MCM5 Gene

Name	minichromosome maintenance complex component 5
Description	The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMCM5 is a core subunit of the MCM2–7 helicase complex that plays essential roles in DNA replication and has emerged as a multifunctional regulator in eukaryotic cells. Beyond its canonical function in replication licensing, MCM5 is also recruited to gene promoters—for example, at Stat1 target genes upon cytokine stimulation—and travels with RNA polymerase II during transcription elongation, thereby contributing to transcription activation. Additionally, MCM5 participates in the dynamic loading and unloading of the replicative helicase on chromatin, an event mediated in part by its association with accessory factors."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nA number of studies have demonstrated that MCM5 is subject to extensive post‐transcriptional regulation in cancer cells. In neuroblastoma, for example, miRNA-mediated downregulation (via miR-885-5p and miR-183) leads to decreased MCM5 expression that correlates with cell cycle arrest and apoptosis, reinforcing its importance for cell proliferation. Similarly, in anaplastic thyroid carcinoma treatment by bromodomain and extra-terminal inhibitors results in downregulation of MCM5, and in acute myeloid leukemia, modulation by the CRNDE/miR-136-5p regulatory axis further emphasizes its role in tumor cell survival. In hepatocellular carcinoma, miR-3607 similarly targets MCM5 to inhibit malignant behavior."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "9"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nOverexpression of MCM5 is observed in a broad spectrum of human malignancies, where its elevated levels correlate with increased cell proliferation and poor clinical prognosis. For instance, its rising mRNA levels are associated with progression from normal to dysplastic and malignant lesions in cervical and colon cancers, while enhanced protein expression has been linked to aggressive behavior in adrenocortical, laryngeal, lung, and bladder cancers. In various tumor types, MCM5 not only serves as an informative diagnostic and prognostic biomarker but its promoter has even been explored as a tool for cancer-targeted gene delivery. Furthermore, mutations in MCM5 have been identified in developmental disorders such as Meier-Gorlin syndrome, underscoring its critical role in cell cycle progression in both physiological and pathological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "10", "end_ref": "19"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nRecent evidence further illustrates that MCM5 expression can be modulated by epitranscriptomic mechanisms. In lung adenocarcinoma, for instance, m6A-dependent stabilization of MCM5 mRNA by the m6A reader IGF2BP3 leads to enhanced protein expression that contributes to cellular plasticity and metastasis. Collectively, these studies underscore that MCM5 is not only pivotal for ensuring proper DNA replication and transcription but is also intricately involved in malignant transformation and progression, making it an attractive target for both prognostic evaluation and therapeutic intervention."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jasminka Boskovic, Javier Coloma, Tomás Aparicio, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular architecture of the human GINS complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "EMBO Rep (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.embor.7401002"}], "href": "https://doi.org/10.1038/sj.embor.7401002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17557111"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17557111"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marylynn Snyder, Wei He, J Jillian Zhang "}, {"type": "b", "children": [{"type": "t", "text": "The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.0507479102"}], "href": "https://doi.org/10.1073/pnas.0507479102"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16199513"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16199513"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Marylynn Snyder, Xin-Yun Huang, J Jillian Zhang "}, {"type": "b", "children": [{"type": "t", "text": "The minichromosome maintenance proteins 2-7 (MCM2-7) are necessary for RNA polymerase II (Pol II)-mediated transcription."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M809471200"}], "href": "https://doi.org/10.1074/jbc.M809471200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19318354"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19318354"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Madhav Jagannathan, Tin Nguyen, David Gallo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for USP7 in DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00639-13"}], "href": "https://doi.org/10.1128/MCB.00639-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24190967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24190967"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "E A Afanasyeva, P Mestdagh, C Kumps, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MicroRNA miR-885-5p targets CDK2 and MCM5, activates p53 and inhibits proliferation and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Differ (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/cdd.2010.164"}], "href": "https://doi.org/10.1038/cdd.2010.164"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21233845"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21233845"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Catia Mio, Elisa Lavarone, Ketty Conzatti, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM5 as a target of BET inhibitors in thyroid cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocr Relat Cancer (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1530/ERC-15-0322"}], "href": "https://doi.org/10.1530/ERC-15-0322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26911376"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26911376"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Marco Lodrini, Gereon Poschmann, Victoria Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Minichromosome Maintenance Complex Is a Critical Node in the miR-183 Signaling Network of MYCN-Amplified Neuroblastoma Cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Proteome Res (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/acs.jproteome.6b00134"}], "href": "https://doi.org/10.1021/acs.jproteome.6b00134"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27239679"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27239679"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Wen-Yu Hu, Hai-Yan Wei, Lu-Yun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "miR-3607, a biomarker of hepatocellular carcinoma invasion and aggressiveness: Its relationship with epithelial-mesenchymal transition process."