MAT1A Gene

Name	methionine adenosyltransferase I, alpha
Description	This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMethionine adenosyltransferase 1A (MAT1A) is a liver‐specific enzyme that catalyzes the synthesis of S‑adenosylmethionine (SAM), the principal methyl donor required for one‐carbon metabolism and diverse methylation reactions. Its expression is regulated by hormonal cues such as thyroid hormone T₃ and by distinct epigenetic mechanisms, underscoring its essential role in hepatocyte proliferation, differentiation, and normal liver function."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "6"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDeregulation of MAT1A, including its down‐regulation and mutation, has been closely linked to liver pathologies. Reduced MAT1A expression is associated with hepatocellular carcinoma and cholestatic liver injury, often manifesting as a switch from MAT1A to the alternative isoform MAT2A in aggressive tumors. Inherited mutations in MAT1A lead to MAT I/III deficiencies that result in persistent hypermethioninemia—a disorder detected in neonatal screening—with clinical outcomes ranging from benign to severe neurological deficits. These observations highlight its prognostic significance in liver cancer and metabolic dysfunction."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its catalytic function, MAT1A serves as a tumor suppressor by sustaining intracellular SAM levels and thereby maintaining proper epigenetic marks. It interacts with key metabolic regulators—including glycine N‑methyltransferase (GNMT) and chaperone proteins such as 14‑3‑3—to modulate cell cycle regulators like cyclin D1 (CCND1) and to influence cell proliferation, invasion, and apoptotic pathways. Moreover, emerging evidence has expanded its relevance to non‐hepatic cancers such as non‑small cell lung cancer, suggesting that targeting the MAT1A‐regulated pathways holds promise for novel therapeutic interventions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sheng-Ming Wu, Ya-Hui Huang, Yi-Hsin Lu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Thyroid hormone receptor-mediated regulation of the methionine adenosyltransferase 1 gene is associated with cell invasion in hepatoma cell lines."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-010-0281-2"}], "href": "https://doi.org/10.1007/s00018-010-0281-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20146079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20146079"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chao-Qiang Lai, Laurence D Parnell, Aron M Troen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAT1A variants are associated with hypertension, stroke, and markers of DNA damage and are modulated by plasma vitamin B-6 and folate."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Clin Nutr (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3945/ajcn.2009.28923"}], "href": "https://doi.org/10.3945/ajcn.2009.28923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20335551"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20335551"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Joaquín Fernández-Irigoyen, Enrique Santamaría, Yin-Hsiu Chien, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Enzymatic activity of methionine adenosyltransferase variants identified in patients with persistent hypermethioninemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2010.07.009"}], "href": "https://doi.org/10.1016/j.ymgme.2010.07.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20675163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20675163"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Maria Lauda Tomasi, Tony W H Li, Mei Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Inhibition of human methionine adenosyltransferase 1A transcription by coding region methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.22875"}], "href": "https://doi.org/10.1002/jcp.22875"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21678410"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21678410"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Maddalena Frau, Maria L Tomasi, Maria M Simile, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of transcriptional and posttranscriptional regulation of methionine adenosyltransferases in liver cancer progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.25643"}], "href": "https://doi.org/10.1002/hep.25643"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22318685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22318685"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yuan Ji, Kendra K S Nordgren, Yubo Chai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.112.046953"}], "href": "https://doi.org/10.1124/dmd.112.046953"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22807109"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22807109"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Mahoko Furujo, Masako Kinoshita, Masayoshi Nagao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methionine adenosyltransferase I/III deficiency: neurological manifestations and relevance of S-adenosylmethionine."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2012.08.002"}], "href": "https://doi.org/10.1016/j.ymgme.2012.08.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22951388"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22951388"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Heping Yang, Michele E Cho, Tony W H Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Invest (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1172/JCI63861"}], "href": "https://doi.org/10.1172/JCI63861"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23241961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23241961"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Naeem Shafqat, Joao R C Muniz, Ewa S Pilka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20121580"}], "href": "https://doi.org/10.1042/BJ20121580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23425511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23425511"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Masayoshi Nagao, Toju Tanaka, Mahoko Furujo "}, {"type": "b", "children": [{"type": "t", "text": "Spectrum of mutations associated with methionine adenosyltransferase I/III deficiency among individuals identified during newborn screening in Japan."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Genet Metab (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ymgme.2013.10.013"}], "href": "https://doi.org/10.1016/j.ymgme.2013.10.013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24231718"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24231718"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Heping Yang, Ting Liu, Jiaohong Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulated methionine adenosyltransferase α1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans(‡)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.28541"}], "href": "https://doi.org/10.1002/hep.28541"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26969892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26969892"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Yun Sun, Dingyuan Ma, Yanyun Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Analysis of MAT1A gene mutations in a child affected with simple hypermethioninemia]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2017.01.023"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2017.01.