| HGNC Family | Mitogen-activated protein kinase cascade |
| Name | mitogen-activated protein kinase 8 |
| Description | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMAPK8, also known as c‐Jun N‐terminal kinase (JNK), acts as a master stress‐responsive kinase that coordinates the balance between prosurvival autophagy and programmed cell death. Under conditions of nutrient deprivation or chemical stress, MAPK8 phosphorylates anti‐apoptotic proteins such as Bcl‑2—thereby disrupting its binding to Beclin 1—to initiate autophagy, while prolonged or excessive activation drives apoptotic cascades through events such as Bid cleavage and mitochondrial cytochrome c release. In various cellular models, exposure to xenobiotics (for example, nanosilver or shikonin) provokes reactive oxygen species (ROS) generation that triggers MAPK8 activation, amplifying apoptotic signals."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these stress‐induced cell fate decisions, MAPK8 integrates diverse extracellular and inflammatory signals to modulate metabolic and proliferative responses. It is activated downstream of cytokines, TGF‑β and adipokines, thereby contributing to insulin resistance, liver fibrogenesis and even tumorigenesis in hepatocellular carcinoma, prostate and osteosarcoma. In innate immunity, MAPK8 amplifies ROS production and facilitates inflammasome assembly in macrophages and modulates chemokine expression in neutrophils. Furthermore, by liaising with key regulators of regeneration and growth—such as components of the Hippo pathway—MAPK8 influences tissue repair and oncogenic transformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "8", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition, MAPK8 modulates complex transcriptional and signaling networks that govern cell proliferation, differentiation and survival. It responds to upstream cues—such as those mediated by polycystin‑1 or oxidative stress via ASK1—to regulate the activity or localization of nuclear factors including SIRT1, Foxo1, Egr‑1 and even pro‐apoptotic mediators like Nur77. Through these interactions, MAPK8 influences the expression of critical cell cycle regulators (for example, p21 and c‑Myc), shapes apoptotic sensitivity (via interplay with proteins such as WOX1) and thereby contributes to processes as diverse as tissue regeneration, tumor invasion and the maintenance of senescent cell viability."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "37"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Vladimir L Gabai, Katsuhide Mabuchi, Dick D Mosser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hsp72 and stress kinase c-jun N-terminal kinase regulate the bid-dependent pathway in tumor necrosis factor-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.22.10.3415-3424.2002"}], "href": "https://doi.org/10.1128/MCB.22.10.3415-3424.2002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11971973"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11971973"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yibin Deng, Xiaoyang Ren, Lin Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A JNK-dependent pathway is required for TNFalpha-induced apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0092-8674(03)00757-8"}], "href": "https://doi.org/10.1016/s0092-8674(03"}, {"type": "t", "text": "00757-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14532003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14532003"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kelly Davison, Koren K Mann, Samuel Waxman, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2003-05-1412"}], "href": "https://doi.org/10.1182/blood-2003-05-1412"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14701702"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14701702"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yi-Hong Hsin, Chun-Feng Chen, Shing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Toxicol Lett (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.toxlet.2008.04.015"}], "href": "https://doi.org/10.1016/j.toxlet.2008.04.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18547751"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18547751"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yongjie Wei, Sophie Pattingre, Sangita Sinha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.06.001"}], "href": "https://doi.org/10.1016/j.molcel.2008.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18570871"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18570871"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xin Mao, Chun Rong Yu, Wen Hua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Res (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cr.2008.86"}], "href": "https://doi.org/10.1038/cr.2008.86"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18663379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18663379"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "D-D Li, L-L Wang, R Deng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.441"}], "href": "https://doi.org/10.1038/onc.2008.441"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19060920"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19060920"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Michiko Onuma, Jeffrey D Bub, Thomas L Rummel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prostate cancer cell-adipocyte interaction: leptin mediates androgen-independent prostate cancer cell proliferation through c-Jun NH2-terminal kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M304984200"}], "href": "https://doi.org/10.1074/jbc.M304984200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12902351"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12902351"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Patrick G Arndt, Naohito Suzuki, Natalie J