| HGNC Family | Homeoboxes |
| Name | mesenchyme homeobox 2 |
| Description | This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMEOX2 (also known as GAX) is a key homeobox transcription factor that governs vascular differentiation and endothelial cell function. It plays a central role in promoting cell cycle arrest and senescence by activating critical cyclin‐dependent kinase inhibitors (p21^CIP1/WAF1 and p16^INK4a) and thus helps maintain endothelial quiescence. Through its interactions with TGF‑β/Smad and NF‑κB signaling pathways, MEOX2 functions to regulate angiogenesis, apoptosis, and inflammatory responses. In addition, MEOX2 is modulated by various microRNAs (for example, miR‑130a and miR‑1200), and its activity impacts lipid transport in cardiac endothelial cells as well as vasculogenic potential in conditions such as diabetes and neurodegeneration."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "11"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn oncology, MEOX2 exhibits context‐dependent roles. In some tumor types—such as hepatocellular, laryngeal, Wilms, and certain breast carcinomas—reduced MEOX2 expression is associated with higher histological grade, increased proliferative markers, and poorer patient outcomes, supporting its tumor‐suppressive function via induction of cell cycle arrest and apoptosis. Conversely, in gliomas, glioblastomas, and subsets of lung cancers, elevated MEOX2 levels correlate with aggressive behavior, enhanced epithelial–mesenchymal transition, chemoresistance, and invasive potential, partly through the regulation of pathways such as PI3K/AKT/mTOR and ERK1/2 and by transactivating targets like cathepsin S."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "12", "end_ref": "21"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nBeyond its roles in vascular homeostasis and tumor biology, MEOX2 is also implicated in developmental processes and tissue regeneration. Genetic polymorphisms in MEOX2 have been linked to congenital craniofacial anomalies such as nonsyndromic cleft palate, and experimental knockdown studies in bone and periodontal models suggest that reducing MEOX2 activity can enhance osteogenic differentiation and improve bone healing."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhenhua Wu, Huang Guo, Nienwen Chow, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Med (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/nm1287"}], "href": "https://doi.org/10.1038/nm1287"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16116430"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16116430"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jijin Lin, Mona T Friesen, Patricia Bocangel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cell Biochem (2005)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11010-005-0823-3"}], "href": "https://doi.org/10.1007/s11010-005-0823-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "16335786"}], "href": "https://pubmed.ncbi.nlm.nih.gov/16335786"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yun Chen, Alejandro D Leal, Sejal Patel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M606604200"}], "href": "https://doi.org/10.1074/jbc.M606604200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17074759"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17074759"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yun Chen, David H Gorski "}, {"type": "b", "children": [{"type": "t", "text": "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Blood (2008)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1182/blood-2007-07-104133"}], "href": "https://doi.org/10.1182/blood-2007-07-104133"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17957028"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17957028"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Jeffrey T Irelan, Ana Gutierrez Del Arroyo, Abel Gutierrez, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A functional screen for regulators of CKDN2A reveals MEOX2 as a transcriptional activator of INK4a."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0005067"}], "href": "https://doi.org/10.1371/journal.pone.0005067"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19340300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19340300"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Ulrich Valcourt, Sylvie Thuault, Katerina Pardali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional role of Meox2 during the epithelial cytostatic response to TGF-beta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molonc.2007.02.002"}], "href": "https://doi.org/10.1016/j.molonc.2007.02.002"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19383287"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19383287"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Yun Chen, Arnold B Rabson, David H Gorski "}, {"type": "b", "children": [{"type": "t", "text": "MEOX2 regulates nuclear factor-kappaB activity in vascular endothelial cells through interactions with p65 and IkappaBbeta."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cardiovasc Res (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/cvr/cvq117"}], "href": "https://doi.org/10.1093/cvr/cvq117"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20421348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20421348"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Josette M Douville, David Y C Cheung, Krista L Herbert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0029099"}], "href": "https://doi.org/10.1371/journal.pone.0029099"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22206000"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22206000"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Wen-Yi Yang, Thibault Petit, Lutgarde Thijs, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genet (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12863-015-0272-2"}], "href": "https://doi.org/10.1186/s12863-015-0272-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26428460"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26428460"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Cassandra R Gohn, Emily K Blue, BreAnn M Sheehan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchyme Homeobox 2 Enhances Migration of Endothelial Colony Forming Cells Exposed to Intrauterine Diabetes Mellitus."