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28186605"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28186605"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Jihyun An, Seong Kyun Na, Ju Hyun Shim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Histological expression of methionine adenosyl transferase (MAT) 2A as a post-surgical prognostic surrogate in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Surg Oncol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jso.24994"}], "href": "https://doi.org/10.1002/jso.24994"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29448301"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29448301"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Li Gong, Lingyan Zhu, Tianlun Yang "}, {"type": "b", "children": [{"type": "t", "text": "Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2020.01.062"}], "href": "https://doi.org/10.1016/j.bbrc.2020.01.062"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31982134"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31982134"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yuan Li, Liqing Lu, Jian Tu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.31196"}], "href": "https://doi.org/10.1002/hep.31196"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32080887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32080887"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Chunmei Lin, Quanzhi Zheng, Mengyi Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Newborn screening and variant analysis for methionine adenosyltransferase I/III deficiency]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Yi Xue Yi Chuan Xue Za Zhi (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.issn.1003-9406.2020.05.008"}], "href": "https://doi.org/10.3760/cma.j.issn.1003-9406.2020.05.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32335878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32335878"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Allison Bannick, Sara Chase, Alyson Miner, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methionine adenosyltransferase I/III deficiency: Long-term follow-up and treatment of 3 adult siblings."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2020.104076"}], "href": "https://doi.org/10.1016/j.ejmg.2020.104076"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32980525"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32980525"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Liqing Lu, Jing Zhang, Wei Fan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulated 14-3-3ζ and methionine adenosyltransferase α1 interplay promotes liver cancer tumorigenesis in mice and humans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01980-6"}], "href": "https://doi.org/10.1038/s41388-021-01980-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34349244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34349244"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Po-Ming Chen, Cheng-Hsueh Tsai, Chieh-Cheng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of Methionine Cycle Genes "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MAT1A"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " and "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "GNMT"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Enriches Protein-Associated Translation Process and Worsens Hepatocellular Carcinoma Prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23010481"}], "href": "https://doi.org/10.3390/ijms23010481"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35008908"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35008908"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Lucía Barbier-Torres, Ben Murray, Jin Won Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Depletion of mitochondrial methionine adenosyltransferase α1 triggers mitochondrial dysfunction in alcohol-associated liver disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-022-28201-2"}], "href": "https://doi.org/10.1038/s41467-022-28201-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35091576"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35091576"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Wei Fan, DuoYao Cao, Bing Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Hepatic prohibitin 1 and methionine adenosyltransferase α1 defend against primary and secondary liver cancer metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hepatol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jhep.2023.11.022"}], "href": "https://doi.org/10.1016/j.jhep.2023.11.022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38086446"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38086446"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Shengping Shen, Ruili Liu, Jiazheng Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAT1A activation of glycolysis to promote NSCLC progression depends on stabilizing CCND1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-024-07113-7"}], "href": "https://doi.org/10.1038/s41419-024-07113-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39438468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39438468"}]}]}]}
Synonyms	MATA1, SAMS1
Proteins	METK1_HUMAN
NCBI Gene ID	4143
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAT1A has 5,040 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 117 datasets.

Click the + buttons to view associations for MAT1A from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAT1A Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MAT1A gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAT1A gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAT1A gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAT1A gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAT1A gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAT1A gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAT1A gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAT1A gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAT1A gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAT1A gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAT1A protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAT1A gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAT1A gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAT1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAT1A gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MAT1A gene from the curated ClinVar Gene-Phenotype Associations dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAT1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAT1A protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAT1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAT1A protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAT1A gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAT1A gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAT1A gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAT1A gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAT1A protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAT1A gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MAT1A gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MAT1A gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAT1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAT1A gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAT1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAT1A gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MAT1A protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAT1A gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAT1A gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAT1A gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAT1A from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MAT1A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MAT1A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MAT1A gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.