MAPK10 Gene

HGNC Family	Mitogen-activated protein kinase cascade
Name	mitogen-activated protein kinase 10
Description	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMAPK10, also known as JNK3, is a stress‐activated protein kinase predominantly expressed in neurons that plays a central role in transducing extracellular stress cues into intracellular responses. Structural and biochemical studies have revealed that MAPK10 is activated via a scaffolding mechanism mediated by arrestin proteins, which bind directly to the kinase and its upstream activators to ensure precise spatiotemporal control of its function in processes such as synaptic regulation and neuronal survival. These investigations have further defined distinct binding interfaces and conformational changes that underpin MAPK10 activation in response to neural stimuli."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pathological contexts, alterations in MAPK10 signaling have been linked to developmental and oncogenic disorders. Aberrant genetic rearrangements resulting in truncated MAPK10 proteins have been associated with intellectual disability and seizures, underscoring its importance in normal brain development. Moreover, dysregulation of MAPK10 expression in tumors is evident from studies demonstrating that its 3′‐UTR is directly targeted by miR‑27a‑3p, with reduced MAPK10 levels correlating with enhanced metastatic potential in certain carcinomas. In neuroblastoma, expression profiling has further identified MAPK10 as a hub gene with high connectivity within regulatory networks, indicating that subtle changes in its expression may contribute to tumorigenesis. Additionally, emerging data suggest a modifier role for MAPK10 in other neurodevelopmental disorders."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nTherapeutic strategies aimed at modulating MAPK10 activity continue to be explored owing to its dual role in neuronal survival and degeneration. Pharmacological approaches—including the design of novel, cell‐permeable peptides and small‐molecule inhibitors targeting its kinase activity—have demonstrated efficacy in attenuating harmful stress responses, such as cytokine‑induced apoptosis, thereby highlighting MAPK10 as a promising target in neuroprotective as well as anticancer interventions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiufeng Song, Sergio Coffa, Haian Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "How does arrestin assemble MAPKs into a signaling complex?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806124200"}], "href": "https://doi.org/10.1074/jbc.M806124200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19001375"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19001375"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "G Ramarao, Ck Waghmare, Nalini Srivastava, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regional alterations of JNK3 and CaMKIIα subunit expression in the rat brain after soman poisoning."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Exp Toxicol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/0960327110386814"}], "href": "https://doi.org/10.1177/0960327110386814"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21041242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21041242"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xanthi Antoniou, Mattia Falconi, Daniele Di Marino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK3 as a therapeutic target for neurodegenerative diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-2011-091567"}], "href": "https://doi.org/10.3233/JAD-2011-091567"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21321401"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21321401"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "John D Laughlin, Jerome C Nwachukwu, Mariana Figuera-Losada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural mechanisms of allostery and autoinhibition in JNK family kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Structure (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.str.2012.09.021"}], "href": "https://doi.org/10.1016/j.str.2012.09.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23142346"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23142346"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xuanzhi Zhan, Alejandro Perez, Luis E Gimenez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Arrestin-3 binds the MAP kinase JNK3α2 via multiple sites on both domains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2014.01.001"}], "href": "https://doi.org/10.1016/j.cellsig.2014.01.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24412749"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24412749"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Clara Alice Musi, Graziella Agrò, Francesco Santarella, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK3 as Therapeutic Target and Biomarker in Neurodegenerative and Neurodevelopmental Brain Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells9102190"}], "href": "https://doi.org/10.3390/cells9102190"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32998477"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32998477"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Stella-Amrei Kunde, Nils Rademacher, Andreas Tzschach, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterisation of de novo MAPK10/JNK3 truncation mutations associated with cognitive disorders in two unrelated patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00439-012-1260-5"}], "href": "https://doi.org/10.1007/s00439-012-1260-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23329067"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23329067"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sarah Gourmaud, Claire Paquet, Julien Dumurgier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Psychiatry Neurosci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1503/jpn.140062"}], "href": "https://doi.org/10.1503/jpn.140062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25455349"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25455349"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Lihua Li, Zhaohui Luo "}, {"type": "b", "children": [{"type": "t", "text": "Dysregulated miR-27a-3p promotes nasopharyngeal carcinoma cell proliferation and migration by targeting Mapk10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/or.2017.5544"}], "href": "https://doi.org/10.3892/or.2017.5544"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28393229"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28393229"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Jiangtao Liu, Yulin Li "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of MAPK10, TUBB2B and RASL11B may contribute to the development of neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2019.10589"}], "href": "https://doi.org/10.3892/mmr.2019.10589"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31432180"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31432180"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yang Wang, Qian Jiang, Aravinda Chakravarti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-4516-mediated regulation of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MAPK10"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " relies on 3' UTR "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "cis"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-acting variants and contributes to the altered risk of Hirschsprung disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jmedgenet-2019-106615"}], "href": "https://doi.org/10.1136/jmedgenet-2019-106615"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32066630"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32066630"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hélène Ezanno, Valérie Pawlowski, Saida Abdelli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK3 is required for the cytoprotective effect of exendin 4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Diabetes Res (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2014/814854"}], "href": "https://doi.org/10.1155/2014/814854"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25025079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25025079"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Ravi Kumar Rajan, M Ramanathan "}, {"type": "b", "children": [{"type": "t", "text": "Identification and neuroprotective evaluation of a potential c-Jun N-terminal kinase 3 inhibitor through structure-based virtual screening and in-vitro assay."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Comput Aided Mol Des (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10822-020-00297-y"}], "href": "https://doi.org/10.1007/s10822-020-00297-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32040807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32040807"}]}]}]}
Synonyms	P54BSAPK, JNK3, JNK3A, SAPK1B, PRKM10, P493F12
Proteins	MK10_HUMAN
NCBI Gene ID	5602
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAPK10 has 6,055 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 130 datasets.

Click the + buttons to view associations for MAPK10 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAPK10 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK10 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK10 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAPK10 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAPK10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAPK10 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK10 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MAPK10 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK10 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAPK10 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAPK10 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MAPK10 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAPK10 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK10 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MAPK10 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAPK10 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAPK10 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK10 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAPK10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAPK10 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MAPK10 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MAPK10 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAPK10 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAPK10 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAPK10 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	CORUM Protein Complexes	protein complexs containing MAPK10 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAPK10 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAPK10 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAPK10 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAPK10 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MAPK10 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAPK10 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DEPOD Substrates of Phosphatases	phosphatases that dephosphorylate MAPK10 protein from the curated DEPOD Substrates of Phosphatases dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MAPK10 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAPK10 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAPK10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAPK10 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MAPK10 protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAPK10 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK10 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAPK10 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.