MCMBP Gene

Name	minichromosome maintenance complex binding protein
Description	This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMCMBP (minichromosome maintenance complex‑binding protein) is a conserved replication factor that modulates the dynamics of the replicative helicase. In human cells, a variant MCM complex incorporating MCMBP—formed with MCM3, MCM4, MCM5, MCM6, and MCM7, but excluding MCM2—has been identified, suggesting that MCMBP can contribute to alternative MCM assemblies that may possess increased stability under certain conditions."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In Xenopus egg extracts, MCMBP has been shown to disassemble the MCM2‑7 hexamer from chromatin in late S phase, acting as an unloader that clears replication machinery off replicated DNA."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, its loss leads to replication‑dependent defects—including replication stress, abnormal nuclear morphology, and centrosome amplification—highlighting an essential role in maintaining genome stability."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn addition to its roles in MCM complex assembly and disassembly, MCMBP participates in regulatory events that fine‑tune DNA replication. It interacts with the Dbf4 regulatory subunit of DDK, modulating DDK‑mediated phosphorylation of critical MCM proteins"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", and associates with the ubiquitin‑specific protease USP7 on chromatin to tether USP7 to MCM complexes, further influencing MCM turnover during mid‑to‑late S phase."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Notably, deregulation of MCMBP—whether by knockdown or overexpression—leads to aberrant sister chromatid cohesion and the emergence of cells with abnormal nuclear morphology, a phenomenon observed in various carcinomas and associated with an increased relapse risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, MCMBP plays a critical role in assembling the MCM2‑7 hexamer by incorporating nascent MCM3, thereby ensuring efficient replication licensing and proper cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Amos M Sakwe, Tin Nguyen, Vicki Athanasopoulos, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification and characterization of a novel component of the human minichromosome maintenance complex."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.02384-06"}], "href": "https://doi.org/10.1128/MCB.02384-06"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17296731"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17296731"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Atsuya Nishiyama, Lori Frappier, Marcel Méchali "}, {"type": "b", "children": [{"type": "t", "text": "MCM-BP regulates unloading of the MCM2-7 helicase in late S phase."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Dev (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1101/gad.614411"}], "href": "https://doi.org/10.1101/gad.614411"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21196493"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21196493"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Madhav Jagannathan, Amos M Sakwe, Tin Nguyen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The MCM-associated protein MCM-BP is important for human nuclear morphology."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.089938"}], "href": "https://doi.org/10.1242/jcs.089938"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22250201"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22250201"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Tin Nguyen, Madhav Jagannathan, Kathy Shire, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Interactions of the human MCM-BP protein with MCM complex components and Dbf4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0035931"}], "href": "https://doi.org/10.1371/journal.pone.0035931"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22540012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22540012"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Madhav Jagannathan, Tin Nguyen, David Gallo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A role for USP7 in DNA replication."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/MCB.00639-13"}], "href": "https://doi.org/10.1128/MCB.00639-13"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24190967"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24190967"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Mauricio Quimbaya, Eric Raspé, Geertrui Denecker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Deregulation of the replisome factor MCMBP prompts oncogenesis in colorectal carcinomas through chromosomal instability."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasia (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neo.2014.07.011"}], "href": "https://doi.org/10.1016/j.neo.2014.07.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25246271"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25246271"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yuichiro Saito, Venny Santosa, Kei-Ichiro Ishiguro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Elife (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.7554/eLife.77393"}], "href": "https://doi.org/10.7554/eLife.77393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35438632"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35438632"}]}]}]}
Synonyms	C10ORF119, MCM-BP
Proteins	MCMBP_HUMAN
NCBI Gene ID	79892
API
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Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MCMBP has 5,848 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 109 datasets.

Click the + buttons to view associations for MCMBP from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MCMBP Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCMBP gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MCMBP gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MCMBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MCMBP gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MCMBP gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MCMBP gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCMBP gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MCMBP gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MCMBP gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MCMBP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MCMBP gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MCMBP protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MCMBP gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCMBP gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MCMBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MCMBP gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MCMBP gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MCMBP protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MCMBP gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MCMBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MCMBP protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores	cellular components containing MCMBP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores dataset.
	COMPARTMENTS Experimental Protein Localization Evidence Scores 2025	cellular components containing MCMBP protein in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MCMBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MCMBP protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MCMBP gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MCMBP gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MCMBP gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DeepCoverMOA Drug Mechanisms of Action	small molecule perturbations with high or low expression of MCMBP protein relative to other small molecule perturbations from the DeepCoverMOA Drug Mechanisms of Action dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MCMBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MCMBP gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MCMBP gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MCMBP gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MCMBP gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MCMBP gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MCMBP from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GAD Gene-Disease Associations	diseases associated with MCMBP gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.
	GeneRIF Biological Term Annotations	biological terms co-occuring with MCMBP gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
	GeneSigDB Published Gene Signatures	PubMedIDs of publications reporting gene signatures containing MCMBP from the GeneSigDB Published Gene Signatures dataset.
	GEO Signatures of Differentially Expressed Genes for Diseases	disease perturbations changing expression of MCMBP gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.