated with cervical cancer progression, with evidence suggesting that reduced MAGI3 expression may promote pro‐apoptotic pathways in cervical carcinoma cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Notably, an aberrant premature cleavage and polyadenylation event in the MAGI3 transcript generates a truncated isoform—MAGI3(pPA)—that acts in a dominant‐negative fashion. This truncated protein fails to interact properly with the YAP oncoprotein, thereby relieving YAP inhibition and promoting malignant transformation in breast epithelial cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genome‐wide association studies have linked specific single nucleotide polymorphisms in MAGI3 to an increased risk of inflammatory bowel disease, suggesting that altered expression of MAGI3 may affect intestinal epithelial barrier integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in glioma, decreased MAGI3 expression correlates with reduced PTEN levels, enhanced Akt phosphorylation, and more aggressive tumor growth, underscoring a tumor‐suppressive role for MAGI3 in brain cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight MAGI3 as a critical scaffold protein at the crossroads of cell polarity, adhesion, and growth factor signaling whose dysregulation—whether via genetic variation, viral targeting, or aberrant mRNA processing—can contribute to the pathogenesis of a broad spectrum of diseases including cancer and autoimmune disorders.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Masaru Katoh "}, {"type": "b", "children": [{"type": "t", "text": "WNT/PCP signaling pathway and human cancer (review)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2005)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16273260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16273260"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Miranda Thomas, Richard Laura, Karin Hepner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1205668"}], "href": "https://doi.org/10.1038/sj.onc.1205668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12140759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12140759"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Daliborka Lazić, Martin Hufbauer, Paola Zigrino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human papillomavirus type 8 E6 oncoprotein inhibits transcription of the PDZ protein syntenin-2."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.00132-12"}], "href": "https://doi.org/10.1128/JVI.00132-12"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22623796"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22623796"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Marco Medici, Eleonora Porcu, Giorgio Pistis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pgen.1004123"}], "href": "https://doi.org/10.1371/journal.pgen.1004123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24586183"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24586183"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S Steer, V Abkevich, A Gutin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Immun (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.gene.6364359"}], "href": "https://doi.org/10.1038/sj.gene.6364359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17159887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17159887"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lisa Golebiewski, Hongbing Liu, Ronald T Javier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.05070-11"}], "href": "https://doi.org/10.1128/JVI.05070-11"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21849460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21849460"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Hongbing Liu, Lisa Golebiewski, Eugene C Dow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01278-10"}], "href": "https://doi.org/10.1128/JVI.01278-10"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20702615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20702615"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jason R Stephenson, Kevin J Paavola, Stacy A Schaefer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M113.489757"}], "href": "https://doi.org/10.1074/jbc.M113.489757"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23782696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23782696"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Konstantin Adamsky, Katya Arnold, Helena Sabanay, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.00302"}], "href": "https://doi.org/10.1242/jcs.00302"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12615970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12615970"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Sei-Jung Lee, Stefanie L Ritter, Huanchun Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2010.11.054"}], "href": "https://doi.org/10.1053/j.gastro.2010.11.054"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21134377"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21134377"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Huanchun Zhang, Dongsheng Wang, Hong Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGI-3 regulates LPA-induced activation of Erk and RhoA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2006.06.008"}], "href": "https://doi.org/10.1016/j.cellsig.2006.06.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16904289"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16904289"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Keiichiro Nakamura, Fernando Abarzua, Atsushi Hongo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The role of hepatocyte growth factor activator inhibitor-1 (HAI-1) as a prognostic indicator in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2009)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19578736"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19578736"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Thomas K Ni, Jessica S Elman, Dexter X Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Premature polyadenylation of MAGI3 is associated with diminished N"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "-methyladenosine in its large internal exon."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-19916-8"}], "href": "https://doi.org/10.1038/s41598-018-19916-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29362392"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29362392"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Elisabeth Norén, Marie-Rose Mellander, Sven Almer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Variation and Gene Expression Levels of Tight Junction Genes Indicates Relationships Between PTEN as well as MAGI1 and Microscopic Colitis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dig Dis Sci (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10620-017-4857-7"}], "href": "https://doi.org/10.1007/s10620-017-4857-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29204743"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29204743"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Qian Ma, Yan Zhang, Ran Meng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Environ Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3967/bes2015.072"}], "href": "https://doi.org/10.3967/bes2015.072"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26248734"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26248734"}]}]}]}
Synonyms	MAGI-3, DJ730K3.2
Proteins	MAGI3_HUMAN
NCBI Gene ID	260425
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAGI3 has 6,141 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 111 datasets.

Click the + buttons to view associations for MAGI3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAGI3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAGI3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAGI3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAGI3 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAGI3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAGI3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAGI3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAGI3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAGI3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAGI3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAGI3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAGI3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAGI3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAGI3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAGI3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAGI3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAGI3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAGI3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAGI3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAGI3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAGI3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAGI3 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAGI3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MAGI3 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAGI3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAGI3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MAGI3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MAGI3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAGI3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAGI3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAGI3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAGI3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAGI3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAGI3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MAGI3 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MAGI3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MAGI3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MAGI3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MAGI3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MAGI3 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAGI3 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.