MAT2B Gene

HGNC Family	Short chain dehydrogenase/reductase superfamily (SDR)
Name	methionine adenosyltransferase II, beta
Description	The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMAT2B is the regulatory subunit of methionine adenosyltransferase‐2A (MAT2A), which catalyzes the formation of S‐adenosylmethionine (SAMe), the principal methyl donor in cellular methylation reactions. Structural and molecular characterization revealed that MAT2B exists as two major splice variants, V1 and V2, and crystallographic studies demonstrate that its core resembles a short‐chain dehydrogenase/reductase endowed with an extended domain that may provide unique ligand‐ and protein–binding properties. Moreover, kinetic studies indicate that MAT2B, through its physical association with MAT2A, modulates enzymatic efficiency and stability, while phosphorylation events during cellular activation further stabilize the MAT2A–MAT2B complex."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nIn a variety of cancer models, MAT2B has emerged as a pivotal promoter of cell growth and survival. In hepatocellular carcinoma cell lines, leptin stimulates the expression of MAT2B – along with MAT2A – to support a mitogenic response; conversely, RNA interference–mediated silencing of MAT2B in hepatoma and leukemic cells shifts enzymatic kinetics, reduces SAMe pools, and triggers apoptotic cell death. Co‐expression studies further reveal that MAT2B collaborates with MAT2A to enhance enzyme activity by reducing protein degradation. In addition, MAT2B interacts directly with GIT1, thereby facilitating the recruitment and activation of key components of the MEK/ERK signaling cascade, which leads to elevated cyclin D1 expression and accelerated tumor growth. Elevated levels of MAT2B have been documented in melanoma, osteosarcoma, and metastatic liver cancer models, where its ablation curtails proliferation, diminishes EGFR‐pathway signaling, and reduces markers of aggressiveness."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "12"}]}, {"type": "t", "text": ""}, {"type": "p", "children": [{"type": "t", "text": "\nEmerging evidence also implicates MAT2B in additional pathophysiological contexts. A common genetic variant upstream of MAT2B has been associated with chronic pain syndromes, hinting at its broader influence on neuroimmune interactions. Furthermore, a long non‐coding RNA designated lncMat2B has been identified in three‐dimensional tumor spheroids of breast cancer, where its expression is induced under severe hypoxia and contributes to tumor‐initiating properties as well as chemoresistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}]}]}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Heping Yang, Ainhoa Iglesias Ara, Nathaniel Magilnick, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastroenterology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1053/j.gastro.2007.10.027"}], "href": "https://doi.org/10.1053/j.gastro.2007.10.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18045590"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18045590"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Naeem Shafqat, Joao R C Muniz, Ewa S Pilka, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Insight into S-adenosylmethionine biosynthesis from the crystal structures of the human methionine adenosyltransferase catalytic and regulatory subunits."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20121580"}], "href": "https://doi.org/10.1042/BJ20121580"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23425511"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23425511"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Komal Ramani, Shant Donoyan, Maria Lauda Tomasi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of methionine adenosyltransferase α2 and β phosphorylation and stabilization in human hepatic stellate cell trans-differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24839"}], "href": "https://doi.org/10.1002/jcp.24839"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25294683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25294683"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jiraporn Panmanee, Jack Bradley-Clarke, Jose M Mato, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS J (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/febs.14790"}], "href": "https://doi.org/10.1111/febs.14790"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30776190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30776190"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Komal Ramani, Heping Yang, Meng Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Leptin's mitogenic effect in human liver cancer cells requires induction of both methionine adenosyltransferase 2A and 2beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.22064"}], "href": "https://doi.org/10.1002/hep.22064"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18041713"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18041713"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Qun Wang, Quan-Yan Liu, Zhi-Su Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocelluar carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "World J Gastroenterol (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3748/wjg.14.4633"}], "href": "https://doi.org/10.3748/wjg.14.4633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18698677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18698677"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Ramy R Attia, Lidia A Gardner, Engy Mahrous, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M804159200"}], "href": "https://doi.org/10.1074/jbc.M804159200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18753136"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18753136"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Kendra K S Nordgren, Yi Peng, Linda L Pelleymounter, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Drug Metab Dispos (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1124/dmd.111.040857"}], "href": "https://doi.org/10.1124/dmd.111.040857"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21813468"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21813468"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Hui Peng, Lily Dara, Tony W H Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26258"}], "href": "https://doi.org/10.1002/hep.26258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23325601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23325601"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yu Lei, Bo Zhang, Yaohua Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2016.3603"}], "href": "https://doi.org/10.3892/ijo.2016.3603"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27573889"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27573889"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yuan Yuan, Yonggang Wang, Zimei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAT2B promotes proliferation and inhibits apoptosis in osteosarcoma by targeting epidermal growth factor receptor and proliferating cell nuclear antigen."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4764"}], "href": "https://doi.org/10.3892/ijo.2019.4764"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30942439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30942439"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Lijun Wu, Ping Chen, Jun Ying, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Exp Med (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10238-019-00579-2"}], "href": "https://doi.org/10.1007/s10238-019-00579-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31493275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31493275"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Katerina Zorina-Lichtenwalter, Marc Parisien, Luda Diatchenko "}, {"type": "b", "children": [{"type": "t", "text": "Genetic studies of human neuropathic pain conditions: a review."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Pain (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/j.pain.0000000000001099"}], "href": "https://doi.org/10.1097/j.pain.0000000000001099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29240606"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29240606"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Alfredo García-Venzor, Edna Ayerim Mandujano-Tinoco, Araceli Ruiz-Silvestre, et al. "}, {"type": "b", "children": [{"type": "t", "text": "lncMat2B regulated by severe hypoxia induces cisplatin resistance by increasing DNA damage repair and tumor-initiating population in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgaa078"}], "href": "https://doi.org/10.1093/carcin/bgaa078"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32710610"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32710610"}]}]}]}
Synonyms	MAT-II, TGR, NBLA02999, MATIIBETA, SDR23E1
Proteins	MAT2B_HUMAN
NCBI Gene ID	27430
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MAT2B has 6,208 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 128 datasets.

Click the + buttons to view associations for MAT2B from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MAT2B Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MAT2B gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAT2B gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAT2B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MAT2B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MAT2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MAT2B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MAT2B gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MAT2B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAT2B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MAT2B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MAT2B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MAT2B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MAT2B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MAT2B protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MAT2B gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAT2B gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MAT2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MAT2B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MAT2B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MAT2B protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MAT2B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MAT2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MAT2B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MAT2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MAT2B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MAT2B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MAT2B gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MAT2B gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MAT2B protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MAT2B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MAT2B gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MAT2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MAT2B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MAT2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MAT2B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	DrugBank Drug Targets	interacting drugs for MAT2B protein from the curated DrugBank Drug Targets dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MAT2B gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MAT2B gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MAT2B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MAT2B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.