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "IUBMB Life (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/iub.2291"}], "href": "https://doi.org/10.1002/iub.2291"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32311821"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32311821"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Chen Liu, Liang Zhong, Chenlan Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "CRNDE enhances the expression of MCM5 and proliferation in acute myeloid leukemia KG-1a cells by sponging miR-136-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-021-96156-3"}], "href": "https://doi.org/10.1038/s41598-021-96156-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34408205"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34408205"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Niamh Murphy, Martina Ring, Cynthia C B B Heffron, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/modpathol.3800361"}], "href": "https://doi.org/10.1038/modpathol.3800361"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "15696126"}], "href": "https://pubmed.ncbi.nlm.nih.gov/15696126"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Constantinos Giaginis, Maria Georgiadou, Konstantina Dimakopoulou, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Cancer-specific promoters for expression-targeted gene therapy: ran, brms1 and mcm5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.2882"}], "href": "https://doi.org/10.1002/jgm.2882"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27140445"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27140445"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Annalisa Vetro, Salvatore Savasta, Annalisa Russo Raucci, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCM5: a new actor in the link between DNA replication and Meier-Gorlin syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur J Hum Genet (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ejhg.2017.5"}], "href": "https://doi.org/10.1038/ejhg.2017.5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28198391"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28198391"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dan Wang, Qian Li, Yichun Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "MCM5 urine expression (ADXBLADDER) is a reliable biomarker of high-risk non- muscle-invasive bladder cancer recurrence: A prospective matched case-control study."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Biomark (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/CBM-200316"}], "href": "https://doi.org/10.3233/CBM-200316"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32924986"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32924986"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Xia Yang, Qiaorui Bai, Weizhong Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "m"}, {"type": "a", "children": [{"type": "t", "text": "sup"}], "href": "sup"}, {"type": "t", "text": "6"}, {"type": "a", "children": [{"type": "t", "text": "/sup"}], "href": "/sup"}, {"type": "t", "text": " A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes Partial EMT and LUAD Metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Adv Sci (Weinh) (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/advs.202206744"}], "href": "https://doi.org/10.1002/advs.202206744"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37171793"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37171793"}]}]}]}
Synonyms	CDC46, MGORS8, P1-CDC46
Proteins	MCM5_HUMAN
NCBI Gene ID	4174
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MCM5 has 12,702 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 134 datasets.

Click the + buttons to view associations for MCM5 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MCM5 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Achilles Cell Line Gene Essentiality Profiles	cell lines with fitness changed by MCM5 gene knockdown relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCM5 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCM5 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MCM5 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MCM5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MCM5 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCM5 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	Biocarta Pathways	pathways involving MCM5 protein from the Biocarta Pathways dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MCM5 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCM5 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCM5 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MCM5 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MCM5 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MCM5 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MCM5 protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MCM5 gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCM5 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MCM5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MCM5 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MCM5 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MCM5 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MCM5 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MCM5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MCM5 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MCM5 protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MCM5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MCM5 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MCM5 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MCM5 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MCM5 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MCM5 gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MCM5 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MCM5 protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MCM5 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MCM5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MCM5 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MCM5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MCM5 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MCM5 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCM5 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.