{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMAZ, also known as SAF‐1 or Pur‐1, is a multifunctional C₂H₂‐type zinc finger transcription factor that plays critical roles in regulating both the initiation and termination phases of transcription as well as higher‐order genome organization. For example, MAZ contributes to RNA polymerase II pause‐dependent termination by binding GC‐rich pause elements and cooperates with classical insulator proteins—such as CTCF and components of the cohesin complex—to modulate large‐scale chromatin architecture and alternative splicing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn various cancers MAZ is frequently deregulated and its altered expression drives tumor progression. In glioblastoma, MAZ is directly targeted by miR‐449a such that its down‐regulation mediates tumor‐suppressive effects"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while in hepatocellular carcinoma increased MAZ levels correlate with enhanced epithelial–mesenchymal transition and metastatic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In pancreatic ductal adenocarcinoma MAZ stimulates invasive phenotypes via activation of CRAF–ERK signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "; in breast cancer, it drives tumor‐specific expression of nuclear receptors such as PPARγ1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", is involved in triple‐negative breast cancer through regulation of VEGF"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", and exerts a dual role by also suppressing aggressiveness in basal‐like subtypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, MAZ modulates colon cancer progression by enhancing oncogenic STAT3 signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", contributes to prostate cancer pathogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": ", and influences the integrity of the blood–tumor barrier."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": " In thyroid malignancies, aberrant MAZ activity—via effects on MAPK pathway effectors and direct up‐regulation of oncogenes—is linked to papillary thyroid carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "as well as other thyroid cancers"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", and single‐nucleotide variants affecting MAZ binding (as seen in HBV‐related HCC and via G‐quadruplex mechanisms) further highlight its oncogenic potential."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its role in cancer, MAZ is instrumental in normal developmental and physiological processes. It helps activate key promoters—for instance, stimulating transcription from the MYB promoter during cell cycle re‐entry"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "and regulating the parathyroid hormone/PTH‐related peptide receptor gene through a proximal binding site."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": " MAZ also forms complexes with other transcription factors (e.g. AP‐1) to synergistically drive genes such as MMP‐1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", and its overexpression can trigger cell cycle arrest via induction of p21."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " In the nervous system, MAZ participates in gliogenesis by promoting ADAM10 expression in response to cardiotrophin‐1"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": ", while proper eye development depends on MAZ‐mediated regulation of the Wnt/β‐catenin pathway (as evidenced by its disruption leading to ocular malformations, see below). Moreover, the existence of multiple alternatively transcribed isoforms—as revealed by differential promoter usage"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "—broadens the spectrum of MAZ’s regulatory repertoire, and its control over erythroid differentiation is underscored by its regulation of α‐globin expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMAZ is also a key mediator during inflammatory and immune responses. Its activity under chronic inflammatory conditions is linked to the regulation of cytokine‐responsive genes—for instance, direct modulation of the p53 promoter in response to Akt phosphorylation"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "—and altered splicing variants such as SAF‐2"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": "contribute to fine‐tuning of the inflammatory gene expression program. MAZ also participates in the induction of VEGF in arthritis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "25"}]}, {"type": "t", "text": "and is a target of autoantibodies in atherosclerosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "26"}]}, {"type": "t", "text": ", while associations with multiple sclerosis and cerebellar immune reactivity further underscore its involvement in immune disorders."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "27"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Natalia Gromak, Steven West, Nick J Proudfoot "}, {"type": "b", "children": [{"type": "t", "text": "Pause sites promote transcriptional termination of mammalian RNA polymerase II."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.26.10.3986-3996.2006"}], "href": "https://doi.org/10.1128/MCB.26.10.3986-3996.2006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16648491"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16648491"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Tiaojiang Xiao, Xin Li, Gary Felsenfeld "}, {"type": "b", "children": [{"type": "t", "text": "The Myc-associated zinc finger protein (MAZ) works together with CTCF to control cohesin positioning and genome organization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.2023127118"}], "href": "https://doi.org/10.1073/pnas.2023127118"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33558242"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33558242"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yilong Yao, Jun Ma, Yixue Xue, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2014.11.003"}], "href": "https://doi.org/10.1016/j.molonc.2014.11.