MBD1 Gene

HGNC Family	Zinc fingers
Name	methyl-CpG binding domain protein 1
Description	The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMethyl‐CpG binding domain protein 1 (MBD1) serves as a key interpreter of DNA methylation marks by specifically binding methylated CpG dinucleotides and directing chromatin modifications that culminate in transcriptional repression. MBD1 exerts its repressive functions by recruiting chromatin‐modifying enzymes – including histone methyltransferases such as Suv39h1 and SETDB1, histone deacetylases, and adaptor factors such as MCAF – which together promote heterochromatin formation and the stable silencing of target genes. In this capacity, MBD1 is central to epigenetic gene regulation as demonstrated by its ability to tether heterochromatin proteins like HP1 to methylated DNA and function through multiple repression domains."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its role in chromatin remodeling, MBD1 interacts with a range of nuclear factors that expand its functional repertoire. It has been observed to colocalize with proteins involved in developmental and immune regulatory pathways—for example, by interacting with the intracellular domain of teneurin‐1 and with the transcriptional regulator Aire to help target tissue‐specific genes in the thymus. MBD1 also modulates the activity of Tet1, thereby enhancing 5‑methylcytosine oxidation at heterochromatic regions, and its binding to nucleosomal DNA exhibits sequence‐dependent preferences that can alter local chromatin conformation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nDysregulation of MBD1 has been linked to oncogenesis and aberrant cellular responses. In several cancers—including pancreatic, prostate, lung, and colorectal malignancies—alterations in MBD1 expression and function have been implicated in the promotion of invasive behavior, epithelial‐to‐mesenchymal transition, poor clinical prognosis, and altered responses to DNA damage. For instance, overexpression of MBD1 has been shown to foster epithelial–mesenchymal transition via its association with factors such as Twist and SIRT1, while its recruitment to sites of DNA damage contributes to chemoradioresistance. Moreover, functional polymorphisms in the MBD1 gene appear to modulate cancer susceptibility as well as tumor suppressor gene expression through changes in promoter methylation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "17"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent structural and biophysical studies have further clarified the molecular underpinnings of MBD1 function. Molecular dynamics simulations have revealed that the methyl‐CpG binding domain of MBD1 recognizes methylated DNA through additive contributions from individual methyl groups, with distinct recognition features on opposite DNA strands. Such insights into the atomic interactions and conformational adaptations underlying MBD1 binding provide a framework for understanding how its differential association with chromatin influences epigenetic states and cellular outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Naoyuki Fujita, Sugiko Watanabe, Takaya Ichimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCAF mediates MBD1-dependent transcriptional repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.23.8.2834-2843.2003"}], "href": "https://doi.org/10.1128/MCB.23.8.2834-2843.2003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12665582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12665582"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Naoyuki Fujita, Sugiko Watanabe, Takaya Ichimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M302283200"}], "href": "https://doi.org/10.1074/jbc.M302283200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12711603"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12711603"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Takaya Ichimura, Sugiko Watanabe, Yasuo Sakamoto, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M413654200"}], "href": "https://doi.org/10.1074/jbc.M413654200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15691849"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15691849"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yasuo Sakamoto, Sugiko Watanabe, Takaya Ichimura, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overlapping roles of the methylated DNA-binding protein MBD1 and polycomb group proteins in transcriptional repression of HOXA genes and heterochromatin foci formation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M700011200"}], "href": "https://doi.org/10.1074/jbc.M700011200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17428788"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17428788"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Frank Wischnewski, Olaf Friese, Klaus Pantel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-06-0364"}], "href": "https://doi.org/10.1158/1541-7786.MCR-06-0364"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17634428"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17634428"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Samantha M Nunes, Jacqueline Ferralli, Karen Choi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The intracellular domain of teneurin-1 interacts with MBD1 and CAP/ponsin resulting in subcellular codistribution and translocation to the nuclear matrix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Exp Cell Res (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.yexcr.2004.12.020"}], "href": "https://doi.org/10.1016/j.yexcr.2004.12.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15777793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15777793"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Michael Waterfield, Imran S Khan, Jessica T Cortez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Immunol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ni.2820"}], "href": "https://doi.org/10.1038/ni.2820"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24464130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24464130"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Agnes Mendonca, Oscar F Sanchez, Wenjie Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CpG dinucleotide positioning patterns determine the binding affinity of methyl-binding domain to nucleosomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta Gene Regul Mech (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbagrm.2017.03.006"}], "href": "https://doi.org/10.1016/j.bbagrm.2017.03.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28377300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28377300"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Peng Zhang, Cathia Rausch, Florian D Hastert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG binding domain protein 1 regulates localization and activity of Tet1 in a CXXC3 domain-dependent manner."