MAPK8IP3 Gene

Name	mitogen-activated protein kinase 8 interacting protein 3
Description	The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMAPK8IP3, also known as JIP3 or JSAP1, functions as a dynamic scaffold protein orchestrating multiple MAPK signaling cascades in response to diverse cellular stresses. In non‐neuronal cells, MAPK8IP3 plays a pivotal role in recruiting and organizing key kinases such as ASK1, SEK1/MKK4/7, and JNK in response to oxidative stress, glucose deprivation, and ultraviolet B irradiation. Through phosphorylation‐dependent interactions, it coordinates crosstalk with other scaffolds (e.g., JIP1) and focal adhesion molecules such as FAK and p130(Cas) to modulate cell migration, apoptosis, and even macropinocytic endocytosis. In cardiac myocytes, for instance, MAPK8IP3-mediated activation of the JNK cascade contributes to signaling events during pathological hypertrophy, while in airway epithelial cells its proper function is critical for wound closure under mechanical strain."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn neurons, MAPK8IP3 serves as a critical microtubule motor adaptor facilitating the long‐distance transport of essential cargoes. It directly binds receptors such as TrkB to promote their anterograde transport via kinesin-1, while also engaging dynein-dynactin complexes to ensure retrograde trafficking of autophagosomes, lysosomes, and other endocytic organelles along axons. Structural studies have revealed that its N-terminal RH1-LZI tandem forms a high-affinity elongated dimer that not only recruits both kinesin and dynein motors but also interacts with additional partners including myosin 5a, thereby integrating multiple motor systems. Loss of MAPK8IP3 in diverse neuronal models—from human iPSC-derived neurons to invertebrate systems—results in disrupted axonal transport, aberrant accumulation of lysosomal and autolysosomal compartments, and perturbed organization of the axonal cytoskeleton; indeed, its function is fundamental for maintaining neuronal homeostasis and efficient synaptic connectivity."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nClinically, genetic alterations in MAPK8IP3 have been increasingly linked to neurodevelopmental and neurodegenerative disorders. De novo as well as autosomal recessive pathogenic variants in the gene have been associated with intellectual disability, cerebral atrophy, axonal pathology—including motor neuron degeneration—and epileptogenic phenotypes. Such findings underscore the essential role of MAPK8IP3-mediated axonal transport in neuronal development and survival, and highlight its importance as a molecular nexus whose dysfunction may contribute to a spectrum of neurological diseases."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "20", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hiroshi Matsuura, Hideki Nishitoh, Kohsuke Takeda, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M202004200"}], "href": "https://doi.org/10.1074/jbc.M202004200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12189133"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12189133"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Noriteru Morita, Kenji Iizuka, Takeshi Murakami, et al. "}, {"type": "b", "children": [{"type": "t", "text": "N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1023/b:mcbi.0000038218.09259.1c"}], "href": "https://doi.org/10.1023/b:mcbi.0000038218.09259.1c"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15532711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15532711"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jae J Song, Yong J Lee "}, {"type": "b", "children": [{"type": "t", "text": "Cross-talk between JIP3 and JIP1 during glucose deprivation: SEK1-JNK2 and Akt1 act as mediators."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M502318200"}], "href": "https://doi.org/10.1074/jbc.M502318200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15911620"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15911620"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Takahisa Takino, Mitsutoshi Nakada, Hisashi Miyamori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M505241200"}], "href": "https://doi.org/10.1074/jbc.M505241200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16141199"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16141199"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Pat P Ongusaha, Hank H Qi, Lakshmi Raj, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Signal (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/scisignal.1161938"}], "href": "https://doi.org/10.1126/scisignal.1161938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19036714"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19036714"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Leena P Desai, Steven R White, Christopher M Waters "}, {"type": "b", "children": [{"type": "t", "text": "Mechanical stretch decreases FAK phosphorylation and reduces cell migration through loss of JIP3-induced JNK phosphorylation in airway epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Physiol Lung Cell Mol Physiol (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1152/ajplung.00076.2009"}], "href": "https://doi.org/10.1152/ajplung.00076.2009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19574423"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19574423"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Leena P Desai, Steven R White, Christopher M Waters "}, {"type": "b", "children": [{"type": "t", "text": "Cyclic mechanical stretch decreases cell migration by inhibiting phosphatidylinositol 3-kinase- and focal adhesion kinase-mediated JNK1 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M109.084335"}], "href": "https://doi.org/10.1074/jbc.M109.084335"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20018857"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20018857"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qinghua Ma, Yuxiu Liu, Lianghua Chen "}, {"type": "b", "children": [{"type": "t", "text": "JIP3 deficiency attenuates cardiac hypertrophy by suppression of JNK pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2018.03.208"}], "href": "https://doi.org/10.1016/j.bbrc.2018.03.208"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29604277"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29604277"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "N M Rafiq, L L Lyons, S Gowrishankar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JIP3 links lysosome transport to regulation of multiple components of the axonal cytoskeleton."