MED23 Gene

Name	mediator complex subunit 23
Description	The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2012]
Summary	{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMED23 is a critical subunit of the Mediator complex that integrates signaling cues to activate transcription. Early studies identified MED23—formerly known as Sur2/DRIP130—as a component that engages with transcriptional activators such as the adenoviral E1A protein and the MAPK-responsive factor ELK1 to mediate serum and mitogen‐stimulated immediate early gene expression (e.g., JUN, FOS, and Egr1). These interactions underpin developmental events and signal-dependent transcriptional activation, demonstrating that distinct activator domains communicate with separate Mediator subunits to initiate gene expression."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nStructural studies have now revealed that MED23 assumes an arch‐shaped conformation composed of HEAT repeat–like motifs organized into multiple α‐solenoids. This structural organization creates extended binding surfaces that facilitate interactions not only with sequence-specific transcription factors but also with elongation regulators such as the P-TEFb complex. By directly binding to CDK9, a key subunit of P-TEFb, MED23 supports the transition of RNA polymerase II into productive elongation, thereby governing a basal level of gene transcription."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncogenesis, MED23 emerges as a multifaceted regulator. Its activity has been implicated in the control of oncogenic drivers in multiple cancers. For example, disrupting the interaction between MED23 (DRIP130) and transcription factors like ESX can lead to a decrease in Her2 expression in breast tumors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", while in melanoma cells, MED23 (as DRIP130) is essential for Sp1-mediated transactivation of the KiSS-1 metastasis suppressor gene."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In lung cancer, MED23 is up-regulated in Ras-active tumor cells and is required for Ras-dependent transformation and sustained proliferative signaling through partnerships with factors such as ELK1 and beta-catenin/TCF, thereby promoting cell-cycle progression and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Furthermore, studies in hepatocellular carcinoma underscore a broader role for MED23 in tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ", and recent work highlights a regulatory axis in non-small cell lung cancer where a MED13L/P300-induced oncogenic lncRNA perturbs alternative polyadenylation of MED23 mRNA, thereby reinforcing oncogenic signaling, as well as MED23’s interplay with BCLAF1 to affect NUPR1-driven autophagic flux and senescence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nMED23 also plays an essential role in brain development and function. Mutations in MED23 have been identified in individuals with nonsyndromic intellectual disability, developmental delay, and refractory epilepsy. These pathogenic variants disrupt the Mediator’s ability to modulate immediate early gene responses and impair neural signaling and energy homeostasis. Detailed clinical reports have expanded the phenotypic spectrum associated with MED23 mutations, reinforcing its critical role in neurogenesis and neuronal maintenance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "14"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jennitte L Stevens, Greg T Cantin, Gang Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1068943"}], "href": "https://doi.org/10.1126/science.1068943"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "11934987"}], "href": "https://pubmed.ncbi.nlm.nih.gov/11934987"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Satoru Hashimoto, Sarah Boissel, Mohammed Zarhrate, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MED23 mutation links intellectual disability to dysregulation of immediate early gene expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Science (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1126/science.1206638"}], "href": "https://doi.org/10.1126/science.1206638"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21868677"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21868677"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Wei Wang, Xiao Yao, Yan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transcription (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/trns.22874"}], "href": "https://doi.org/10.4161/trns.22874"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23340209"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23340209"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Didier Monté, Bernard Clantin, Frédérique Dewitte, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Crystal structure of human Mediator subunit MED23."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-018-05967-y"}], "href": "https://doi.org/10.1038/s41467-018-05967-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30140054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30140054"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shinichi Asada, Yongmun Choi, Masaki Yamada, et al. "}, {"type": "b", "children": [{"type": "t", "text": "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2002)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.202162199"}], "href": "https://doi.org/10.1073/pnas.202162199"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12242338"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12242338"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "D C Mitchell, L J Stafford, D Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptional regulation of KiSS-1 gene expression in metastatic melanoma by specificity protein-1 and its coactivator DRIP-130."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncogene (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.onc.1209963"}], "href": "https://doi.org/10.1038/sj.onc.1209963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16964286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16964286"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Xu Yang, Meng Zhao, Min Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Selective requirement for Mediator MED23 in Ras-active lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Proc Natl Acad Sci U S A (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1073/pnas.1204311109"}], "href": "https://doi.org/10.1073/pnas.1204311109"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22988093"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22988093"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jianxin Shi, Hongcheng Liu, Feng Yao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Upregulation of mediator MED23 in non-small-cell lung cancer promotes the growth, migration, and metastasis of cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-014-2499-3"}], "href": "https://doi.org/10.1007/s13277-014-2499-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25273169"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25273169"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Yu Guo, Jing Wang, Hua Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mediator subunit 23 overexpression as a novel target for suppressing proliferation and tumorigenesis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jgh.12923"}], "href": "https://doi.org/10.1111/jgh.12923"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25684393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25684393"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Nasha Zhang, Xijun Liu, Linying Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00921 reduces lung cancer radiosensitivity by destabilizing NUDT21 and driving aberrant MED23 alternative polyadenylation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2023.113479"}], "href": "https://doi.org/10.1016/j.celrep.2023.113479"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "37999979"}], "href": "https://pubmed.ncbi.nlm.nih.gov/37999979"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yanzhe Li, Yanan Sun, Bona Jia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MED23 depletion induces premature senescence in NSCLC cells by interacting with BCLAF1 and then suppressing NUPR1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2024.150754"}], "href": "https://doi.org/10.1016/j.bbrc.2024.150754"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39366174"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39366174"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Aditi Trehan, Jacqueline M Brady, Valerie Maduro, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MED23-associated intellectual disability in a non-consanguineous family."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37047"}], "href": "https://doi.org/10.1002/ajmg.a.37047"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25845469"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25845469"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Anath C Lionel, Nasim Monfared, Stephen W Scherer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MED23-associated refractory epilepsy successfully treated with the ketogenic diet."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Med Genet A (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ajmg.a.37802"}], "href": "https://doi.org/10.1002/ajmg.a.37802"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27311965"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27311965"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Ahmed Bamaga, Osama Muthaffar, Anas Alyazidi, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "MED23"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " pathogenic variant: genomic-phenotypic analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Med Life (2024)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.25122/jml-2024-0065"}], "href": "https://doi.org/10.25122/jml-2024-0065"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "39144687"}], "href": "https://pubmed.ncbi.nlm.nih.gov/39144687"}]}]}]}
Synonyms	DRIP130, CRSP3, SUR-2, CRSP130, ARC130, SUR2, CRSP133, MRT18
Proteins	MED23_HUMAN
NCBI Gene ID	9439
API
Download Associations
Predicted Functions
Co-expressed Genes
Expression in Tissues and Cell Lines

