| HGNC Family | Metzincin metallopeptidases |
| Name | meprin A, beta |
| Description | Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011] |
| Summary |
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nMeprin β (MEP1B) is a zinc‐dependent metalloprotease that plays a central role in extracellular protein processing. It cleaves a broad spectrum of substrates including the amyloid precursor protein (APP)—thereby generating alternative, potentially aggregation‐prone Aβ peptides—and extracellular matrix proteins such as procollagens and tenascin‑C, where its proteolytic activity contributes to proper collagen fibril formation and modulation of cell–matrix interactions. In addition, meprin β activates key enzymes such as ADAM10 via removal of inhibitory propeptides, collectively influencing tissue remodeling and cell signaling in both physiological and pathological contexts."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n \nMeprin β activity is tightly regulated at multiple levels. Posttranslational modifications, such as O‑glycosylation (which clusters near its major processing site), and controlled ectodomain shedding—mediated by proteases like ADAM17—determine its cell surface retention versus secretion. It is also subject to proteolytic activation by enzymes including furin‐like proteases and TMPRSS6, while interactions with tetraspanin family members (for example, TSPAN8) help organize it within specialized membrane microdomains. Functional cleavage of substrates extends to regulators of ion transport (cleavage of ENaC subunits) and inflammatory mediators, as exemplified by its capacity to process interleukin‑6, thereby dampening cytokine activity. In some cases, naturally occurring variants further modulate its activation, phosphorylation, and shedding dynamics, influencing its overall catalytic output."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "14"}]}, {"type": "t", "text": "\n \nIn pathological states, aberrant expression and activity of meprin β have been implicated in diverse disorders. Its expression in the epidermis, lung epithelium, and vascular smooth muscle cells underlies roles in tissue differentiation, fibrosis, and vascular remodeling—as seen in conditions ranging from inflammatory bowel and pulmonary diseases to hypertension. Moreover, meprin β is being explored as a drug target in fibrotic syndromes and kidney injury, with structural studies guiding the design of selective inhibitors and cleavable linkers that exploit its substrate specificity. Elevated activity has also been connected to tumor biology, including in gastric cancer, highlighting its multifaceted involvement in both normal homeostasis and disease."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "15", "end_ref": "22"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Daniel Ambort, Florence Brellier, Christoph Becker-Pauly, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Specific processing of tenascin-C by the metalloprotease meprinbeta neutralizes its inhibition of cell spreading."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Matrix Biol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.matbio.2009.08.007"}], "href": "https://doi.org/10.1016/j.matbio.2009.08.007"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19748582"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19748582"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniel Kronenberg, Bernd C Bruns, Catherine Moali, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Processing of procollagen III by meprins: new players in extracellular matrix assembly?"}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jid.2010.202"}], "href": "https://doi.org/10.1038/jid.2010.202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20631730"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20631730"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Tamara Jefferson, Mirsada Čaušević, Ulrich auf dem Keller, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M111.252718"}], "href": "https://doi.org/10.1074/jbc.M111.252718"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "21646356"}], "href": "https://pubmed.ncbi.nlm.nih.gov/21646356"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Jessica Bien, Tamara Jefferson, Mirsada Causević, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The metalloprotease meprin β generates amino terminal-truncated amyloid β peptide species."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2012)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M112.395608"}], "href": "https://doi.org/10.1074/jbc.M112.395608"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22879596"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22879596"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Tamara Jefferson, Ulrich Auf dem Keller, Caroline Bellac, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Life Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s00018-012-1106-2"}], "href": "https://doi.org/10.1007/s00018-012-1106-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "22940918"}], "href": "https://pubmed.ncbi.nlm.nih.gov/22940918"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Boris Leuenberger, Dagmar Hahn, Anastassios Pischitzis, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Human meprin beta: O-linked glycans in the intervening region of the type I membrane protein protect the C-terminal region from proteolytic cleavage and diminish its secretion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20021398"}], "href": "https://doi.org/10.1042/BJ20021398"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12387727"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12387727"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Dagmar Hahn, Anastassios Pischitzis, Sandra Roesmann, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phorbol 12-myristate 13-acetate-induced ectodomain shedding and phosphorylation of the human meprinbeta metalloprotease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2003)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.M211169200"}], "href": "https://doi.org/10.1074/jbc.M211169200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "12941954"}], "href": "https://pubmed.ncbi.nlm.nih.gov/12941954"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Agustin Garcia-Caballero, Susan S Ishmael, Yan Dang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Activation of the epithelial sodium channel by the metalloprotease meprin β subunit."