Avdi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M309901200"}], "href": "https://doi.org/10.1074/jbc.M309901200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14699155"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14699155"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yasushi Shintani, Michael A Hollingsworth, Margaret J Wheelock, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Collagen I promotes metastasis in pancreatic cancer by activating c-Jun NH(2)-terminal kinase 1 and up-regulating N-cadherin expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-06-2322"}], "href": "https://doi.org/10.1158/0008-5472.CAN-06-2322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17178870"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17178870"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ivan Tattoli, Leticia A Carneiro, Muguette Jéhanno, et al. "}, {"type": "b", "children": [{"type": "t", "text": "NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7401161"}], "href": "https://doi.org/10.1038/sj.embor.7401161"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18219313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18219313"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Motozo Yamashita, Karoly Fatyol, Chaoyang Jin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molcel.2008.09.002"}], "href": "https://doi.org/10.1016/j.molcel.2008.09.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18922473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18922473"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Lijian Hui, Kurt Zatloukal, Harald Scheuch, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI37156"}], "href": "https://doi.org/10.1172/JCI37156"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19033664"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19033664"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Johannes Kluwe, Jean-Philippe Pradere, Geum-Youn Gwak, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Modulation of hepatic fibrosis by c-Jun-N-terminal kinase inhibition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2009.09.015"}], "href": "https://doi.org/10.1053/j.gastro.2009.09.015"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19782079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19782079"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Giovanni Solinas, Michael Karin "}, {"type": "b", "children": [{"type": "t", "text": "JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FASEB J (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1096/fj.09-151340"}], "href": "https://doi.org/10.1096/fj.09-151340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20371626"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20371626"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Dan Gao, Shanwei Nong, Xiuqing Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The effects of palmitate on hepatic insulin resistance are mediated by NADPH Oxidase 3-derived reactive oxygen species through JNK and p38MAPK pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M110.128694"}], "href": "https://doi.org/10.1074/jbc.M110.128694"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20647313"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20647313"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Jeremy W Chambers, Philip V LoGrasso "}, {"type": "b", "children": [{"type": "t", "text": "Mitochondrial c-Jun N-terminal kinase (JNK) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.223602"}], "href": "https://doi.org/10.1074/jbc.M111.223602"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21454558"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21454558"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Gongping Sun, Kenneth D Irvine "}, {"type": "b", "children": [{"type": "t", "text": "Ajuba family proteins link JNK to Hippo signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.2004324"}], "href": "https://doi.org/10.1126/scisignal.2004324"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24023255"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24023255"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Masahiro Okada, Atsushi Matsuzawa, Akihiko Yoshimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M114.579961"}], "href": "https://doi.org/10.1074/jbc.M114.579961"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25288801"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25288801"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Stephen C Parnell, Brenda S Magenheimer, Robin L Maser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201875200"}], "href": "https://doi.org/10.1074/jbc.M201875200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11912216"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11912216"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Geum-Yi Kim, Stephen E Mercer, Daina Z Ewton, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M201299200"}], "href": "https://doi.org/10.1074/jbc.M201299200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12058028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12058028"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Nan-Shan Chang, Joan Doherty, Amy Ensign "}, {"type": "b", "children": [{"type": "t", "text": "JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M208373200"}], "href": "https://doi.org/10.1074/jbc.M208373200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12514174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12514174"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Kiyotsugu Yoshida, Tomoko Yamaguchi, Tohru Natsume, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Cell Biol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncb1228"}], "href": "https://doi.org/10.1038/ncb1228"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15696159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15696159"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Alexandra Charruyer, Solène Grazide, Christine