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.25734"}], "href": "https://doi.org/10.1002/jcp.25734"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27966787"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27966787"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Yan Huang, Bo Liang, Xiangjuan Chen "}, {"type": "b", "children": [{"type": "t", "text": "Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1967077"}], "href": "https://doi.org/10.1080/21655979.2021.1967077"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34516311"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34516311"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Junjiro Ohshima, Masayuki Haruta, Yasuhito Arai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20705"}], "href": "https://doi.org/10.1002/gcc.20705"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19760604"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19760604"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Peng Zhou, Zhi Chen, Rui-Min Chang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Growth arrest-specific homeobox is associated with poor survival in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Med Oncol (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12032-012-0258-0"}], "href": "https://doi.org/10.1007/s12032-012-0258-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22644917"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22644917"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Federico Ávila-Moreno, Leonel Armas-López, Aldo M Álvarez-Moran, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of MEOX2 and TWIST1 is associated with H3K27me3 levels and determines lung cancer chemoresistance and prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0114104"}], "href": "https://doi.org/10.1371/journal.pone.0114104"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25460568"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25460568"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "L Tian, Z Z Tao, H P Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Over-expression of MEOX2 promotes apoptosis through inhibiting the PI3K/Akt pathway in laryngeal cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neoplasma (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4149/neo_2018_171218N824"}], "href": "https://doi.org/10.4149/neo_2018_171218N824"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29940775"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29940775"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Gaelle Tachon, Konstantin Masliantsev, Pierre Rivet, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prognostic significance of MEOX2 in gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mod Pathol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41379-018-0192-6"}], "href": "https://doi.org/10.1038/s41379-018-0192-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30659268"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30659268"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Wulong Wang, Guodai Hong, Siyuan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX)."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1886771"}], "href": "https://doi.org/10.1080/21655979.2021.1886771"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33627047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33627047"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Yun Cai, Yi Liu, Ye Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mesenchyme homeobox 2 has a cancer-inhibiting function in breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2022.01.011"}], "href": "https://doi.org/10.1016/j.bbrc.2022.01.011"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35051778"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35051778"}]}, {"type": "r", "ref": 19, "children": [{"type": "t", "text": "Ji Wang, Yanming Chen, Qing Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-022-04845-2"}], "href": "https://doi.org/10.1038/s41419-022-04845-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35436995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35436995"}]}, {"type": "r", "ref": 20, "children": [{"type": "t", "text": "Anna Schönrock, Elisa Heinzelmann, Bianca Steffl, et al. "}, {"type": "b", "children": [{"type": "t", "text": "MEOX2 homeobox gene promotes growth of malignant gliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuro Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/neuonc/noac110"}], "href": "https://doi.org/10.1093/neuonc/noac110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35468210"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35468210"}]}, {"type": "r", "ref": 21, "children": [{"type": "t", "text": "Huxia Wang, Yanan Tang, Meixia Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Low expression of MEOX2 is associated with poor survival in patients with breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomark Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2217/bmm-2022-0468"}], "href": "https://doi.org/10.2217/bmm-2022-0468"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36625258"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36625258"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Duy L Tran, Hideto Imura, Akihiro Mori, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Association of MEOX2 polymorphism with nonsyndromic cleft palate only in a Vietnamese population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Congenit Anom (Kyoto) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cga.12259"}], "href": "https://doi.org/10.1111/cga.12259"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29030958"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29030958"}]}, {"type": "r", "ref": 23, "children": [{"type": "t", "text": "Tae-Young Kim, Jae-Kyung Park, Yam Prasad Aryal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Facilitation of Bone Healing Processes Based on the Developmental Function of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Meox2"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " in Tooth Loss Lesion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21228701"}], "href": "https://doi.org/10.3390/ijms21228701"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33218046"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33218046"}]}]}]}
|
| Synonyms | GAX, MOX2 |
| Proteins | MEOX2_HUMAN |
| NCBI Gene ID | 4223 |
| API | |
| Download Associations | |
| Predicted Functions |
 |
| Co-expressed Genes |
|
| Expression in Tissues and Cell Lines |
|
MEOX2 has 5,876 functional associations with biological entities spanning 9 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA, sequence feature) extracted from 107 datasets.