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Channels (Austin) (2011)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/chan.5.1.13759"}], "href": "https://doi.org/10.4161/chan.5.1.13759"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20953144"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20953144"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Ying-Jie Li, Ya-Han Fan, Jian Tang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meprin-β regulates production of pro-inflammatory factors via a disintegrin and metalloproteinase-10 (ADAM-10) dependent pathway in macrophages."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2013.11.004"}], "href": "https://doi.org/10.1016/j.intimp.2013.11.004"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24239627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24239627"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Felix Jäckle, Frederike Schmidt, Rielana Wichert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem J (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1042/BJ20141417"}], "href": "https://doi.org/10.1042/BJ20141417"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26251449"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26251449"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Frederike Schmidt, Miryam Müller, Johannes Prox, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Chem (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/hsz-2016-0126"}], "href": "https://doi.org/10.1515/hsz-2016-0126"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27180358"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27180358"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Rielana Wichert, Anna Ermund, Stefanie Schmidt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Mucus Detachment by Host Metalloprotease Meprin β Requires Shedding of Its Inactive Pro-form, which Is Abrogated by the Pathogenic Protease RgpB."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.celrep.2017.10.087"}], "href": "https://doi.org/10.1016/j.celrep.2017.10.087"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29166602"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29166602"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Henning Schäffler, Wenjia Li, Ole Helm, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The cancer-associated meprin β variant G32R provides an additional activation site and promotes cancer cell invasion."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Sci (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1242/jcs.220665"}], "href": "https://doi.org/10.1242/jcs.220665"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31076514"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31076514"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Preeti Kumaran Menon, Niina Anneli Koistinen, Kerstin Iverfeldt, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biol Chem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1074/jbc.RA119.008310"}], "href": "https://doi.org/10.1074/jbc.RA119.008310"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31604820"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31604820"}]}, {"type": "r", "ref": 15, "children": [{"type": "t", "text": "Christoph Becker-Pauly, Markus Höwel, Tatjana Walker, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The alpha and beta subunits of the metalloprotease meprin are expressed in separate layers of human epidermis, revealing different functions in keratinocyte proliferation and differentiation."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Invest Dermatol (2007)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/sj.jid.5700675"}], "href": "https://doi.org/10.1038/sj.jid.5700675"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "17195012"}], "href": "https://pubmed.ncbi.nlm.nih.gov/17195012"}]}, {"type": "r", "ref": 16, "children": [{"type": "t", "text": "Jana Hedrich, Daniel Lottaz, Katharina Meyer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Fetuin-A and cystatin C are endogenous inhibitors of human meprin metalloproteases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1021/bi1004238"}], "href": "https://doi.org/10.1021/bi1004238"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20806899"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20806899"}]}, {"type": "r", "ref": 17, "children": [{"type": "t", "text": "Valentina Biasin, Leigh M Marsh, Bakytbek Egemnazarov, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meprin β, a novel mediator of vascular remodelling underlying pulmonary hypertension."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pathol (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/path.4303"}], "href": "https://doi.org/10.1002/path.4303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24258247"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24258247"}]}, {"type": "r", "ref": 18, "children": [{"type": "t", "text": "Andreas Jodal, Fabienne Pape, Christoph Becker-Pauly, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms22115651"}], "href": "https://doi.org/10.3390/ijms22115651"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34073350"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34073350"}]}, {"type": "r", "ref": 22, "children": [{"type": "t", "text": "Wiebke Siemsen, Christine Halske, Hans-Michael Behrens, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The putative pleiotropic functions of meprin β in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gastric Cancer (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10120-023-01385-2"}], "href": "https://doi.org/10.1007/s10120-023-01385-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "36976399"}], "href": "https://pubmed.ncbi.nlm.nih.gov/36976399"}]}]}]}
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| Proteins | MEP1B_HUMAN |
| NCBI Gene ID | 4225 |
| API | |
| Download Associations | |
| Predicted Functions |
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| Co-expressed Genes |
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| Expression in Tissues and Cell Lines |
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MEP1B has 3,482 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 96 datasets.