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25487955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25487955"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Luo, Xiaonian Zhu, Wei Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MYC associated zinc finger protein promotes the invasion and metastasis of hepatocellular carcinoma by inducing epithelial mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.13416"}], "href": "https://doi.org/10.18632/oncotarget.13416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27861158"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27861158"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Gargi Maity, Inamul Haque, Arnab Ghosh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA117.000333"}], "href": "https://doi.org/10.1074/jbc.RA117.000333"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29414775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29414775"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Xin Wang, R Chase Southard, Clinton D Allred, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAZ drives tumor-specific expression of PPAR gamma 1 in breast cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Breast Cancer Res Treat (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10549-007-9765-7"}], "href": "https://doi.org/10.1007/s10549-007-9765-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17902047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17902047"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Alpana Ray, Bimal K Ray "}, {"type": "b", "children": [{"type": "t", "text": "Induction of Ras by SAF-1/MAZ through a feed-forward loop promotes angiogenesis in breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.362"}], "href": "https://doi.org/10.1002/cam4.362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25449683"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25449683"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Zi-Han Yu, Shu-Min Lun, Rui He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dual function of MAZ mediated by FOXF2 in basal-like breast cancer: Promotion of proliferation and suppression of progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2017.05.020"}], "href": "https://doi.org/10.1016/j.canlet.2017.05.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28577976"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28577976"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Daniel Triner, Cristina Castillo, Joe B Hakim, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00386-18"}], "href": "https://doi.org/10.1128/MCB.00386-18"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30181395"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30181395"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Li Jiao, Yun Li, Dan Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The prostate cancer-up-regulated Myc-associated zinc-finger protein (MAZ) modulates proliferation and metastasis through reciprocal regulation of androgen receptor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-013-0570-3"}], "href": "https://doi.org/10.1007/s12032-013-0570-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23609189"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23609189"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Lini Zhao, Ping Wang, Yunhui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-34c regulates the permeability of blood-tumor barrier via MAZ-mediated expression changes of ZO-1, occludin, and claudin-5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.24799"}], "href": "https://doi.org/10.1002/jcp.24799"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25201524"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25201524"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jiajia Zeng, Long Zhang, Linying Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAZ promotes thyroid cancer progression by driving transcriptional reprogram and enhancing ERK1/2 activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2024.217201"}], "href": "https://doi.org/10.1016/j.canlet.2024.217201"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39197582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39197582"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Chuanjun Zheng, Hongmei Wu, Shidong Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary Thyroid Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Biosci (Landmark Ed) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31083/j.fbl2808162"}], "href": "https://doi.org/10.31083/j.fbl2808162"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37664917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37664917"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Linyu Han, Yanfei Huo, Linying Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide functional integration identified MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Toxicol (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00204-023-03669-z"}], "href": "https://doi.org/10.1007/s00204-023-03669-z"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38189915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38189915"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Wenmeng Wang, Dangdang Li, Qingqing Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "G-quadruplexes promote the motility in MAZ phase-separated condensates to activate CCND1 expression and contribute to hepatocarcinogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-024-45353-5"}], "href": "https://doi.org/10.1038/s41467-024-45353-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "38316778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/38316778"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Josué Álvaro-Blanco, Katia Urso, Yuri Chiodo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAZ induces MYB expression during the exit from quiescence via the E2F site in the MYB promoter."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx641"}], "href": "https://doi.org/10.1093/nar/gkx641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28973440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28973440"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "C Leroy, D Manen, R Rizzoli, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional importance of Myc-associated zinc finger protein for the human parathyroid hormone (PTH)/PTH-related peptide receptor-1 P2 promoter constitutive activity."