Bezombes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M412867200"}], "href": "https://doi.org/10.1074/jbc.M412867200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15769735"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15769735"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Murali Gururajan, Roger Chui, Anbu K Karuppannan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "c-Jun N-terminal kinase (JNK) is required for survival and proliferation of B-lymphoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2004-10-3819"}], "href": "https://doi.org/10.1182/blood-2004-10-3819"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15890690"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15890690"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Dan Kawamori, Hideaki Kaneto, Yoshihisa Nakatani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M508510200"}], "href": "https://doi.org/10.1074/jbc.M508510200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16282329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16282329"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Bing Han, Marco Mura, Cristiano F Andrade, et al. "}, {"type": "b", "children": [{"type": "t", "text": "TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.175.12.8303"}], "href": "https://doi.org/10.4049/jimmunol.175.12.8303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16339571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16339571"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Y-H Han, X Cao, B Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209358"}], "href": "https://doi.org/10.1038/sj.onc.1209358"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16434970"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16434970"}]}, {"type": "r", "ref": 29, "children": [{"type": "t", "text": "I-Ching Wang, Yi-Ju Chen, Douglas E Hughes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M709892200"}], "href": "https://doi.org/10.1074/jbc.M709892200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18524773"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18524773"}]}, {"type": "r", "ref": 30, "children": [{"type": "t", "text": "Olivia Fromigué, Zahia Hamidouche, Pierre J Marie "}, {"type": "b", "children": [{"type": "t", "text": "Blockade of the RhoA-JNK-c-Jun-MMP2 cascade by atorvastatin reduces osteosarcoma cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M801436200"}], "href": "https://doi.org/10.1074/jbc.M801436200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18757369"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18757369"}]}, {"type": "r", "ref": 31, "children": [{"type": "t", "text": "Nargis Nasrin, Virendar K Kaushik, Eric Fortier, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JNK1 phosphorylates SIRT1 and promotes its enzymatic activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0008414"}], "href": "https://doi.org/10.1371/journal.pone.0008414"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20027304"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20027304"}]}, {"type": "r", "ref": 32, "children": [{"type": "t", "text": "Alexandre Puissant, Guillaume Robert, Nina Fenouille, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-09-3537"}], "href": "https://doi.org/10.1158/0008-5472.CAN-09-3537"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20103647"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20103647"}]}, {"type": "r", "ref": 33, "children": [{"type": "t", "text": "Izortze Santin, Fabrice Moore, Maikel L Colli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic β-cell apoptosis via regulation of the BH3-only protein Bim."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Diabetes (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2337/db11-0758"}], "href": "https://doi.org/10.2337/db11-0758"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21984578"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21984578"}]}, {"type": "r", "ref": 34, "children": [{"type": "t", "text": "Archana Jha, Malini Ahuja, Sandip Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Convergent regulation of the lysosomal two-pore channel-2 by Mg²⁺, NAADP, PI(3,5)P₂ and multiple protein kinases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/embj.201387035"}], "href": "https://doi.org/10.1002/embj.201387035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24502975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24502975"}]}, {"type": "r", "ref": 35, "children": [{"type": "t", "text": "Valeria Iansante, Pui Man Choy, Sze Wai Fung, et al. "}, {"type": "b", "children": [{"type": "t", "text": "PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms8882"}], "href": "https://doi.org/10.1038/ncomms8882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26258887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26258887"}]}, {"type": "r", "ref": 36, "children": [{"type": "t", "text": "Hongyan Yang, Yan Xie, Dongyu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.15813"}], "href": "https://doi.org/10.18632/oncotarget.15813"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28445976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28445976"}]}, {"type": "r", "ref": 37, "children": [{"type": "t", "text": "Reut Yosef, Noam Pilpel, Nurit Papismadov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "p21 maintains senescent cell viability under persistent DNA damage response by restraining JNK and caspase signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO J (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.15252/embj.201695553"}], "href": "https://doi.org/10.15252/embj.201695553"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28607003"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28607003"}]}]}]}
|
| Synonyms | JNK1, JNK21B1/2, PRKM8, JNK, SAPK1, SAPK1C, JNK1A2, JNK-46 |
| Proteins | MK08_HUMAN |
| NCBI Gene ID | 5599 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
MAPK8 has 15,797 functional associations with biological entities spanning 9 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 127 datasets.
