MCC Gene

HGNC Family	EF-hand domain containing
Name	mutated in colorectal cancers
Description	This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMCC functions as a tumor suppressor that regulates key signaling and cell‐cycle pathways in several cancer types. In hepatocellular carcinoma, aberrant up‐regulation of microRNAs (e.g. miR‐494) targets MCC to promote the G1/S cell‐cycle transition and transformation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, MCC is a nuclear protein that directly interacts with β‐catenin to inhibit its transcriptional activity and dampen oncogenic Wnt signaling"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while loss of MCC expression—via promoter methylation or miRNA‐mediated suppression (e.g. by miR‐4260)—enhances cell proliferation, migration and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Moreover, MCC engages with DBC1 to facilitate β‐catenin deacetylation, thereby providing an APC‐independent mechanism for β‐catenin repression; similar tumor‐suppressive roles have been observed in breast cancer, where MCC alterations correlate with increased nuclear β‐catenin and poor clinical outcome."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": " In addition, studies evaluating MCC’s potential role in modulating NFκB signaling in colorectal cancer further underscore its multifaceted regulatory functions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond these cell‐proliferative and signaling roles, MCC acts as a scaffold protein that governs cell adhesion and migration. Its ability to interact with the polarity protein Scribble and the E‐cadherin/β‐catenin complex is critical for maintaining cell–cell contacts; loss of MCC impairs E‐cadherin levels, disrupts adhesion and thereby promotes cellular invasiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Furthermore, MCC contains a PDZ-binding motif whose phosphorylation (at serine 828) enhances its binding to Scribble and downstream partners such as Myosin-IIB. This post-translational modification is key to regulating lamellipodia formation and cell migration, as further supported by biophysical NMR studies that elucidate the directionality and nature of these PDZ-mediated interactions."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMCC expression is also modulated by genetic and epigenetic mechanisms that differ among diseases. In colorectal cancer, promoter methylation and allele-specific expression changes of MCC have been linked to increased tumor risk, whereas in lung cancer MCC is not commonly epigenetically silenced and its expression levels vary between patients."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " Genetic association studies have further shown that, although MCC genetic variants do not appear to influence atopic dermatitis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", differential expression or polymorphisms in MCC may contribute to cancer susceptibility—for instance, by conferring distinct risks in colorectal cancer as well as by acting as a potential secondary effector in B cell transformation in TRAF3-deficient lymphomas."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": " Emerging evidence from familial lung cancer studies also suggests that investigation of MCC as part of the wider network of genetic risk factors might offer further insights into its context-dependent roles."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lionel Lim, Asha Balakrishnan, Noelle Huskey, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hepatology (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/hep.26662"}], "href": "https://doi.org/10.1002/hep.26662"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23913442"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23913442"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "R Fukuyama, R Niculaita, K P Ng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2008.204"}], "href": "https://doi.org/10.1038/onc.2008.204"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18591935"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18591935"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Junjie Xiao, Dongchao Lv, Jinzhe Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Theranostics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7150/thno.19168"}], "href": "https://doi.org/10.7150/thno.19168"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28638476"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28638476"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Laurent Pangon, Dessislava Mladenova, Lauren Watkins, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.28967"}], "href": "https://doi.org/10.1002/ijc.28967"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24824780"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24824780"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Nupur Mukherjee, Hemantika Dasgupta, Rittwika Bhattacharya, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbadis.2016.05.009"}], "href": "https://doi.org/10.1016/j.bbadis.2016.05.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27208794"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27208794"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Nupur Mukherjee, Nilanjana Bhattacharya, Satyabrata Sinha, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of APC and MCC polymorphisms with increased breast cancer risk in an Indian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biol Markers (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5301/jbm.2011.6266"}], "href": "https://doi.org/10.5301/jbm.2011.6266"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21279955"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21279955"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Nicholas D Sigglekow, Laurent Pangon, Tilman Brummer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutated in colorectal cancer protein modulates the NFκB pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Anticancer Res (2012)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22213290"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22213290"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "F A Benthani, D Herrmann, P N Tran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "'MCC' protein interacts with E-cadherin and β-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2017.362"}], "href": "https://doi.org/10.1038/onc.2017.362"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29035389"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29035389"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Laurent Pangon, Christa Van Kralingen, Melissa Abas, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochim Biophys Acta (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbamcr.2012.03.011"}], "href": "https://doi.org/10.1016/j.bbamcr.2012.03.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22480440"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22480440"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Camille Arnaud, Michaël Sebbagh, Sébastien Nola, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "FEBS Lett (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.febslet.2009.06.034"}], "href": "https://doi.org/10.1016/j.febslet.2009.06.034"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19555689"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19555689"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Gustav N Sundell, Beat Vögeli, Ylva Ivarsson, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.biochem.7b00965"}], "href": "https://doi.org/10.1021/acs.biochem.7b00965"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29144123"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29144123"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Jinglu Zhao, Xiaoli Xie, Yuxiao Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101423"}], "href": "https://doi.org/10.18632/aging.101423"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29695640"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29695640"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "E Pascale, L Tarani, P Meglio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Hered (2001)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1159/000053339"}], "href": "https://doi.org/10.1159/000053339"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11173969"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11173969"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Shanique K E Edwards, Jacqueline Baron, Carissa R Moore, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hematol Oncol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13045-014-0056-6"}], "href": "https://doi.org/10.1186/s13045-014-0056-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25200342"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25200342"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Yang Wang, Yanfei Cao, Xiaoye Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep26688"}], "href": "https://doi.org/10.1038/srep26688"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27226254"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27226254"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Ning Xiao, Xiaoqing Cao, Zhidong Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two germline mutations can serve as genetic susceptibility screening makers for a lung adenocarcinoma family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cancer Res Clin Oncol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00432-023-04616-2"}], "href": "https://doi.org/10.1007/s00432-023-04616-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36781503"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36781503"}]}]}]}
Synonyms	MCC1
Proteins	CRCM_HUMAN
NCBI Gene ID	4163
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MCC has 6,723 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 126 datasets.

Click the + buttons to view associations for MCC from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MCC Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCC gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCC gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MCC gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MCC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MCC gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCC gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MCC gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCC gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MCC gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MCC gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MCC gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MCC protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MCC gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCC gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MCC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MCC gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MCC protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MCC gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MCC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MCC protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MCC protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MCC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MCC protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MCC protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MCC gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MCC gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MCC gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MCC gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MCC protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MCC gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MCC gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MCC gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MCC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MCC gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MCC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MCC gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MCC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MCC gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MCC gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCC gene from the ENCODE Transcription Factor Binding Site Profiles dataset.