MBD5 Gene

Name	methyl-CpG binding domain protein 5
Description	This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause an autosomal dominant type of cognitive disability. The encoded protein interacts with the polycomb repressive complex PR-DUB which catalyzes the deubiquitination of a lysine residue of histone 2A. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined. [provided by RefSeq, Jul 2017]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMBD5 is a dosage‐sensitive gene that plays a critical role in neurodevelopment. Multiple studies have shown that deletions, intragenic disruptions, or duplications of MBD5 are robustly associated with a broad spectrum of clinical features, including intellectual disability, autistic spectrum behaviors, seizures, language deficits, and behavioral abnormalities. Importantly, both loss‐of‐function and increased gene dosage of MBD5—whether through complete gene deletions, disruption of noncoding regulatory elements, or duplications of the 2q23.1 region—result in similar neurodevelopmental deficits. These clinical observations underscore that even subtle perturbations of MBD5 expression can disturb the balance of neurological function and lead to overlapping syndromic presentations, such as sleep disturbances, epileptic syndromes, and neuropsychiatric regression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "12"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAt the molecular level, MBD5 encodes a protein that contains a methyl‐CpG–binding domain—a module classically implicated in recognizing DNA methylation marks. However, unlike its better‐characterized relatives (for example, MECP2), direct binding of MBD5 to methylated DNA remains ambiguous. Instead, evidence suggests that the MBD domain of MBD5 is both necessary and sufficient for mediating critical protein–protein interactions, notably with components of the PR-DUB complex, hinting at its role in chromatin remodeling and the epigenetic regulation of gene expression. Furthermore, comparative analyses within the MBD gene family in neurodevelopmental disorders have implicated MBD5 in collaborative networks likely essential for orchestrating neural gene expression during brain development."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent technological advances—including high‐resolution array comparative genomic hybridization, exome/genome sequencing, and studies in neural stem cells—have refined our understanding of MBD5’s genomic architecture and regulatory role. These studies reveal that even small intragenic or noncoding alterations can lead to haploinsufficiency and aberrant mRNA expression, thereby disrupting the delicate equilibrium between neural stem cell proliferation and differentiation. In addition, long-read sequencing approaches have uncovered novel structural variants, further broadening the spectrum of pathogenic alterations that impact MBD5 function. Together, these insights not only solidify the significance of proper MBD5 dosage for normal neurodevelopment but also underscore its central role in mediating complex epigenetic and transcriptional networks."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "17", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stephen R Williams, Sureni V Mullegama, Jill A Rosenfeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Haploinsufficiency of MBD5 associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2009.199"}], "href": "https://doi.org/10.1038/ejhg.2009.199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19904302"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19904302"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Brian H Y Chung, James Stavropoulos, Christian R Marshall, et al. "}, {"type": "b", "children": [{"type": "t", "text": "2q23 de novo microdeletion involving the MBD5 gene in a patient with developmental delay, postnatal microcephaly and distinct facial features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.33821"}], "href": "https://doi.org/10.1002/ajmg.a.33821"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21271666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21271666"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Michael E Talkowski, Sureni V Mullegama, Jill A Rosenfeld, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Assessment of 2q23.1 microdeletion syndrome implicates MBD5 as a single causal locus of intellectual disability, epilepsy, and autism spectrum disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Hum Genet (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ajhg.2011.09.011"}], "href": "https://doi.org/10.1016/j.ajhg.2011.09.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21981781"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21981781"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Céline Bonnet, Asma Ali Khan, Emmanuel Bresso, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Extended spectrum of MBD5 mutations in neurodevelopmental disorders."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2013.22"}], "href": "https://doi.org/10.1038/ejhg.2013.22"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23422940"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23422940"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "J C Hodge, E Mitchell, V Pillalamarri, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Psychiatry (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/mp.2013.42"}], "href": "https://doi.org/10.1038/mp.2013.42"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23587880"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23587880"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Sureni V Mullegama, Jill A Rosenfeld, Carmen Orellana, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Reciprocal deletion and duplication at 2q23.1 indicates a role for MBD5 in autism spectrum disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2013.67"}], "href": "https://doi.org/10.1038/ejhg.2013.67"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23632792"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23632792"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Sureni V Mullegama, Loren Pugliesi, Brooke Burns, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD5 haploinsufficiency is associated with sleep disturbance and disrupts circadian pathways common to Smith-Magenis and fragile X syndromes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2014.200"}], "href": "https://doi.org/10.1038/ejhg.2014.200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25271084"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25271084"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Sureni V Mullegama, Joseph T Alaimo, Li Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phenotypic and molecular convergence of 2q23.1 deletion syndrome with other neurodevelopmental syndromes associated with autism spectrum disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms16047627"}], "href": "https://doi.org/10.3390/ijms16047627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25853262"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25853262"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ji Yoon Han, In Goo Lee, Woori Jang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Diagnostic exome sequencing identifies a heterozygous MBD5 frameshift mutation in a family with intellectual disability and epilepsy."