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkx281"}], "href": "https://doi.org/10.1093/nar/gkx281"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28449087"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28449087"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Chen Liu, Yaohui Chen, Xianjun Yu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic analysis of differential proteins in pancreatic carcinomas: Effects of MBD1 knock-down by stable RNA interference."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2407-8-121"}], "href": "https://doi.org/10.1186/1471-2407-8-121"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18445260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18445260"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Ahmed Yaqinuddin, Farhat Abbas, Syed Z Naqvi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of MBD1 and MeCP2 in prostate-cancer-derived PC3 cells produces differential gene expression profiles and cellular phenotypes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biosci Rep (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BSR20080032"}], "href": "https://doi.org/10.1042/BSR20080032"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18666890"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18666890"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Hongliang Liu, Guangfu Jin, Haifeng Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomarkers (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/13547500802168031"}], "href": "https://doi.org/10.1080/13547500802168031"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18668384"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18668384"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Seul Ki Park, Yu Mi Jeon, Bu Soon Son, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Proteomic analysis of the differentially expressed proteins by airborne nanoparticles."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Appl Toxicol (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jat.1658"}], "href": "https://doi.org/10.1002/jat.1658"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21491466"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21491466"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "J Xu, W Zhu, W Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Up-regulation of MBD1 promotes pancreatic cancer cell epithelial-mesenchymal transition and invasion by epigenetic down-regulation of E-cadherin."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Mol Med (2013)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23331011"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23331011"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Jin Xu, Wenwei Zhu, Wenyan Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of MBD1 reverses pancreatic cancer therapy resistance through inhibition of DNA damage repair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2013.1901"}], "href": "https://doi.org/10.3892/ijo.2013.1901"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23588667"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23588667"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "B Zhang, J Xu, C Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Mol Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2174/1566524016666160316154150"}], "href": "https://doi.org/10.2174/1566524016666160316154150"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26980696"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26980696"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Lu Qi, Yanqing Ding "}, {"type": "b", "children": [{"type": "t", "text": "Screening of Tumor Suppressor Genes in Metastatic Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2017/2769140"}], "href": "https://doi.org/10.1155/2017/2769140"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28473981"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28473981"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Caterina Bianchi, Ronen Zangi "}, {"type": "b", "children": [{"type": "t", "text": "Molecular dynamics study of the recognition of dimethylated CpG sites by MBD1 protein."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Chem Inf Model (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/ci500657d"}], "href": "https://doi.org/10.1021/ci500657d"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25658035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25658035"}]}]}]}
Synonyms	PCM1, CXXC3, RFT
Proteins	MBD1_HUMAN
NCBI Gene ID	4152
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MBD1 has 7,137 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 121 datasets.

Click the + buttons to view associations for MBD1 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MBD1 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MBD1 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MBD1 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MBD1 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MBD1 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MBD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MBD1 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MBD1 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MBD1 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MBD1 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MBD1 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MBD1 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MBD1 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MBD1 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MBD1 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MBD1 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MBD1 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MBD1 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MBD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MBD1 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MBD1 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MBD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MBD1 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MBD1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MBD1 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MBD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MBD1 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MBD1 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MBD1 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MBD1 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MBD1 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MBD1 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MBD1 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MBD1 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MBD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MBD1 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MBD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MBD1 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MBD1 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MBD1 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MBD1 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.