MATK Gene

HGNC Family	SH2 domain containing
Name	megakaryocyte-associated tyrosine kinase
Description	The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMATK, also known as CHK (Csk homologous kinase), is a nonreceptor tyrosine kinase that plays a pivotal role in modulating Src family kinase activity. Structural and binding studies have demonstrated that MATK/CHK contains a specialized SH2 domain and critical hydrophobic residues within its linker regions that govern its interactions with phosphorylated targets such as ErbB-2. These interactions are essential for its ability to inhibit Src-mediated signaling cascades in diverse cell types, including neural and epithelial cells, highlighting its importance in maintaining proper intracellular signaling balance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its canonical role as a Src inhibitor, MATK/CHK exerts multifaceted regulatory effects on cell proliferation and intracellular signal transduction. In neural and immune cells, MATK/CHK contributes to the formation of nuclear signaling complexes that enhance MAPK pathway activation independently of Src inhibition. For instance, MATK/CHK influences the phosphorylation status of key proteins during the late S phase and modulates the assembly of complexes such as SHP-2/Grb2 to promote Erk1/2 activation. In parallel, studies in mast cells and in IGF-I–responsive cells indicate that MATK-related kinase activity modulates growth factor receptor signaling and downstream substrate phosphorylation events, thereby influencing cell cycle progression and survival. Importantly, exogenous expression of MATK/CHK in neuroblastoma cells has been shown to suppress the CXCL12–CXCR4 autocrine loop, further underlining its role in controlling cell proliferation and homeostasis."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe tumor suppressor functions of MATK/CHK have emerged from studies in several human cancers. In colorectal cancer, reduced MATK/CHK expression—often via promoter hypermethylation—correlates with heightened Src kinase activity, enhanced anchorage-independent growth, and increased tumorigenesis. Similarly, loss of MATK/CHK expression in neuroblastoma leads to the upregulation of pro-survival signaling through the CXCL12–CXCR4 pathway. These observations underscore a critical role for MATK/CHK in restraining aberrant signaling that promotes uncontrolled cell proliferation and metastasis, thereby positioning MATK/CHK as a putative tumor suppressor in diverse clinical settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Soyoun Kim, Radoslaw Zagozdzon, Alan Meisler, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206018200"}], "href": "https://doi.org/10.1074/jbc.M206018200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12122014"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12122014"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Esa T Mikkola, Mathias Bergman "}, {"type": "b", "children": [{"type": "t", "text": "Conserved hydrophobicity in the SH2-kinase linker is required for catalytic activity of Csk and CHK."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/s0014-5793(03)00405-8"}], "href": "https://doi.org/10.1016/s0014-5793(03"}, {"type": "t", "text": "00405-8) PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12782282"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12782282"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sun-Ok Kim, Shalom Avraham, Shuxian Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.20442"}], "href": "https://doi.org/10.1002/cncr.20442"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15329911"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15329911"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yuji Nakayama, Naoto Yamaguchi "}, {"type": "b", "children": [{"type": "t", "text": "Multi-lobulation of the nucleus in prolonged S phase by nuclear expression of Chk tyrosine kinase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2004.11.027"}], "href": "https://doi.org/10.1016/j.yexcr.2004.11.027"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15748901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15748901"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Marina K Ayrapetov, Nguyen Hai Nam, Guofeng Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M504022200"}], "href": "https://doi.org/10.1074/jbc.M504022200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15890649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15890649"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Radoslaw Zagozdzon, Rafal Kaminski, Yigong Fu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Csk homologous kinase (CHK), unlike Csk, enhances MAPK activation via Ras-mediated signaling in a Src-independent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Signal (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cellsig.2005.07.016"}], "href": "https://doi.org/10.1016/j.cellsig.2005.07.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16168623"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16168623"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Byeong-Chel Lee, Shalom Avraham, Akira Imamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the nonreceptor tyrosine kinase MATK/CHK as an essential regulator of immune cells using Matk/CHK-deficient mice."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2005-12-4885"}], "href": "https://doi.org/10.1182/blood-2005-12-4885"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16574955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16574955"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Yuji Nakayama, Akiko Kawana, Asae Igarashi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Involvement of the N-terminal unique domain of Chk tyrosine kinase in Chk-induced tyrosine phosphorylation in the nucleus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2006.03.021"}], "href": "https://doi.org/10.1016/j.yexcr.2006.03.021"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16707123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16707123"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Marie-Pierre Belot, Latifa Abdennebi-Najar, Françoise Gaudin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.21357"}], "href": "https://doi.org/10.1002/jcb.21357"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17492661"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17492661"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Radoslaw Zagozdzon, Yigong Fu, Hava Karsenty Avraham "}, {"type": "b", "children": [{"type": "t", "text": "Csk homologous kinase inhibits CXCL12-CXCR4 signaling in neuroblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2008)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18292939"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18292939"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yashwanth Radhakrishnan, Xinchun Shen, Laura A Maile, et al. "}, {"type": "b", "children": [{"type": "t", "text": "IGF-I stimulates cooperative interaction between the IGF-I receptor and CSK homologous kinase that regulates SHPS-1 phosphorylation in vascular smooth muscle cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Endocrinol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1210/me.2011-0035"}], "href": "https://doi.org/10.1210/me.2011-0035"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21799000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21799000"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "S Zhu, J D Bjorge, H C Cheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Decreased CHK protein levels are associated with Src activation in colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1210838"}], "href": "https://doi.org/10.1038/sj.onc.1210838"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17934522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17934522"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anderly C Chüeh, Gahana Advani, Momeneh Foroutan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41388-021-01755-z"}], "href": "https://doi.org/10.1038/s41388-021-01755-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33767439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33767439"}]}]}]}
Synonyms	CTK, HYL, HHYLTK, HYLTK
Proteins	MATK_HUMAN
NCBI Gene ID	4145
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MATK has 5,844 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 112 datasets.

Click the + buttons to view associations for MATK from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MATK Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MATK gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MATK gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MATK gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MATK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MATK gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MATK gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MATK gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MATK gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MATK gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MATK gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MATK gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MATK gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MATK gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MATK gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MATK gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MATK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MATK gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MATK gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MATK protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MATK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MATK protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MATK gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MATK gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MATK gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MATK gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MATK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MATK gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MATK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MATK gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MATK gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MATK gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MATK gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MATK from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MATK gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MATK gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MATK from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MATK gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.
	GEO Signatures of Differentially Expressed Genes for Gene Perturbations	gene perturbations changing expression of MATK gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Kinase Perturbations	kinase perturbations changing expression of MATK gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
	GEO Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MATK gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.