Click the + buttons to view associations for MEP1B from the datasets below.
If available, associations are ranked by standardized value
| Dataset | Summary | |
|---|---|---|
| Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles | tissues with high or low expression of MEP1B gene relative to other tissues from the Allen Brain Atlas Adult Mouse Brain Tissue Gene Expression Profiles dataset. | |
| Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MEP1B gene relative to other tissue samples from the Allen Brain Atlas Aging Dementia and Traumatic Brain Injury Tissue Sample Gene Expression Profiles dataset. | |
| Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray | tissue samples with high or low expression of MEP1B gene relative to other tissue samples from the Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by Microarray dataset. | |
| BioGPS Cell Line Gene Expression Profiles | cell lines with high or low expression of MEP1B gene relative to other cell lines from the BioGPS Cell Line Gene Expression Profiles dataset. | |
| BioGPS Human Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MEP1B gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset. | |
| BioGPS Mouse Cell Type and Tissue Gene Expression Profiles | cell types and tissues with high or low expression of MEP1B gene relative to other cell types and tissues from the BioGPS Mouse Cell Type and Tissue Gene Expression Profiles dataset. | |
| Carcinogenome Chemical Perturbation Carcinogenicity Signatures | small molecule perturbations changing expression of MEP1B gene from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset. | |
| CCLE Cell Line Gene CNV Profiles | cell lines with high or low copy number of MEP1B gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset. | |
| CCLE Cell Line Gene Expression Profiles | cell lines with high or low expression of MEP1B gene relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset. | |
| ChEA Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MEP1B gene from the CHEA Transcription Factor Binding Site Profiles dataset. | |
| ChEA Transcription Factor Targets | transcription factors binding the promoter of MEP1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset. | |
| ChEA Transcription Factor Targets 2022 | transcription factors binding the promoter of MEP1B gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets 2022 dataset. | |
| CM4AI KOLF21J CRISPRi Gene Perturbation Atlas | gene perturbations changing expression of MEP1B gene from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas dataset. | |
| CMAP Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MEP1B gene from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores | cellular components containing MEP1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Curated Protein Localization Evidence Scores 2025 | cellular components containing MEP1B protein from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores | cellular components co-occuring with MEP1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset. | |
| COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 | cellular components co-occuring with MEP1B protein in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores 2025 dataset. | |
| CORUM Protein Complexes | protein complexs containing MEP1B protein from the CORUM Protein Complexes dataset. | |
| COSMIC Cell Line Gene CNV Profiles | cell lines with high or low copy number of MEP1B gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset. | |
| COSMIC Cell Line Gene Mutation Profiles | cell lines with MEP1B gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset. | |
| CTD Gene-Disease Associations | diseases associated with MEP1B gene/protein from the curated CTD Gene-Disease Associations dataset. | |
| DepMap CRISPR Gene Dependency | cell lines with fitness changed by MEP1B gene knockdown relative to other cell lines from the DepMap CRISPR Gene Dependency dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores | diseases co-occuring with MEP1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset. | |
| DISEASES Text-mining Gene-Disease Association Evidence Scores 2025 | diseases co-occuring with MEP1B gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset. | |
| DisGeNET Gene-Disease Associations | diseases associated with MEP1B gene in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset. | |
| ENCODE Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MEP1B gene from the ENCODE Histone Modification Site Profiles dataset. | |
| ENCODE Transcription Factor Binding Site Profiles | transcription factor binding site profiles with transcription factor binding evidence at the promoter of MEP1B gene from the ENCODE Transcription Factor Binding Site Profiles dataset. | |
| ENCODE Transcription Factor Targets | transcription factors binding the promoter of MEP1B gene in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset. | |
| ESCAPE Omics Signatures of Genes and Proteins for Stem Cells | PubMedIDs of publications reporting gene signatures containing MEP1B from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. | |
| GAD Gene-Disease Associations | diseases associated with MEP1B gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset. | |
| GAD High Level Gene-Disease Associations | diseases associated with MEP1B gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset. | |
