MAN2C1 Gene

Name	mannosidase, alpha, class 2C, member 1
Description	Predicted to enable alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Located in nucleoplasm. Implicated in congenital disorder of deglycosylation 2. [provided by Alliance of Genome Resources, Mar 2025]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Accumulating evidence indicates that MAN2C1, a cytosolic α‐mannosidase, plays multifaceted roles in both glycan processing and cell signaling that contribute to diverse pathological states. Epigenetic regulation of MAN2C1 (via altered methylation levels) has been linked to modified stress responses and an increased risk of post‐traumatic stress disorder, suggesting that changes in its expression may moderate the impact of cumulative traumatic events."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, MAN2C1 has been shown to directly interact with the tumor suppressor PTEN, impairing its PIP(3) phosphatase activity and consequently activating AKT signaling, which promotes prostate cancer progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in signal transduction, MAN2C1 is critical for the breakdown of free oligosaccharides generated during protein N‐glycosylation. Disruption of its expression or activity leads to the accumulation of aberrant mannosylated oligosaccharides and impaired glycoprotein processing, thereby perturbing endoplasmic reticulum homeostasis and upregulating ER‐associated degradation pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In cultured cancer cells, knockdown of MAN2C1 induces mitochondria‐dependent and CHOP‐associated apoptosis as well as mitotic arrest with microtubule disorganization, effects observed in both HeLa cells and esophageal carcinoma models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Interestingly, reduced MAN2C1 expression in immune cell models has been implicated in enhanced cell adhesion—through upregulation of adhesion molecules such as CD54 and LFA‐1—suggesting additional roles in modulating immune cell interactions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, in nasopharyngeal carcinoma cells, attenuation of MAN2C1 correlates with decreased malignancy, whereas transgenic overexpression in mouse models leads to enhanced tumor growth, invasion, and metastasis, likely via alterations in N‐glycosylation processes that affect both cellular adhesion and immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, clinical observations further broaden the functional profile of MAN2C1: population‐based studies have correlated its expression levels with cognitive performance, while imaging strategies exploiting α‐mannosidase 2C1 activity have demonstrated its overexpression in breast tumors, highlighting its potential utility as both a biomarker and diagnostic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In summary, MAN2C1 exhibits pleiotropic functions that span from its canonical role in glycan catabolism to non‐enzymatic regulation of cell signaling and adhesion. These multifaceted activities underscore its involvement in stress responses, oncogenesis, and cellular homeostasis, thereby making it a promising target for further investigation in both biomedical research and clinical applications.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Monica Uddin, Sandro Galea, Shun-Chiao Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gene expression and methylation signatures of MAN2C1 are associated with PTSD."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dis Markers (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/DMA-2011-0750"}], "href": "https://doi.org/10.3233/DMA-2011-0750"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21508515"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21508515"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Lizhi He, Catherine Fan, Anil Kapoor, et al. "}, {"type": "b", "children": [{"type": "t", "text": "α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms1309"}], "href": "https://doi.org/10.1038/ncomms1309"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21556061"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21556061"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Coralie Bernon, Yoann Carré, Elina Kuokkanen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Glycobiology (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/glycob/cwq169"}], "href": "https://doi.org/10.1093/glycob/cwq169"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20978011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20978011"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Silvia Paciotti, Emanuele Persichetti, Katharina Klein, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Accumulation of free oligosaccharides and tissue damage in cytosolic α-mannosidase (Man2c1)-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.550509"}], "href": "https://doi.org/10.1074/jbc.M114.550509"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24550399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24550399"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Li Wang, Tadashi Suzuki "}, {"type": "b", "children": [{"type": "t", "text": "Dual functions for cytosolic α-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its α-mannosidase activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.425702"}], "href": "https://doi.org/10.1074/jbc.M112.425702"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23486476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23486476"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yun Tian, Ji Yu Ju, Yi Qun Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/j.1349-7006.2008.01019.x"}], "href": "https://doi.org/10.1111/j.1349-7006.2008.01019.x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19018777"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19018777"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Li Qu, Ji Yu Ju, Shuang Ling Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of the alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.cr.7310065"}], "href": "https://doi.org/10.1038/sj.cr.7310065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16721356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16721356"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Y Shi, Y Tian, Y Q Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of malignant activities of nasopharyngeal carcinoma cells with high expression of CD44 by siRNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2007)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17611662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17611662"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Z G Xiang, D D Jiang, Y Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "hMan2c1 transgene promotes tumor progress in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transgenic Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11248-009-9299-3"}], "href": "https://doi.org/10.1007/s11248-009-9299-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19572206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19572206"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Alejandro Cáceres, Tõnu Esko, Irene Pappa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0157739"}], "href": "https://doi.org/10.1371/journal.pone.0157739"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27355585"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27355585"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Kyohhei Fujita, Mako Kamiya, Takafusa Yoshioka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "ACS Cent Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acscentsci.0c01189"}], "href": "https://doi.org/10.1021/acscentsci.0c01189"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33376783"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33376783"}]}]}]}
Synonyms	MAN6A8, MANA, MANA1
Proteins	MA2C1_HUMAN
NCBI Gene ID	4123
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAN2C1 has 6,392 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, disease, phenotype or trait, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 106 datasets.

Click the + buttons to view associations for MAN2C1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAN2C1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAN2C1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAN2C1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAN2C1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAN2C1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAN2C1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAN2C1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MAN2C1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAN2C1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAN2C1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAN2C1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAN2C1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAN2C1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAN2C1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAN2C1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAN2C1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAN2C1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAN2C1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MAN2C1 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAN2C1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MAN2C1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAN2C1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAN2C1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAN2C1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAN2C1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAN2C1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAN2C1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAN2C1 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAN2C1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAN2C1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAN2C1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAN2C1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAN2C1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAN2C1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAN2C1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAN2C1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MAN2C1 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MAN2C1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MAN2C1 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MAN2C1 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MAN2C1 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.