Functional Associations

MED23 has 6,922 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, disease, phenotype or trait, functional term, phrase or reference, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 122 datasets.

Click the + buttons to view associations for MED23 from the datasets below.

If available, associations are ranked by standardized value

Harmonizome 3.0

MED23 Gene

Functional Associations

Please acknowledge the Harmonizome in your publications by citing the following reference(s):

	Dataset	Summary
	Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MED23 gene relative to other tissues from the Allen Brain Atlas Adult Human Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles	tissues with high or low expression of MED23 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset.
	Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles	tissue samples with high or low expression of MED23 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray	tissue samples with high or low expression of MED23 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset.
	Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq	tissue samples with high or low expression of MED23 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq dataset.
	Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles	tissues with high or low expression of MED23 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset.
	BioGPS Cell Line Gene Expression Profiles	cell lines with high or low expression of MED23 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset.
	BioGPS Human Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MED23 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.
	BioGPS Mouse Cell Type and Tissue Gene Expression Profiles	cell types and tissues with high or low expression of MED23 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset.
	Carcinogenome Chemical Perturbation Carcinogenicity Signatures	small molecule perturbations changing expression of MED23 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
	CCLE Cell Line Gene CNV Profiles	cell lines with high or low copy number of MED23 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
	CCLE Cell Line Gene Expression Profiles	cell lines with high or low expression of MED23 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.
	CCLE Cell Line Proteomics	Cell lines associated with MED23 protein from the CCLE Cell Line Proteomics dataset.
	ChEA Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MED23 gene from the CHEA Transcription Factor Binding Site Profiles dataset.
	ChEA Transcription Factor Targets	transcription factors binding the promoter of MED23 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.
	ChEA Transcription Factor Targets 2022	transcription factors binding the promoter of MED23 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset.
	ClinVar Gene-Phenotype Associations	phenotypes associated with MED23 gene from the curated ClinVar Gene-Phenotype Associations dataset.
	ClinVar Gene-Phenotype Associations 2025	phenotypes associated with MED23 gene from the curated ClinVar Gene-Phenotype Associations 2025 dataset.
	CM4AI KOLF21J CRISPRi Gene Perturbation Atlas	gene perturbations changing expression of MED23 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset.
	CM4AI U2OS Cell Map Protein Localization Assemblies	assemblies containing MED23 protein from integrated AP-MS and IF data from the CM4AI U2OS Cell Map Protein Localization Assemblies dataset.
	CMAP Signatures of Differentially Expressed Genes for Small Molecules	small molecule perturbations changing expression of MED23 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores	cellular components containing MED23 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.
	COMPARTMENTS Curated Protein Localization Evidence Scores 2025	cellular components containing MED23 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores	cellular components co-occuring with MED23 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.
	COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025	cellular components co-occuring with MED23 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset.
	CORUM Protein Complexes	protein complexs containing MED23 protein from the CORUM Protein Complexes dataset.
	COSMIC Cell Line Gene CNV Profiles	cell lines with high or low copy number of MED23 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
	COSMIC Cell Line Gene Mutation Profiles	cell lines with MED23 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.
	CTD Gene-Disease Associations	diseases associated with MED23 gene/protein from the curated CTD Gene-Disease Associations dataset.
	DepMap CRISPR Gene Dependency	cell lines with fitness changed by MED23 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset.
	DISEASES Curated Gene-Disease Association Evidence Scores	diseases involving MED23 gene from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores	diseases co-occuring with MED23 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.
	DISEASES Text-mining Gene-Disease Association Evidence Scores 2025	diseases co-occuring with MED23 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.
	DisGeNET Gene-Disease Associations	diseases associated with MED23 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.
	DisGeNET Gene-Phenotype Associations	phenotypes associated with MED23 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset.
	ENCODE Histone Modification Site Profiles	histone modification site profiles with high histone modification abundance at MED23 gene from the ENCODE Histone Modification Site Profiles dataset.
	ENCODE Transcription Factor Binding Site Profiles	transcription factor binding site profiles with transcription factor binding evidence at the promoter of MED23 gene from the ENCODE Transcription Factor Binding Site Profiles dataset.
	ENCODE Transcription Factor Targets	transcription factors binding the promoter of MED23 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.
	ESCAPE Omics Signatures of Genes and Proteins for Stem Cells	PubMedIDs of publications reporting gene signatures containing MED23 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.
	GDSC Cell Line Gene Expression Profiles	cell lines with high or low expression of MED23 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.