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Med Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ejmg.2017.08.003"}], "href": "https://doi.org/10.1016/j.ejmg.2017.08.003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28807762"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28807762"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Guillermo González-Ortega, Sara Llamas-Velasco, Ana Arteche-López, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Early-Onset Dementia Associated with a Heterozygous, Nonsense, and de novo Variant in the MBD5 Gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-210648"}], "href": "https://doi.org/10.3233/JAD-210648"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34459404"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34459404"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "X W Jing, M M Cheng, X Y Niu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "[Clinical phenotypes and genetic features of epilepsy children with MBD5 gene variants]."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Zhonghua Er Ke Za Zhi (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3760/cma.j.cn112140-20211015-00874"}], "href": "https://doi.org/10.3760/cma.j.cn112140-20211015-00874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35385942"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35385942"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Mehak Bhatia, Gianpiero L Cavalleri, Máire White, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Germline mosaicism in a family with "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MBD5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " haploinsufficiency."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cold Spring Harb Mol Case Stud (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/mcs.a006253"}], "href": "https://doi.org/10.1101/mcs.a006253"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36396431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36396431"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Sophie Laget, Michael Joulie, Florent Le Masson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The human proteins MBD5 and MBD6 associate with heterochromatin but they do not bind methylated DNA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0011982"}], "href": "https://doi.org/10.1371/journal.pone.0011982"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20700456"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20700456"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Holly N Cukier, Joycelyn M Lee, Deqiong Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The expanding role of MBD genes in autism: identification of a MECP2 duplication and novel alterations in MBD5, MBD6, and SETDB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Autism Res (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/aur.1251"}], "href": "https://doi.org/10.1002/aur.1251"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23055267"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23055267"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "H Irem Baymaz, Alexandra Fournier, Sophie Laget, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MBD5 and MBD6 interact with the human PR-DUB complex through their methyl-CpG-binding domain."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proteomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/pmic.201400013"}], "href": "https://doi.org/10.1002/pmic.201400013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24634419"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24634419"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "C O Gigek, E S Chen, V K Ota, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Copy number variants analysis in a cohort of isolated and syndromic developmental delay/intellectual disability reveals novel genomic disorders, position effects and candidate disease genes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cge.13009"}], "href": "https://doi.org/10.1111/cge.13009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28295210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28295210"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Thanh Nha Uyen Le, Thi Minh Thi Ha "}, {"type": "b", "children": [{"type": "t", "text": "MBD5-related intellectual disability in a Vietnamese child."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.62077"}], "href": "https://doi.org/10.1002/ajmg.a.62077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33427406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33427406"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Sachiko Ohori, Rie S Tsuburaya, Masako Kinoshita, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long-read whole-genome sequencing identified a partial MBD5 deletion in an exome-negative patient with neurodevelopmental disorder."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s10038-020-00893-8"}], "href": "https://doi.org/10.1038/s10038-020-00893-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33510365"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33510365"}]}]}]}
Synonyms	MRD1
Proteins	MBD5_HUMAN
NCBI Gene ID	55777
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MBD5 has 9,486 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 117 datasets.

Click the + buttons to view associations for MBD5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MBD5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MBD5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MBD5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MBD5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MBD5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MBD5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MBD5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MBD5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MBD5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MBD5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MBD5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MBD5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MBD5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MBD5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MBD5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MBD5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MBD5 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MBD5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MBD5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MBD5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MBD5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MBD5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MBD5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MBD5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MBD5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MBD5 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MBD5 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MBD5 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MBD5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MBD5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MBD5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MBD5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MBD5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MBD5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MBD5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MBD5 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MBD5 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MBD5 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GAD High Level Gene-Disease Associations	diseases associated with MBD5 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MBD5 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MBD5 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.