MAP3K7 Gene

HGNC Family	Mitogen-activated protein kinase cascade
Name	mitogen-activated protein kinase kinase kinase 7
Description	The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n MAP3K7, also known as TAK1, is a pivotal serine/threonine kinase that acts as a central signaling node integrating multiple extracellular cues into well‐orchestrated intracellular responses. It is activated downstream of a variety of receptors—including those for interleukin‐1, tumor necrosis factor, Toll‐like receptors, and transforming growth factor–β—and in turn it triggers key downstream effectors such as the IκB kinase complex (IKK), nuclear factor–κB (NF‐κB), and the mitogen‐activated protein kinases (MAPKs) JNK and p38 (see."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Activation of MAP3K7 is tightly regulated through its interaction with adaptor proteins (such as TABs) and is modulated by ubiquitin signals—for instance, through TRAF6-mediated K63-linked ubiquitination and the assembly of free polyubiquitin chains—which promote its autophosphorylation and catalytic activity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In immune and inflammatory contexts, MAP3K7 is essential for proper cytokine signaling and cell survival. Its function is critical in B cells and macrophages where it mediates responses to pathogen‐associated and danger signals; deficiencies in TAK1 lead to impaired NF‐κB and MAPK activation, compromised cytokine production, and increased cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " In diffuse large B-cell lymphoma, for example, somatic mutations affecting MAP3K7—even if occurring alongside mutations in other upstream regulators—contribute to prolonged NF‐κB activation and thus support lymphomagenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n MAP3K7 also operates at the interface of inflammatory and metabolic signaling. In cardiac and hepatic systems, TAK1 is required not only to relay stress and cytokine signals but also to engage metabolic regulators such as AMP-activated protein kinase (AMPK), thereby safeguarding cellular energy homeostasis and preventing pathological remodeling like fibrosis and hepatocarcinogenesis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "13"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cancer, MAP3K7 is emerging as a target of interest. Its activity sustains signaling pathways—such as hyperactivated Wnt-dependent transcription in KRAS-dependent colon cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "and TGF–β-induced NF‐κB activation in head and neck squamous cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": "—that promote tumor cell survival, invasion, and metastasis. Moreover, negative regulation of MAP3K7 activity by deubiquitinating enzymes (e.g., CYLD) underscores its importance as a molecular hub whose dysregulation can trigger persistent inflammatory and pro-oncogenic signals."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Additional studies have highlighted the role of TAK1 in mediating apoptotic responses through the modulation of stress kinase pathways"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": "and in the regulation of inflammasome homeostasis to prevent spontaneous cell death."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": " Beyond these signaling contexts, MAP3K7 has been identified as a component of larger chromatin-modifying complexes that link extracellular stimuli to transcriptional regulation and cell fate decisions"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", further emphasizing its multifaceted role in cellular physiology.\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, this body of evidence establishes MAP3K7/TAK1 as a central regulator of inflammation, immunity, metabolism, and carcinogenesis, making it an attractive target for therapeutic intervention in a range of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Mara Compagno, Wei Keat Lim, Adina Grunn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature07968"}], "href": "https://doi.org/10.1038/nature07968"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19412164"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19412164"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shintaro Sato, Hideki Sanjo, Kiyoshi Takeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Essential function for the kinase TAK1 in innate and adaptive immune responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni1255"}], "href": "https://doi.org/10.1038/ni1255"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16186825"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16186825"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jae-Hyuck Shim, Changchun Xiao, Amber E Paschal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.1360605"}], "href": "https://doi.org/10.1101/gad.1360605"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16260493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16260493"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hiroaki Sakurai, Shunsuke Suzuki, Noritaka Kawasaki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M301598200"}], "href": "https://doi.org/10.1074/jbc.M301598200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12842894"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12842894"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Thomas Pertel, Stéphane Hausmann, Damien Morger, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRIM5 is an innate immune sensor for the retrovirus capsid lattice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature09976"}], "href": "https://doi.org/10.1038/nature09976"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21512573"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21512573"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zong-Ping Xia, Lijun Sun, Xiang Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Direct activation of protein kinases by unanchored polyubiquitin chains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nature (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nature08247"}], "href": "https://doi.org/10.1038/nature08247"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19675569"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19675569"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Fei Huang, Cheng-Yuan Kao, Shinichiro Wachi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Requirement for both JAK-mediated PI3K signaling and ACT1/TRAF6/TAK1-dependent NF-kappaB activation by IL-17A in enhancing cytokine expression in human airway epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.179.10.6504"}], "href": "https://doi.org/10.4049/jimmunol.179.10.6504"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17982039"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17982039"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kira Bettermann, Mihael Vucur, Johannes Haybaeck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAK1 suppresses a NEMO-dependent but NF-kappaB-independent pathway to liver cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2010.03.021"}], "href": "https://doi.org/10.1016/j.ccr.2010.03.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20478530"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20478530"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "R K Subbarao Malireddi, Prajwal Gurung, Jayadev Mavuluri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20171922"}], "href": "https://doi.org/10.1084/jem.20171922"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29500178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29500178"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Min Xie, Dou Zhang, Jason R B Dyck, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0604708103"}], "href": "https://doi.org/10.1073/pnas.0604708103"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17085580"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17085580"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Norimichi Koitabashi, Thomas Danner, Ari L Zaiman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI44824"}], "href": "https://doi.org/10.1172/JCI44824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21537080"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21537080"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Sayaka Inokuchi, Tomonori Aoyama, Kouichi Miura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0909781107"}], "href": "https://doi.org/10.1073/pnas.0909781107"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20080763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20080763"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ling Yang, Yoon Seok Roh, Jingyi Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26698"}], "href": "https://doi.org/10.1002/hep.26698"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23996730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23996730"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Anurag Singh, Michael F Sweeney, Min Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2011.12.033"}], "href": "https://doi.org/10.1016/j.cell.2011.12.033"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22341439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22341439"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "C Freudlsperger, Y Bian, S Contag Wise, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2012.171"}], "href": "https://doi.org/10.1038/onc.2012.171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22641218"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22641218"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "William W Reiley, Wei Jin, Andrew Joon Lee, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Exp Med (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1084/jem.20062694"}], "href": "https://doi.org/10.1084/jem.20062694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17548520"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17548520"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sofia Edlund, Shizhong Bu, Norbert Schuster, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.02-03-0037"}], "href": "https://doi.org/10.1091/mbc.02-03-0037"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12589052"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12589052"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yuan-Liang Wang, Francesco Faiola, Muyu Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806936200"}], "href": "https://doi.org/10.1074/jbc.M806936200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18838386"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18838386"}]}]}]}
Synonyms	TAK1, MEKK7, FMD2, TGF1A, CSCF
Proteins	M3K7_HUMAN
NCBI Gene ID	6885
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAP3K7 has 9,011 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 143 datasets.

Click the + buttons to view associations for MAP3K7 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAP3K7 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MAP3K7 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAP3K7 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAP3K7 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAP3K7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAP3K7 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAP3K7 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MAP3K7 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAP3K7 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAP3K7 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAP3K7 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MAP3K7 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAP3K7 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAP3K7 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MAP3K7 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAP3K7 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAP3K7 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAP3K7 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAP3K7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAP3K7 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MAP3K7 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MAP3K7 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAP3K7 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAP3K7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAP3K7 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MAP3K7 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAP3K7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAP3K7 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MAP3K7 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAP3K7 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAP3K7 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAP3K7 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MAP3K7 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAP3K7 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate MAP3K7 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MAP3K7 gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MAP3K7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MAP3K7 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAP3K7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAP3K7 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAP3K7 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.