Click the + buttons to view associations for MAPK8 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MAPK8 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of MAPK8 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MAPK8 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MAPK8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq | tissue samples with high or low expression of MAPK8 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MAPK8 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| Biocarta Pathways | pathways involving MAPK8 protein from the Biocarta Pathways dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of MAPK8 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MAPK8 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MAPK8 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAPK8 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MAPK8 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CCLE Cell Line Gene Mutation Profiles | cell lines with MAPK8 gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset. | |
| CCLE Cell Line Proteomics | Cell lines associated with MAPK8 protein from the CCLE Cell Line Proteomics dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with MAPK8 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK8 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MAPK8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MAPK8 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MAPK8 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing MAPK8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing MAPK8 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with MAPK8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MAPK8 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAPK8 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with MAPK8 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Chemical Interactions | chemicals interacting with MAPK8 gene/protein from the curated CTD Gene-Chemical Interactions dataset. | |
| CTD Gene-Disease Associations | diseases associated with MAPK8 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DeepCoverMOA Drug Mechanisms of Action | small molecule perturbations with high or low expression of MAPK8 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by MAPK8 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DEPOD Substrates of Phosphatases | phosphatases that dephosphorylate MAPK8 protein from the curated DEPOD Substrates of Phosphatases dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with MAPK8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MAPK8 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with MAPK8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with MAPK8 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| DrugBank Drug Targets | interacting drugs for MAPK8 protein from the curated DrugBank Drug Targets dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MAPK8 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK8 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MAPK8 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MAPK8 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with MAPK8 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with MAPK8 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of MAPK8 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MAPK8 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MAPK8 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MAPK8 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MAPK8 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MAPK8 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MAPK8 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MAPK8 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MAPK8 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving MAPK8 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving MAPK8 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving MAPK8 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing MAPK8 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing MAPK8 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing MAPK8 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by MAPK8 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by MAPK8 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by MAPK8 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of MAPK8 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MAPK8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MAPK8 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MAPK8 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| Guide to Pharmacology Chemical Ligands of Receptors | ligands (chemical) binding MAPK8 receptor from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with MAPK8 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MAPK8 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MAPK8 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of MAPK8 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HMDB Metabolites of Enzymes | interacting metabolites for MAPK8 protein from the curated HMDB Metabolites of Enzymes dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of MAPK8 gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of MAPK8 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of MAPK8 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MAPK8 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for MAPK8 from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with MAPK8 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for MAPK8 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of MAPK8 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of MAPK8 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MAPK8 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEA Substrates of Kinases | kinases that phosphorylate MAPK8 protein from the curated KEA Substrates of Kinases dataset. | |
| KEGG Pathways | pathways involving MAPK8 protein from the KEGG Pathways dataset. | |
| Kinase Library Tyrosine Kinome Atlas | kinases that phosphorylate MAPK8 protein from the Kinase Library Tyrosine Kinome Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MAPK8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles | cell lines with high or low expression of MAPK8 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles | cell lines with MAPK8 gene mutations from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Mutation Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MAPK8 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of MAPK8 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing MAPK8 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MAPK8 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MAPK8 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting MAPK8 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MAPK8 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by MAPK8 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MAPK8 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles | drug perturbations changing expression of MAPK8 gene from the NIBR DRUG-seq U2OS MoA Box dataset. | |
| PANTHER Pathways | pathways involving MAPK8 protein from the PANTHER Pathways dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for MAPK8 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MAPK8 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of MAPK8 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving MAPK8 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving MAPK8 protein from the Wikipathways PFOCR 2024 dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with MAPK8 protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| PhosphoSitePlus Substrates of Kinases | kinases that phosphorylate MAPK8 protein from the curated PhosphoSitePlus Substrates of Kinases dataset. | |
| PID Pathways | pathways involving MAPK8 protein from the PID Pathways dataset. | |
| Reactome Pathways 2014 | pathways involving MAPK8 protein from the Reactome Pathways dataset. | |
| Reactome Pathways 2024 | pathways involving MAPK8 protein from the Reactome Pathways 2024 dataset. | |
| Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MAPK8 gene from the Replogle et al., Cell, 2022 K562 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MAPK8 gene from the Replogle et al., Cell, 2022 K562 Genome-wide Perturb-seq Gene Perturbation Signatures dataset. | |
| Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures | gene perturbations changing expression of MAPK8 gene from the Replogle et al., Cell, 2022 RPE1 Essential Perturb-seq Gene Perturbation Signatures dataset. | |
| Roadmap Epigenomics Cell and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MAPK8 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue Gene Expression Profiles dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MAPK8 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MAPK8 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MAPK8 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs | drug perturbations changing phosphorylation of MAPK8 protein from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset. | |
| SynGO Synaptic Gene Annotations | synaptic terms associated with MAPK8 gene from the SynGO Synaptic Gene Annotations dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of MAPK8 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of MAPK8 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MAPK8 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MAPK8 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of MAPK8 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MAPK8 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of MAPK8 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MAPK8 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with MAPK8 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MAPK8 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving MAPK8 protein from the Wikipathways Pathways 2014 dataset. | |
| WikiPathways Pathways 2024 | pathways involving MAPK8 protein from the WikiPathways Pathways 2024 dataset. | |