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Commun Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s42003-021-02945-x"}], "href": "https://doi.org/10.1038/s42003-021-02945-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35013510"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35013510"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Shu-Hong Huang, Shan Duan, Tao Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "JIP3 mediates TrkB axonal anterograde transport and enhances BDNF signaling by directly bridging TrkB with kinesin-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Neurosci (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1523/JNEUROSCI.0436-11.2011"}], "href": "https://doi.org/10.1523/JNEUROSCI.0436-11.2011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21775604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21775604"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Tokiharu Sato, Momoe Ishikawa, Toru Yoshihara, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2015.08.024"}], "href": "https://doi.org/10.1016/j.febslet.2015.08.024"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26320416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26320416"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Paola Llinas, Mélanie Chenon, T Quyen Nguyen, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Recurrent de novo MAPK8IP3 variants cause neurological phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Ann Neurol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ana.25481"}], "href": "https://doi.org/10.1002/ana.25481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30945334"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30945334"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Chad D Williamson, Julie G Donaldson "}, {"type": "b", "children": [{"type": "t", "text": "Arf6, JIP3, and dynein shape and mediate macropinocytosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E19-01-0022"}], "href": "https://doi.org/10.1091/mbc.E19-01-0022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30969891"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30969891"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Fernando Vilela, Christophe Velours, Mélanie Chenon, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Structural characterization of the RH1-LZI tandem of JIP3/4 highlights RH1 domains as a cytoskeletal motor-binding motif."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-52537-3"}], "href": "https://doi.org/10.1038/s41598-019-52537-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31690808"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31690808"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Swetha Gowrishankar, Lila Lyons, Nisha Mohd Rafiq, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Biol Cell (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1091/mbc.E20-06-0382"}], "href": "https://doi.org/10.1091/mbc.E20-06-0382"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33788575"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33788575"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Sydney E Cason, Peter J Carman, Claire Van Duyne, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1083/jcb.202010179"}], "href": "https://doi.org/10.1083/jcb.202010179"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34014261"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34014261"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Ricardo Celestino, José B Gama, Artur F Castro-Rodrigues, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Effects of JIP3 on epileptic seizures: Evidence from temporal lobe epilepsy patients, kainic-induced acute seizures and pentylenetetrazole-induced kindled seizures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuroscience (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neuroscience.2015.05.008"}], "href": "https://doi.org/10.1016/j.neuroscience.2015.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26002316"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26002316"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Konrad Platzer, Heinrich Sticht, Stacey L Edwards, et al. "}, {"type": "b", "children": [{"type": "t", "text": "De Novo Variants in MAPK8IP3 Cause Intellectual Disability with Variable Brain Anomalies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2018.12.008"}], "href": "https://doi.org/10.1016/j.ajhg.2018.12.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30612693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30612693"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Judit Kárteszi, Alban Ziegler, Mariann Tihanyi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Compound heterozygous variants in MAPK8IP3 were detected in severe congenital hypotonia mimicking lethal spinal muscular atrophy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.63340"}], "href": "https://doi.org/10.1002/ajmg.a.63340"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37462082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37462082"}]}]}]}
Synonyms	SYD2, JIP3, SYD, JIP-3, JSAP1
Proteins	JIP3_HUMAN
NCBI Gene ID	23162
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAPK8IP3 has 7,331 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 119 datasets.

Click the + buttons to view associations for MAPK8IP3 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAPK8IP3 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK8IP3 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK8IP3 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAPK8IP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAPK8IP3 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAPK8IP3 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK8IP3 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAPK8IP3 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAPK8IP3 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAPK8IP3 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK8IP3 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAPK8IP3 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAPK8IP3 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK8IP3 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAPK8IP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAPK8IP3 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAPK8IP3 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAPK8IP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAPK8IP3 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MAPK8IP3 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAPK8IP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAPK8IP3 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAPK8IP3 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAPK8IP3 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MAPK8IP3 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAPK8IP3 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAPK8IP3 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MAPK8IP3 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAPK8IP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAPK8IP3 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAPK8IP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAPK8IP3 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAPK8IP3 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAPK8IP3 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAPK8IP3 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAPK8IP3 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MAPK8IP3 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MAPK8IP3 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MAPK8IP3 from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MAPK8IP3 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MAPK8IP3 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.