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Mol Endocrinol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1677/jme.0.0320099"}], "href": "https://doi.org/10.1677/jme.0.0320099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "14765995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/14765995"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Deepak Kumar, Alpana Ray, Bimal K Ray "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional synergy mediated by SAF-1 and AP-1: critical role of N-terminal polyalanine and two zinc finger domains of SAF-1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M806289200"}], "href": "https://doi.org/10.1074/jbc.M806289200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19028685"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19028685"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Alpana Ray, Arvind Shakya, Deepak Kumar, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of serum amyloid A-activating factor 1 inhibits cell proliferation by the induction of cyclin-dependent protein kinase inhibitor p21WAF-1/Cip-1/Sdi-1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2004)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.172.8.5006"}], "href": "https://doi.org/10.4049/jimmunol.172.8.5006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15067082"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15067082"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Bin Liu, Anyun Ma, Feng Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep21534"}], "href": "https://doi.org/10.1038/srep21534"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26867947"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26867947"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Jianbo Ren, Dawei Guo, Xiaoyi Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Revealing the alternative promoter usage of SAF/MAZ gene by bichromatic fluorescent reporter construct."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20171668"}], "href": "https://doi.org/10.1042/BSR20171668"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30610159"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30610159"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Darya Deen, Falk Butter, Deborah E Daniels, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of the transcription factor MAZ as a regulator of erythropoiesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2021004609"}], "href": "https://doi.org/10.1182/bloodadvances.2021004609"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34351390"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34351390"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Wei-Ping Lee, Keng-Hsin Lan, Chung-Pin Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Akt phosphorylates myc-associated zinc finger protein (MAZ), releases P-MAZ from the p53 promoter, and activates p53 transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Lett (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.canlet.2016.02.023"}], "href": "https://doi.org/10.1016/j.canlet.2016.02.023"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26902421"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26902421"}]}, {"type": "r", "ref": 24, "children": [{"type": "t", "text": "Bimal K Ray, Ryan Murphy, Papiya Ray, et al. "}, {"type": "b", "children": [{"type": "t", "text": "SAF-2, a splice variant of SAF-1, acts as a negative regulator of transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M206299200"}], "href": "https://doi.org/10.1074/jbc.M206299200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12270922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12270922"}]}, {"type": "r", "ref": 25, "children": [{"type": "t", "text": "Bimal K Ray, Arvind Shakya, Alpana Ray "}, {"type": "b", "children": [{"type": "t", "text": "Vascular endothelial growth factor expression in arthritic joint is regulated by SAF-1 transcription factor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4049/jimmunol.178.3.1774"}], "href": "https://doi.org/10.4049/jimmunol.178.3.1774"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17237427"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17237427"}]}, {"type": "r", "ref": 26, "children": [{"type": "t", "text": "Diana Ernst, Desiree Weiberg, Niklas T Baerlecken, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Anti-MYC-associated zinc finger protein antibodies are associated with inflammatory atherosclerotic lesions on "}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "18"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": "F-fluorodeoxyglucose positron emission tomography."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Atherosclerosis (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.atherosclerosis.2017.02.010"}], "href": "https://doi.org/10.1016/j.atherosclerosis.2017.02.010"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28279832"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28279832"}]}, {"type": "r", "ref": 27, "children": [{"type": "t", "text": "Hsiu-Yu Wang, Hao-Teng Chang, Tun-Wen Pai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Mol Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2199-8-89"}], "href": "https://doi.org/10.1186/1471-2199-8-89"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17927842"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17927842"}]}, {"type": "r", "ref": 28, "children": [{"type": "t", "text": "Seyede Zahra Nazari Mehrabani, Mohammad Hossein Shushizadeh, Mohammad Foad Abazari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of SHMT1, MAZ, ERG, and L3MBTL3 Gene Polymorphisms with Susceptibility to Multiple Sclerosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Genet (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10528-018-9894-1"}], "href": "https://doi.org/10.1007/s10528-018-9894-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30456721"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30456721"}]}]}]}