MECOM Gene

HGNC Family	Zinc fingers
Name	MDS1 and EVI1 complex locus
Description	The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMECOM—commonly referred to by its principal transcript EVI1 or the fusion variant MDS1–EVI1—is a zinc finger transcription factor that normally plays a critical role in regulating hematopoietic stem cell maintenance and self‐renewal. In the physiological state, MECOM contributes to the control of stemness and proper differentiation of hematopoietic cells. However, ectopic activation—whether through gene therapy vector integration, chromosomal rearrangements (such as inv(3)(q21;q26) or t(3;3)), or other mechanisms—can disrupt normal cellular processes. For example, integration events activating MECOM have been shown to expand gene‐corrected myelopoiesis in immune deficiency gene therapy settings, while forced overexpression of EVI1 disrupts normal centrosome duplication and genome stability, linking MECOM activation directly to clonal progression and myelodysplasia."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nAberrant MECOM expression is a key oncogenic driver in acute myeloid leukemia (AML) and other malignancies. In leukemogenesis, MECOM deregulation arises through mechanisms such as enhancer hijacking—where repositioning of a distal GATA2 enhancer ectopically activates MECOM—and through fusion events in MLL‐rearranged leukemias where MECOM is selectively upregulated. Its overexpression leads to epigenetic reprogramming via interactions with histone methyltransferases, repression of TGF‐β/Smad signaling, and modulation of microRNA expression (e.g. miR-9 downregulation), collectively contributing to a block in differentiation, enhanced proliferation, altered cellular metabolism (including reprogramming of the arginine–creatine pathway), and increased adhesion through integrin regulation. Clinically, high MECOM levels serve as an adverse prognostic marker in both adult and pediatric AML, and germline mutations in MECOM are implicated in congenital syndromes marked by bone marrow failure and limb abnormalities, while susceptibility loci involving MECOM have also been linked to nasopharyngeal carcinoma."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "19"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, Claudia Erpelinck, Wim L J van Putten, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2002-05-1459"}], "href": "https://doi.org/10.1182/blood-2002-05-1459"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12393383"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12393383"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Marion G Ott, Manfred Schmidt, Kerstin Schwarzwaelder, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2006)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1393"}], "href": "https://doi.org/10.1038/nm1393"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16582916"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16582916"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Sanne Lugthart, Ellen van Drunen, Yvette van Norden, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimated."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-10-119230"}], "href": "https://doi.org/10.1182/blood-2007-10-119230"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "18272813"}], "href": "https://pubmed.ncbi.nlm.nih.gov/18272813"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "M Shimabe, S Goyama, N Watanabe-Okochi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/onc.2009.288"}], "href": "https://doi.org/10.1038/onc.2009.288"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19767769"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19767769"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "S Goyama, E Nitta, T Yoshino, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EVI-1 interacts with histone methyltransferases SUV39H1 and G9a for transcriptional repression and bone marrow immortalization."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2009.202"}], "href": "https://doi.org/10.1038/leu.2009.202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19776757"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19776757"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Stefan Stein, Marion G Ott, Stephan Schultze-Strasser, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.2088"}], "href": "https://doi.org/10.1038/nm.2088"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20098431"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20098431"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Stefan Gröschel, Sanne Lugthart, Richard F Schlenk, et al. "}, {"type": "b", "children": [{"type": "t", "text": "High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Clin Oncol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1200/JCO.2009.26.0646"}], "href": "https://doi.org/10.1200/JCO.2009.26.0646"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20308656"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20308656"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "B V Balgobind, S Lugthart, I H Hollink, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Leukemia (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/leu.2010.47"}], "href": "https://doi.org/10.1038/leu.2010.47"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20357826"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20357826"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Jin-Xin Bei, Yi Li, Wei-Hua Jia, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2009-07-234310"}], "href": "https://doi.org/10.1182/blood-2009-07-234310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21190993"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21190993"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Norio Yamakawa, Kazuko Kaneda, Yusuke Saito, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The increased expression of integrin α6 (ITGA6) enhances drug resistance in EVI1(high) leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0030706"}], "href": "https://doi.org/10.1371/journal.pone.0030706"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22295105"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22295105"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Emilie A Bard-Chapeau, Justin Jeyakani, Chung H