| GDSC Cell Line Gene Expression Profiles | cell lines with high or low expression of MEP1B gene relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset. | |
| GeneRIF Biological Term Annotations | biological terms co-occuring with MEP1B gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset. | |
| GeneSigDB Published Gene Signatures | PubMedIDs of publications reporting gene signatures containing MEP1B from the GeneSigDB Published Gene Signatures dataset. | |
| GEO Signatures of Differentially Expressed Genes for Diseases | disease perturbations changing expression of MEP1B gene from the GEO Signatures of Differentially Expressed Genes for Diseases dataset. | |
| GEO Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MEP1B gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Kinase Perturbations | kinase perturbations changing expression of MEP1B gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Small Molecules | small molecule perturbations changing expression of MEP1B gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset. | |
| GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations | transcription factor perturbations changing expression of MEP1B gene from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset. | |
| GEO Signatures of Differentially Expressed Genes for Viral Infections | virus perturbations changing expression of MEP1B gene from the GEO Signatures of Differentially Expressed Genes for Viral Infections dataset. | |
| GO Biological Process Annotations 2015 | biological processes involving MEP1B gene from the curated GO Biological Process Annotations 2015 dataset. | |
| GO Cellular Component Annotations 2015 | cellular components containing MEP1B protein from the curated GO Cellular Component Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2015 | molecular functions performed by MEP1B gene from the curated GO Molecular Function Annotations 2015 dataset. | |
| GO Molecular Function Annotations 2023 | molecular functions performed by MEP1B gene from the curated GO Molecular Function Annotations 2023 dataset. | |
| GO Molecular Function Annotations 2025 | molecular functions performed by MEP1B gene from the curated GO Molecular Function Annotations 2025 dataset. | |
| GTEx Tissue Gene Expression Profiles | tissues with high or low expression of MEP1B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset. | |
| GTEx Tissue Gene Expression Profiles 2023 | tissues with high or low expression of MEP1B gene relative to other tissues from the GTEx Tissue Gene Expression Profiles 2023 dataset. | |
| GTEx Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MEP1B gene relative to other tissue samples from the GTEx Tissue Sample Gene Expression Profiles dataset. | |
| GWAS Catalog SNP-Phenotype Associations 2025 | phenotypes associated with MEP1B gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations 2025 dataset. | |
| GWASdb SNP-Disease Associations | diseases associated with MEP1B gene in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset. | |
| GWASdb SNP-Phenotype Associations | phenotypes associated with MEP1B gene in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset. | |
| Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles | cell lines with high or low expression of MEP1B gene relative to other cell lines from the Heiser et al., PNAS, 2011 Cell Line Gene Expression Profiles dataset. | |
| HPA Cell Line Gene Expression Profiles | cell lines with high or low expression of MEP1B gene relative to other cell lines from the HPA Cell Line Gene Expression Profiles dataset. | |
| HPA Tissue Gene Expression Profiles | tissues with high or low expression of MEP1B gene relative to other tissues from the HPA Tissue Gene Expression Profiles dataset. | |
| HPA Tissue Protein Expression Profiles | tissues with high or low expression of MEP1B protein relative to other tissues from the HPA Tissue Protein Expression Profiles dataset. | |
| HPA Tissue Sample Gene Expression Profiles | tissue samples with high or low expression of MEP1B gene relative to other tissue samples from the HPA Tissue Sample Gene Expression Profiles dataset. | |
| Hub Proteins Protein-Protein Interactions | interacting hub proteins for MEP1B from the curated Hub Proteins Protein-Protein Interactions dataset. | |
| HuGE Navigator Gene-Phenotype Associations | phenotypes associated with MEP1B gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset. | |
| IMPC Knockout Mouse Phenotypes | phenotypes of mice caused by MEP1B gene knockout from the IMPC Knockout Mouse Phenotypes dataset. | |
| InterPro Predicted Protein Domain Annotations | protein domains predicted for MEP1B protein from the InterPro Predicted Protein Domain Annotations dataset. | |
| JASPAR Predicted Human Transcription Factor Targets 2025 | transcription factors regulating expression of MEP1B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Human Transcription Factor Targets dataset. | |
| JASPAR Predicted Mouse Transcription Factor Targets 2025 | transcription factors regulating expression of MEP1B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Mouse Transcription Factor Targets 2025 dataset. | |
| JASPAR Predicted Transcription Factor Targets | transcription factors regulating expression of MEP1B gene predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset. | |
