MAP1B Gene

HGNC Family	Protein phosphatase 1 regulatory subunits (PPP1R)
Name	microtubule-associated protein 1B
Description	This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Microtubule‐associated protein 1B (MAP1B) is emerging as a key regulator of neuronal microtubule dynamics. In neurons, MAP1B associates with microtubules to promote their assembly and to fine‐tune microtubule stability and organization—processes that are critical for axonal and dendritic extension, growth cone motility, and synapse formation. Its function is tightly regulated by phosphorylation: in developing neurons, c‐Jun N‐terminal kinase (JNK1)–mediated phosphorylation of MAP1B is necessary for optimal microtubule binding and assembly, whereas glycogen synthase kinase‐3β (GSK‐3β) phosphorylates MAP1B at defined residues that act as a molecular switch to control microtubule dynamics in growth cones."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Furthermore, MAP1B levels are subject to translational control. Fragile X mental retardation protein (FMRP) represses the translation of MAP1B during active synaptogenesis, ensuring that MAP1B protein levels decline appropriately. When FMRP function is lost—as in Fragile X syndrome—the resulting misregulated, elevated MAP1B expression leads to abnormally increased microtubule stability and disrupted synaptic development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In parallel, studies in Drosophila have demonstrated that the MAP1B homolog Futsch is regulated by RNA-binding proteins such as TDP-43, linking proper mRNA localization and translation at neuromuscular junctions to axonal microtubule and synaptic stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Additionally, interactions between MAP1B and proteins like DAPK-1 as well as its regulated degradation by the ubiquitin machinery (mediated, for instance, by gigaxonin) further integrate MAP1B into pathways governing autophagy, membrane dynamics, and neuronal survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings emphasize that MAP1B is a critical cytoskeletal modulator whose precise regulation via phosphorylation and translational control is essential for proper neuronal development and plasticity. Misregulation of MAP1B may contribute to neurodevelopmental and neurodegenerative disorders by disrupting microtubule dynamics and, consequently, neuronal connectivity.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lufen Chang, Ying Jones, Mark H Ellisman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s1534-5807(03)00094-7"}], "href": "https://doi.org/10.1016/s1534-5807(03"}, {"type": "t", "text": "00094-7) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12689591"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12689591"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Niraj Trivedi, Phil Marsh, Robert G Goold, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.01697"}], "href": "https://doi.org/10.1242/jcs.01697"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15731007"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15731007"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Robert Lu, Houping Wang, Zhe Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The fragile X protein controls microtubule-associated protein 1B translation and microtubule stability in brain neuron development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0404995101"}], "href": "https://doi.org/10.1073/pnas.0404995101"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15475576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15475576"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "L Chen, S W Yun, J Seto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The fragile X mental retardation protein binds and regulates a novel class of mRNAs containing U rich target sequences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0306-4522(03)00406-8"}], "href": "https://doi.org/10.1016/s0306-4522(03"}, {"type": "t", "text": "00406-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12927206"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12927206"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Alyssa N Coyne, Bhavani Bagevalu Siddegowda, Patricia S Estes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.2526-14.2014"}], "href": "https://doi.org/10.1523/JNEUROSCI.2526-14.2014"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25429138"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25429138"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ben Harrison, Michaela Kraus, Lindsay Burch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M706040200"}], "href": "https://doi.org/10.1074/jbc.M706040200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18195017"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18195017"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Elizabeth Allen, Jianqing Ding, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature04256"}], "href": "https://doi.org/10.1038/nature04256"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16227972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16227972"}]}]}]}
Synonyms	FUTSCH, MAP5, PPP1R102
Proteins	MAP1B_HUMAN
NCBI Gene ID	4131
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAP1B has 13,085 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 134 datasets.

Click the + buttons to view associations for MAP1B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAP1B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAP1B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAP1B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAP1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAP1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAP1B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAP1B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAP1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAP1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAP1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAP1B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAP1B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAP1B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAP1B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAP1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAP1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAP1B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAP1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAP1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MAP1B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MAP1B protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAP1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAP1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAP1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAP1B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAP1B gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MAP1B gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAP1B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAP1B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MAP1B gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MAP1B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MAP1B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAP1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAP1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAP1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAP1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAP1B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAP1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAP1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAP1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MAP1B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.