Click the + buttons to view associations for MEOX2 from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of MEOX2 gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles | tissues with high or low expression of MEOX2 gene relative to other tissues from the Allen Brain Atlas Prenatal Human Brain Tissue Gene Expression Profiles dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of MEOX2 gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MEOX2 gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MEOX2 gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of MEOX2 gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MEOX2 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MEOX2 gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| CellMarker Gene-Cell Type Associations | cell types associated with MEOX2 gene from the CellMarker Gene-Cell Type Associations dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MEOX2 gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MEOX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MEOX2 gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of MEOX2 gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MEOX2 gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing MEOX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing MEOX2 protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with MEOX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MEOX2 protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MEOX2 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with MEOX2 gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with MEOX2 gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| dbGAP Gene-Trait Associations | traits associated with MEOX2 gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by MEOX2 gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores | diseases associated with MEOX2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Experimental Gene-Disease Association Evidence Scores 2025 | diseases associated with MEOX2 gene in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with MEOX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MEOX2 gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with MEOX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| DisGeNET Gene-Phenotype Associations | phenotypes associated with MEOX2 gene in GWAS and other genetic association datasets from the DisGeNET Gene-Phenoptype Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MEOX2 gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MEOX2 gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MEOX2 gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MEOX2 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with MEOX2 gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with MEOX2 gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of MEOX2 gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MEOX2 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MEOX2 from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MEOX2 gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MEOX2 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MEOX2 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MEOX2 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MEOX2 gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MEOX2 gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving MEOX2 gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Biological Process Annotations 2023 | biological processes involving MEOX2 gene from the curated GO Biological Process Annotations 2023 dataset. | |
| GO Biological Process Annotations 2025 | biological processes involving MEOX2 gene from the curated GO Biological Process Annotations2025 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing MEOX2 protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2023 | cellular components containing MEOX2 protein from the curated GO Cellular Component Annotations 2023 dataset. | |
| GO Cellular Component Annotations 2025 | cellular components containing MEOX2 protein from the curated GO Cellular Component Annotations 2025 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by MEOX2 gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by MEOX2 gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by MEOX2 gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx eQTL 2025 | SNPs regulating expression of MEOX2 gene from the GTEx eQTL 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MEOX2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MEOX2 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GTEx Tissue-Specific Aging Signatures | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the GTEx Tissue-Specific Aging Signatures dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with MEOX2 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MEOX2 gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MEOX2 gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of MEOX2 gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of MEOX2 gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of MEOX2 protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| HuBMAP Azimuth Cell Type Annotations | cell types associated with MEOX2 gene from the HuBMAP Azimuth Cell Type Annotations dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with MEOX2 gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for MEOX2 protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of MEOX2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of MEOX2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MEOX2 gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| Kinase Library Serine Threonine Kinome Atlas | kinases that phosphorylate MEOX2 protein from the Kinase Library Serine Threonine Atlas dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MEOX2 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MEOX2 gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of MEOX2 gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of MEOX2 gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MEOX2 gene from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing MEOX2 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MEOX2 protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MEOX2 gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting MEOX2 gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MEOX2 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MoTrPAC Rat Endurance Exercise Training | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the MoTrPAC Rat Endurance Exercise Training dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by MEOX2 gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Cancer Gene Co-expression Modules | co-expressed genes for MEOX2 from the MSigDB Cancer Gene Co-expression Modules dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MEOX2 gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for MEOX2 from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MEOX2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of MEOX2 gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PFOCR Pathway Figure Associations 2023 | pathways involving MEOX2 protein from the PFOCR Pathway Figure Associations 2023 dataset. | |
| PFOCR Pathway Figure Associations 2024 | pathways involving MEOX2 protein from the Wikipathways PFOCR 2024 dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MEOX2 gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of MEOX2 gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MEOX2 gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MEOX2 gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tahoe Therapeutics Tahoe 100M Perturbation Atlas | drug perturbations changing expression of MEOX2 gene from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset. | |
| TargetScan Predicted Conserved microRNA Targets | microRNAs regulating expression of MEOX2 gene predicted using conserved miRNA seed sequences from the TargetScan Predicted Conserved microRNA Targets dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MEOX2 gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MEOX2 gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of MEOX2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MEOX2 protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of MEOX2 protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with MEOX2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MEOX2 protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
| WikiPathways Pathways 2014 | pathways involving MEOX2 protein from the Wikipathways Pathways 2014 dataset. | |