| KEA Substrates of Kinases | kinases that phosphorylate MEP1B protein from the curated KEA Substrates of Kinases dataset. | |
| KEGG Pathways 2026 | pathways involving MEP1B protein from the KEGG Pathways 2026 dataset. | |
| Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles | cell lines with high or low copy number of MEP1B gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset. | |
| KnockTF Gene Expression Profiles with Transcription Factor Perturbations | transcription factor perturbations changing expression of MEP1B gene from the KnockTF Gene Expression Profiles with Transcription Factor Perturbations dataset. | |
| LINCS L1000 CMAP Chemical Perturbation Consensus Signatures | small molecule perturbations changing expression of MEP1B gene from the LINCS L1000 CMAP Chemical Perturbations Consensus Signatures dataset. | |
| LINCS L1000 CMAP CRISPR Knockout Consensus Signatures | gene perturbations changing expression of MEP1B gene from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset. | |
| LOCATE Curated Protein Localization Annotations | cellular components containing MEP1B protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset. | |
| LOCATE Predicted Protein Localization Annotations | cellular components predicted to contain MEP1B protein from the LOCATE Predicted Protein Localization Annotations dataset. | |
| MGI Mouse Phenotype Associations 2023 | phenotypes of transgenic mice caused by MEP1B gene mutations from the MGI Mouse Phenotype Associations 2023 dataset. | |
| MiRTarBase microRNA Targets | microRNAs targeting MEP1B gene in low- or high-throughput microRNA targeting studies from the MiRTarBase microRNA Targets dataset. | |
| MotifMap Predicted Transcription Factor Targets | transcription factors regulating expression of MEP1B gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset. | |
| MPO Gene-Phenotype Associations | phenotypes of transgenic mice caused by MEP1B gene mutations from the MPO Gene-Phenotype Associations dataset. | |
| MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations | gene perturbations changing expression of MEP1B gene from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset. | |
| NURSA Protein Complexes | protein complexs containing MEP1B protein recovered by IP-MS from the NURSA Protein Complexes dataset. | |
| Pathway Commons Protein-Protein Interactions | interacting proteins for MEP1B from the Pathway Commons Protein-Protein Interactions dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations | gene perturbations changing expression of MEP1B gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| PerturbAtlas Signatures of Differentially Expressed Genes for Mouse Gene Perturbations | gene perturbations changing expression of MEP1B gene from the PerturbAtlas Signatures of Differentially Expressed Genes for Gene Perturbations dataset. | |
| Phosphosite Textmining Biological Term Annotations | biological terms co-occuring with MEP1B protein in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset. | |
| PID Pathways | pathways involving MEP1B protein from the PID Pathways dataset. | |
| Roadmap Epigenomics Histone Modification Site Profiles | histone modification site profiles with high histone modification abundance at MEP1B gene from the Roadmap Epigenomics Histone Modification Site Profiles dataset. | |
| Rummagene Transcription Factor Associations 2026 | transcription factors regulating expression of MEP1B gene from the Rummagene Transcription Factor Associations 2026 dataset. | |
| RummaGEO Drug Perturbation Signatures | drug perturbations changing expression of MEP1B gene from the RummaGEO Drug Perturbation Signatures dataset. | |
| RummaGEO Gene Perturbation Signatures | gene perturbations changing expression of MEP1B gene from the RummaGEO Gene Perturbation Signatures dataset. | |
| Tabula Sapiens Gene-Cell Associations | cell types with high or low expression of MEP1B gene relative to other cell types from the Tabula Sapiens Gene-Cell Associations dataset. | |
| TargetScan Predicted Nonconserved microRNA Targets | microRNAs regulating expression of MEP1B gene predicted using nonconserved miRNA seed sequences from the TargetScan Predicted Nonconserved microRNA Targets dataset. | |
| TCGA Signatures of Differentially Expressed Genes for Tumors | tissue samples with high or low expression of MEP1B gene relative to other tissue samples from the TCGA Signatures of Differentially Expressed Genes for Tumors dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores | tissues with high expression of MEP1B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Curated Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MEP1B protein from the TISSUES Curated Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores | tissues with high expression of MEP1B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 | tissues with high expression of MEP1B protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores 2025 dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores | tissues co-occuring with MEP1B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset. | |
| TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 | tissues co-occuring with MEP1B protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores 2025 dataset. | |