Kok, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1119229109"}], "href": "https://doi.org/10.1073/pnas.1119229109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22308434"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22308434"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Vitalyi Senyuk, Yunyuan Zhang, Yang Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Critical role of miR-9 in myelopoiesis and EVI1-induced leukemogenesis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1302645110"}], "href": "https://doi.org/10.1073/pnas.1302645110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23509296"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23509296"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Stefan Gröschel, Mathijs A Sanders, Remco Hoogenboezem, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2014.02.019"}], "href": "https://doi.org/10.1016/j.cell.2014.02.019"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24703711"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24703711"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Hiromi Yamazaki, Mikiko Suzuki, Akihito Otsuki, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.ccr.2014.02.008"}], "href": "https://doi.org/10.1016/j.ccr.2014.02.008"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24703906"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24703906"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Adil A Hinai, Peter J M Valk "}, {"type": "b", "children": [{"type": "t", "text": "Review: Aberrant EVI1 expression in acute myeloid leukaemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Br J Haematol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/bjh.13898"}], "href": "https://doi.org/10.1111/bjh.13898"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26729571"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26729571"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Pengcheng Bu, Lihua Wang, Kai-Yuan Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Stem Cell (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.stem.2016.01.006"}], "href": "https://doi.org/10.1016/j.stem.2016.01.006"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26849305"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26849305"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Nina Fenouille, Christopher F Bassil, Issam Ben-Sahra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm.4283"}], "href": "https://doi.org/10.1038/nm.4283"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28191887"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28191887"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Manuela Germeshausen, Phil Ancliff, Jaime Estrada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood Adv (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/bloodadvances.2018016501"}], "href": "https://doi.org/10.1182/bloodadvances.2018016501"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29540340"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29540340"}]}]}]}
Synonyms	RUSAT2, EVI1, MDS1, KMT8E, MDS1-EVI1, PRDM3
Proteins	EVI1_HUMAN
NCBI Gene ID	2122
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MECOM has 11,632 functional associations with biological entities spanning 9 categories (molecular profile, organism, disease, phenotype or trait, chemical, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 129 datasets.

Click the + buttons to view associations for MECOM from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MECOM Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MECOM gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MECOM gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MECOM gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MECOM gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MECOM gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MECOM gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MECOM gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MECOM gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MECOM gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MECOM gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MECOM gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Gene Mutation Profiles	cell lines with MECOM gene mutations from the CCLE Cell Line Gene Mutation Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MECOM protein from the CCLE Cell Line Proteomics dataset.
	CellMarker Gene-Cell Type Associations	cell types associated with MECOM gene from the CellMarker Gene-Cell Type Associations dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MECOM gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MECOM gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MECOM gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MECOM gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MECOM gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MECOM protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MECOM protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MECOM protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MECOM protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MECOM gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MECOM gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Chemical Interactions	chemicals interacting with MECOM gene/protein from the curated CTD Gene-Chemical Interactions dataset.
	CTD Gene-Disease Associations	diseases associated with MECOM gene/protein from the curated CTD Gene-Disease Associations dataset.
	dbGAP Gene-Trait Associations	traits associated with MECOM gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MECOM gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MECOM gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores 2025	diseases involving MECOM gene from the DISEASES Curated Gene-Disease Association Evidence Scores 2025 dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores	diseases associated with MECOM gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Experimental Gene-Disease Association Evidence Scores 2025	diseases associated with MECOM gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MECOM gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MECOM gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MECOM gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MECOM gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MECOM gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MECOM gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MECOM gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.